ID   GUTR_BACSU              Reviewed;         829 AA.
AC   P39143;
DT   01-FEB-1995, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1995, sequence version 1.
DT   03-AUG-2022, entry version 141.
DE   RecName: Full=Transcription activator GutR;
GN   Name=gutR; OrderedLocusNames=BSU06140;
OS   Bacillus subtilis (strain 168).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Bacillus.
OX   NCBI_TaxID=224308;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=168;
RX   PubMed=8195087; DOI=10.1128/jb.176.11.3321-3327.1994;
RA   Ye R., Rehemtulla S.N., Wong S.-L.;
RT   "Glucitol induction in Bacillus subtilis is mediated by a regulatory
RT   factor, GutR.";
RL   J. Bacteriol. 176:3321-3327(1994).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=168 / Marburg / ATCC 6051 / DSM 10 / JCM 1465 / NBRC 13719 / NCIMB
RC   3610 / NRRL NRS-744 / VKM B-501;
RX   PubMed=9455482; DOI=10.1093/dnares/4.5.335;
RA   Kasahara Y., Nakai S., Ogasawara N., Yata K., Sadaie Y.;
RT   "Sequence analysis of the groESL-cotA region of the Bacillus subtilis
RT   genome, containing the restriction/modification system genes.";
RL   DNA Res. 4:335-339(1997).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=168;
RX   PubMed=9384377; DOI=10.1038/36786;
RA   Kunst F., Ogasawara N., Moszer I., Albertini A.M., Alloni G., Azevedo V.,
RA   Bertero M.G., Bessieres P., Bolotin A., Borchert S., Borriss R.,
RA   Boursier L., Brans A., Braun M., Brignell S.C., Bron S., Brouillet S.,
RA   Bruschi C.V., Caldwell B., Capuano V., Carter N.M., Choi S.-K.,
RA   Codani J.-J., Connerton I.F., Cummings N.J., Daniel R.A., Denizot F.,
RA   Devine K.M., Duesterhoeft A., Ehrlich S.D., Emmerson P.T., Entian K.-D.,
RA   Errington J., Fabret C., Ferrari E., Foulger D., Fritz C., Fujita M.,
RA   Fujita Y., Fuma S., Galizzi A., Galleron N., Ghim S.-Y., Glaser P.,
RA   Goffeau A., Golightly E.J., Grandi G., Guiseppi G., Guy B.J., Haga K.,
RA   Haiech J., Harwood C.R., Henaut A., Hilbert H., Holsappel S., Hosono S.,
RA   Hullo M.-F., Itaya M., Jones L.-M., Joris B., Karamata D., Kasahara Y.,
RA   Klaerr-Blanchard M., Klein C., Kobayashi Y., Koetter P., Koningstein G.,
RA   Krogh S., Kumano M., Kurita K., Lapidus A., Lardinois S., Lauber J.,
RA   Lazarevic V., Lee S.-M., Levine A., Liu H., Masuda S., Mauel C.,
RA   Medigue C., Medina N., Mellado R.P., Mizuno M., Moestl D., Nakai S.,
RA   Noback M., Noone D., O'Reilly M., Ogawa K., Ogiwara A., Oudega B.,
RA   Park S.-H., Parro V., Pohl T.M., Portetelle D., Porwollik S.,
RA   Prescott A.M., Presecan E., Pujic P., Purnelle B., Rapoport G., Rey M.,
RA   Reynolds S., Rieger M., Rivolta C., Rocha E., Roche B., Rose M., Sadaie Y.,
RA   Sato T., Scanlan E., Schleich S., Schroeter R., Scoffone F., Sekiguchi J.,
RA   Sekowska A., Seror S.J., Serror P., Shin B.-S., Soldo B., Sorokin A.,
RA   Tacconi E., Takagi T., Takahashi H., Takemaru K., Takeuchi M.,
RA   Tamakoshi A., Tanaka T., Terpstra P., Tognoni A., Tosato V., Uchiyama S.,
RA   Vandenbol M., Vannier F., Vassarotti A., Viari A., Wambutt R., Wedler E.,
RA   Wedler H., Weitzenegger T., Winters P., Wipat A., Yamamoto H., Yamane K.,
RA   Yasumoto K., Yata K., Yoshida K., Yoshikawa H.-F., Zumstein E.,
RA   Yoshikawa H., Danchin A.;
RT   "The complete genome sequence of the Gram-positive bacterium Bacillus
RT   subtilis.";
RL   Nature 390:249-256(1997).
CC   -!- FUNCTION: Activator of the glucitol dehydrogenase gene (gutB).
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DR   EMBL; L19113; AAA20676.1; -; Genomic_DNA.
DR   EMBL; AB007637; BAA22758.1; -; Genomic_DNA.
DR   EMBL; AL009126; CAB12433.1; -; Genomic_DNA.
DR   PIR; I40014; I40014.
DR   RefSeq; NP_388495.1; NC_000964.3.
DR   RefSeq; WP_003234045.1; NZ_JNCM01000032.1.
DR   AlphaFoldDB; P39143; -.
DR   SMR; P39143; -.
DR   STRING; 224308.BSU06140; -.
DR   PaxDb; P39143; -.
DR   PRIDE; P39143; -.
DR   EnsemblBacteria; CAB12433; CAB12433; BSU_06140.
DR   GeneID; 938026; -.
DR   KEGG; bsu:BSU06140; -.
DR   PATRIC; fig|224308.179.peg.665; -.
DR   eggNOG; COG0457; Bacteria.
DR   InParanoid; P39143; -.
DR   OMA; KSWIGQM; -.
DR   BioCyc; BSUB:BSU06140-MON; -.
DR   Proteomes; UP000001570; Chromosome.
DR   GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR   GO; GO:0043531; F:ADP binding; IEA:InterPro.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0051607; P:defense response to virus; IBA:GO_Central.
DR   Gene3D; 1.25.40.10; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR002182; NB-ARC.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR011990; TPR-like_helical_dom_sf.
DR   InterPro; IPR019734; TPR_repeat.
DR   Pfam; PF00931; NB-ARC; 1.
DR   Pfam; PF13176; TPR_7; 1.
DR   SMART; SM00382; AAA; 1.
DR   SMART; SM00028; TPR; 3.
DR   SUPFAM; SSF48452; SSF48452; 2.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   PROSITE; PS50005; TPR; 3.
DR   PROSITE; PS50293; TPR_REGION; 1.
PE   4: Predicted;
KW   Activator; ATP-binding; DNA-binding; Nucleotide-binding;
KW   Reference proteome; Repeat; TPR repeat; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..829
FT                   /note="Transcription activator GutR"
FT                   /id="PRO_0000083879"
FT   REPEAT          697..730
FT                   /note="TPR 1"
FT   REPEAT          736..769
FT                   /note="TPR 2"
FT   REPEAT          775..808
FT                   /note="TPR 3"
FT   DNA_BIND        42..61
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000250"
FT   BINDING         200..207
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255"
FT   VARIANT         289
FT                   /note="S -> R (in gutR1; results in the constitutive
FT                   expression of gutB)"
SQ   SEQUENCE   829 AA;  95076 MW;  2AF1B18F043EFA51 CRC64;
     MAELENRKQF AQMLAPGVKT LKLHPDYKVR RKKNEKTGQS YIDKIALQLG VSPNTIKSWI
     GQMGANYIPG RIDDGKLFGM IWIILEKTDL DIEWLTDLLE ATTIPVIKPA LPVWAASCLK
     KAKILRKDGL FGAPSEGEIE NVVKRLFHDR PGQETNALTE QPITHNLPSR WSGRFIGRSF
     DMEAIRQWML SPSPVCLITG WAGMGKTTIA LEAAYSCVDD TSVWPAFNSI IWVSADWKGL
     SFSDFLNTIA YQLGRKEQID KSINVKRFVV RNALANYTRE KPILLIVDSI DTAERDIHEF
     ITSLPQGVKV LLTARENVKQ TYRESFGEMT AIQLSGLDQT DAHEFFQQEV HHCLQTCNLP
     RKREKLEQLL HLSSDLKNEF ISATAGNPKA MALSIAYMSD DDIPAQQLIH ELGKAGYSLL
     ELFEFLFGRT WDRCNEDTRK LWQTLCFFSK PPDEKSLAAA AGLDARRFHY AMEQMRSYAL
     IQPERSQGRT QYLAHQTVVA YGEQHLSEQH EYEKEARNRW AHYYIDYAET HLKREQPNSI
     YWSYLLGRNL DQMKQEWPNI LKVIQWASET EQKEILIELI TRISHFLSRI NLPLRIEYGR
     KAADAAHHLG QHTREAYFRI DTSGWALMEV NDLDGALQQI EAGLKILEQS DAHDAYDLKV
     WGHALKARLF LKDGQQEKAE TILNEIENQP ISPTIQHRVL LVRGDLSFAR GYHVEAIQLY
     EAANEISSTY GGEKTIEAYF NLGVAYVKCD QFEKAEEAFE QMLYDKHNAN QVELIYYHYG
     MAQLLYRKGE KTKAVESNQK AIRLIDSWEP AIGIRGEVER LARATKENE