ID   GVIN1_HUMAN             Reviewed;        2422 AA.
AC   Q7Z2Y8; A6NFL2; Q9H8N5;
DT   18-MAR-2008, integrated into UniProtKB/Swiss-Prot.
DT   18-MAR-2008, sequence version 2.
DT   03-AUG-2022, entry version 96.
DE   RecName: Full=Interferon-induced very large GTPase 1;
DE   AltName: Full=Interferon-induced very large GTPase pseudogene 1;
GN   Name=GVINP1; Synonyms=GVIN1, VLIG1;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16554811; DOI=10.1038/nature04632;
RA   Taylor T.D., Noguchi H., Totoki Y., Toyoda A., Kuroki Y., Dewar K.,
RA   Lloyd C., Itoh T., Takeda T., Kim D.-W., She X., Barlow K.F., Bloom T.,
RA   Bruford E., Chang J.L., Cuomo C.A., Eichler E., FitzGerald M.G.,
RA   Jaffe D.B., LaButti K., Nicol R., Park H.-S., Seaman C., Sougnez C.,
RA   Yang X., Zimmer A.R., Zody M.C., Birren B.W., Nusbaum C., Fujiyama A.,
RA   Hattori M., Rogers J., Lander E.S., Sakaki Y.;
RT   "Human chromosome 11 DNA sequence and analysis including novel gene
RT   identification.";
RL   Nature 440:497-500(2006).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1301-2422.
RC   TISSUE=Small intestine;
RX   PubMed=17974005; DOI=10.1186/1471-2164-8-399;
RA   Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U.,
RA   Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D.,
RA   Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A.,
RA   Wiemann S., Schupp I.;
RT   "The full-ORF clone resource of the German cDNA consortium.";
RL   BMC Genomics 8:399-399(2007).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1806-2422.
RC   TISSUE=Placenta;
RX   PubMed=14702039; DOI=10.1038/ng1285;
RA   Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA   Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA   Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA   Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA   Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA   Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA   Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA   Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA   Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA   Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA   Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA   Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA   Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA   Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA   Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA   Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA   Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA   Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA   Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA   Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA   Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA   Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA   Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA   Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA   Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA   Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA   Isogai T., Sugano S.;
RT   "Complete sequencing and characterization of 21,243 full-length human
RT   cDNAs.";
RL   Nat. Genet. 36:40-45(2004).
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000250}. Nucleus
CC       {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the TRAFAC class dynamin-like GTPase
CC       superfamily. Very large inducible GTPase (VLIG) family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=BAB14573.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AC091564; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; BX538342; CAD98105.1; -; mRNA.
DR   EMBL; AK023435; BAB14573.1; ALT_INIT; mRNA.
DR   AlphaFoldDB; Q7Z2Y8; -.
DR   IntAct; Q7Z2Y8; 2.
DR   CarbonylDB; Q7Z2Y8; -.
DR   iPTMnet; Q7Z2Y8; -.
DR   PhosphoSitePlus; Q7Z2Y8; -.
DR   BioMuta; HGNC:25813; -.
DR   DMDM; 172045914; -.
DR   EPD; Q7Z2Y8; -.
DR   MassIVE; Q7Z2Y8; -.
DR   PeptideAtlas; Q7Z2Y8; -.
DR   PRIDE; Q7Z2Y8; -.
DR   ProteomicsDB; 68988; -.
DR   GeneCards; GVINP1; -.
DR   HGNC; HGNC:25813; GVINP1.
DR   MIM; 616121; gene.
DR   neXtProt; NX_Q7Z2Y8; -.
DR   InParanoid; Q7Z2Y8; -.
DR   PhylomeDB; Q7Z2Y8; -.
DR   PathwayCommons; Q7Z2Y8; -.
DR   ChiTaRS; GVINP1; human.
DR   Pharos; Q7Z2Y8; Tdark.
DR   PRO; PR:Q7Z2Y8; -.
DR   Proteomes; UP000005640; Unplaced.
DR   RNAct; Q7Z2Y8; protein.
DR   GO; GO:0005829; C:cytosol; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR   Gene3D; 3.40.50.300; -; 1.
DR   InterPro; IPR029028; Alpha/beta_knot_MTases.
DR   InterPro; IPR030383; G_VLIG_dom.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   SUPFAM; SSF75217; SSF75217; 1.
DR   PROSITE; PS51717; G_VLIG; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasm; GTP-binding; Nucleotide-binding; Nucleus; Reference proteome.
FT   CHAIN           1..2422
FT                   /note="Interferon-induced very large GTPase 1"
FT                   /id="PRO_0000324578"
FT   DOMAIN          1479..1720
FT                   /note="VLIG-type G"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01054"
FT   REGION          945..965
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        950..965
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   BINDING         1489..1496
FT                   /ligand="GTP"
FT                   /ligand_id="ChEBI:CHEBI:37565"
FT                   /evidence="ECO:0000255"
FT   BINDING         1542..1545
FT                   /ligand="GTP"
FT                   /ligand_id="ChEBI:CHEBI:37565"
FT                   /evidence="ECO:0000255"
FT   BINDING         1619..1622
FT                   /ligand="GTP"
FT                   /ligand_id="ChEBI:CHEBI:37565"
FT                   /evidence="ECO:0000255"
FT   CONFLICT        2087
FT                   /note="V -> I (in Ref. 3; BAB14573)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   2422 AA;  279048 MW;  948FDDEA2DA4F873 CRC64;
     MATGEHTPDD PLLRGKRRQD LQEMLREVGL DVEYWLPKLQ EHLGVTCAQA LQHLDKNNLK
     KLKSQTQHPW EKLLNLSHSK SLSALLQESQ VERAKRKQKQ AEQALQELRD LLTEGKQRQE
     EAVRTREAEL RQAMDIPEEY WPSPEEPLRE LMENLQRQLN LMKWTLCHRQ NLPDRDVVRW
     ASGGLALQGI YKASHQRGLT EKREELLSVP KEFLLLGPQQ GTQMKTKEFT SPQAEFMFTQ
     MVEKLGFRLT TSAKDGNWGF SLEAGLDHSK HPESKETQQS SSENSYFCST KFSYIPLASC
     HFPIDQLQLS KPAVQELKCI EELLSQTTNP DRFSLLRHRI INFFHRFGSH VNQGPLHLGG
     IYWWKAISEG YCTEQLAEVR QQSAEALDIF IRDSYSGFGV KVAAGVNVSD SHSKTATQTK
     TSQNLQTKVQ LSVAQTGGPP EADGLVQWKA GLIASNQTWC VIDRGLQLVP VWDIILSSHR
     SNFKDPLQVA NFLKDSYTAL TSITAQIQNG EELLSAGKEA RVFLEDVKSW EVSDPEEQLK
     KLINFMKMLS QKLKSYDTWI NICLTDSLQN FLVNTINFCK KSSIYKTKCI KSHLRSLLDP
     HIYRVTNFPQ AHFIMQWIFQ SDSEQEQVNI SQFSQLIEIL KETQNNLMEV KVKSESPETV
     EEAQRKSTYE VSLALSCFLN YLQKTEQTDT QLLLLSIAAA AGYHVINNTF QSLLGCDELS
     FLLDEMQTAQ NKYQELKNIC SYRAQAFLVL TGLTATVGDT AISSEEKTQR MSLMRHHMGQ
     SLSKEVAHVL TKPGADHDWE NLEKDLRLLI NGDYEEVTIS SLQMEEVSKQ SLFYGKKQPH
     EPHDNENNKW EMIKNGAFLD LLQHLGLEHY YPKKLSKANF HLIYKTSVYN TQPSSEQELP
     FYFLQKLLMM DYELRYLVFK DDRNTEHQVH PNASDQEDEA FDPYENFFED SDSPTKSSST
     EPSPHIHPVD IQMTIFHCAD NFARQYILAK LSTCQFALPL LVPNPCTSQI EFSLWSLRQI
     TRSWQEARKS PKGKNYYKNQ QMCCVSTSIV SFVRVGNGLS ASKSQIMNCL LSKRKHDVFF
     HRHCTGSRKD CLLMGGMVEI CWFCPGGEDE DRFDNCVTFT NLHGDAKEHE QQLSFLKEVS
     TVIVVLMSAS DDNEGNRKIV RNLWQSSRPL ICLLDDKEAT MTNISGQRMR MGIKNRNEAE
     LTEELTTTIR HLLELSDTAL SLEDCSQIAH QQGFLIDEDQ RDCKEAKEKA QALMAFLGKM
     KLSQIKEKLL PLQGQLWHHW CKKDKELYHL REKGNQSIEQ HKSEIETDKQ IIRHEQLARA
     LPLNDLMQSV LQFLQEHSEI HTKLYFLQWL SVFLDKLTAG HLEELHEKQK YWWSLVQTVK
     QKAPNSHSLI CLQSEIEAIS TEISDCTLGI EQLIREVGQI YEALEEASSI KKIFFSLPQI
     AADLMISGVP IELMDGDAAY VPLTWVAAVF DKVSEKLGDK RLFVLSILGL QSSGKSTVLN
     ALFGLQFTVS AGKCTQGAYM QLLKVEETFT EELGFDFVLA VDTEGLRAPE HSNKSKDRDN
     ELVTFVIGLA NLTLINIFGE NPSEMQDILQ IVVQAFLRMK QVKIFPSCLF VHQNVGEATA
     TDQTMDGRRR LEQKLDEMAA IAAEQEQCLD VTCFSDVIRF DVNTHVYYFA HLWDGNPPMA
     PPNPRYSHNV QQLKSRILMT ATQESRGNIM KISDVKSRVQ DLWRGLMNEN FIFSFRNTQE
     VMAMNKLETM YNHWTWELRS HVLGLQNQLI NQIQNGKIQT LEASTFEVLV TEKYEVVKQE
     LEKYFNEGPC SKILIQCKAN FENKLIVLKE KLISDSKRQA NELISFKNQS QERLNKKKTD
     YEKELLEKSR KLALTVKGKE LSEEELHEKF NQLWKKWVCD VSTTLPQVTE PDIDLDSENI
     LWEYFKNKTN VVGLLTNSAE KFQINYDKHI KVNKKYNHIP MTLTVFEKEF INMTTDYIVS
     RFNKIINNMW KQQCGYNPNY FHEILKTIEE EVKSASTQKR YTFTNTFIID LCVCLFQRAR
     ENFKEMHRAF KRANDPVNYL ESKKDDFFTS FKISCQGATS IKTFVDVLWY KLTPAVSTTI
     WEDMTFKIAG DMRATCPAFN GNRTNLEKHI LFSLAEEENF DNYWEYLHNS KSFFRSYIKN
     HIKRYCSDNG GEKMKTFFEK SLIDIKNTIL SAIHESTSVA KDKSSTASEW LDLFCDCLGC
     NLIFPRRDLI SIEHQEIKHT EFLKEAMSAA LDLTMKKIEQ NYSSKPIEAM VSKIEKMLSE
     HLCGCWKQCP SCGAICTNTI PTHEGDHSVP FHRPQAVNGE EWYETDDFVI DCCTSLVASD
     CLLVLRDGRN FPFKNYRQAG GDYAMWSITP DTSIQLYWKW FVSHFRSNLE EKYQKKFAGK
     GKIPNAWAKI TKQDVLEDLK KQ