GVIN1_MOUSE
ID GVIN1_MOUSE Reviewed; 2427 AA.
AC Q80SU7; Q3U3F2; Q8BL18; Q8CBA9;
DT 18-MAR-2008, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2003, sequence version 1.
DT 03-AUG-2022, entry version 119.
DE RecName: Full=Interferon-induced very large GTPase 1;
DE AltName: Full=Very large-inducible GTPase-1;
DE Short=VLIG-1;
GN Name=Gvin1;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], SUBCELLULAR LOCATION, TISSUE SPECIFICITY,
RP GTP-BINDING, AND INDUCTION.
RC STRAIN=C57BL/6J;
RX PubMed=12874213; DOI=10.4049/jimmunol.171.3.1255;
RA Klamp T., Boehm U., Schenk D., Pfeffer K., Howard J.C.;
RT "A giant GTPase, very large inducible GTPase-1, is inducible by IFNs.";
RL J. Immunol. 171:1255-1265(2003).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J, and NOD; TISSUE=Adipose tissue, and Bone;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [3]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Brown adipose tissue, Heart, Kidney, Liver, Lung, Pancreas, Spleen,
RC and Testis;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000269|PubMed:12874213}.
CC Nucleus {ECO:0000269|PubMed:12874213}.
CC -!- TISSUE SPECIFICITY: Widely expressed. Expressed at low basal level in
CC lung, heart, thymus and spleen; at still lower level in liver, ovary,
CC kidney and brain. Expressed at very weak level in testis. Undetectable
CC in embryo. {ECO:0000269|PubMed:12874213}.
CC -!- INDUCTION: By interferons. Induced both in response to IFN type I (IFN-
CC alpha and -beta) and IFN type II (IFN-gamma).
CC {ECO:0000269|PubMed:12874213}.
CC -!- SIMILARITY: Belongs to the TRAFAC class dynamin-like GTPase
CC superfamily. Very large inducible GTPase (VLIG) family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAC32832.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; AY167972; AAO63456.1; -; mRNA.
DR EMBL; AY167973; AAO59423.1; -; mRNA.
DR EMBL; AY167974; AAO59424.1; -; mRNA.
DR EMBL; AK036418; BAC29422.1; -; mRNA.
DR EMBL; AK046674; BAC32832.1; ALT_INIT; mRNA.
DR EMBL; AK154796; BAE32834.1; -; mRNA.
DR CCDS; CCDS21663.1; -.
DR CCDS; CCDS57577.1; -.
DR RefSeq; NP_001229968.1; NM_001243039.1.
DR RefSeq; NP_001229969.1; NM_001243040.1.
DR RefSeq; XP_017177385.1; XM_017321896.1.
DR AlphaFoldDB; Q80SU7; -.
DR BioGRID; 786086; 4.
DR IntAct; Q80SU7; 3.
DR STRING; 10090.ENSMUSP00000102377; -.
DR iPTMnet; Q80SU7; -.
DR PhosphoSitePlus; Q80SU7; -.
DR EPD; Q80SU7; -.
DR MaxQB; Q80SU7; -.
DR PaxDb; Q80SU7; -.
DR PRIDE; Q80SU7; -.
DR ProteomicsDB; 271369; -.
DR Ensembl; ENSMUST00000106766; ENSMUSP00000102377; ENSMUSG00000078606.
DR Ensembl; ENSMUST00000176467; ENSMUSP00000135898; ENSMUSG00000078606.
DR GeneID; 100042856; -.
DR KEGG; mmu:100042856; -.
DR UCSC; uc033jbi.1; mouse.
DR CTD; 100042856; -.
DR MGI; MGI:1921808; Gvin1.
DR VEuPathDB; HostDB:ENSMUSG00000078606; -.
DR eggNOG; ENOG502QVVR; Eukaryota.
DR GeneTree; ENSGT00940000154393; -.
DR HOGENOM; CLU_001775_0_0_1; -.
DR InParanoid; Q80SU7; -.
DR OMA; HILGFEW; -.
DR OrthoDB; 31942at2759; -.
DR PhylomeDB; Q80SU7; -.
DR TreeFam; TF343170; -.
DR BioGRID-ORCS; 100042856; 0 hits in 30 CRISPR screens.
DR ChiTaRS; Gvin1; mouse.
DR PRO; PR:Q80SU7; -.
DR Proteomes; UP000000589; Chromosome 7.
DR RNAct; Q80SU7; protein.
DR Bgee; ENSMUSG00000078606; Expressed in spleen and 50 other tissues.
DR ExpressionAtlas; Q80SU7; baseline and differential.
DR Genevisible; Q80SU7; MM.
DR GO; GO:0005829; C:cytosol; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR Gene3D; 3.40.50.300; -; 1.
DR InterPro; IPR029028; Alpha/beta_knot_MTases.
DR InterPro; IPR030383; G_VLIG_dom.
DR InterPro; IPR027417; P-loop_NTPase.
DR SUPFAM; SSF52540; SSF52540; 1.
DR SUPFAM; SSF75217; SSF75217; 1.
DR PROSITE; PS51717; G_VLIG; 1.
PE 1: Evidence at protein level;
KW Cytoplasm; GTP-binding; Nucleotide-binding; Nucleus; Reference proteome.
FT CHAIN 1..2427
FT /note="Interferon-induced very large GTPase 1"
FT /id="PRO_0000324579"
FT DOMAIN 1485..1726
FT /note="VLIG-type G"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01054"
FT BINDING 1495..1502
FT /ligand="GTP"
FT /ligand_id="ChEBI:CHEBI:37565"
FT /evidence="ECO:0000255"
FT BINDING 1548..1551
FT /ligand="GTP"
FT /ligand_id="ChEBI:CHEBI:37565"
FT /evidence="ECO:0000255"
FT BINDING 1625..1628
FT /ligand="GTP"
FT /ligand_id="ChEBI:CHEBI:37565"
FT /evidence="ECO:0000255"
FT CONFLICT 602
FT /note="I -> S (in Ref. 2; BAE32834)"
FT /evidence="ECO:0000305"
FT CONFLICT 644
FT /note="K -> R (in Ref. 2; BAE32834)"
FT /evidence="ECO:0000305"
FT CONFLICT 1858
FT /note="I -> V (in Ref. 2; BAC32832)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 2427 AA; 280815 MW; B9C9234B4365627F CRC64;
MATAKCFTDE PQLQSRRKHN LQEMLTEVGL SVDYWLPKLQ EDLGVTSAQA LQYLDRNDLQ
KLKSQTTHTW EKRALEKLLD FSQPNSVAEL QETPREMKKN RQRQAGQALQ ALKALQSEGK
HREEEAVRRK EAELRQAMEI PEECWPTAEV SLKDITEIME RHLSHMERTL AHSPNLSDGD
LVRWASGGLA LQGIYKTNHP RSLIQKREEL LSVPKQFSLV GPEHGTEIKT MEFSSFHEQA
MFTETIKMMG FSSTSLVKGE GWGFSLEAGI DQNEQTASEN THQSHSEQTY FCSARFSYIP
LATCHFHIND LELSNAALQE LKTIEELLEQ TTDHRDGLPL LRHRAENFFH RFGSHANQGP
LQLGGIYCWK AISEGFKSEH LADVKQQTRE SLNIYIMGSY SGFGVKVGAS VNIANSNSET
ASFSTTHLHS QTKVQLSVAQ IGGPAEADGI AQWTAGLVVS NQTWSVIDRE LQLVPIWDII
LSSHRTDFKN ALQVANCLKD NYTALTELDA QIQEGEEFLT ARKEAKLFIE DVKCWEVSDP
EEQLTKLLDF MQTLSQKIKS YNIWINTCLT DWDLQNFLIN TVKFCKTSPT YKTQFIKSQL
CILLEPHVYK VTNFPEAHSI IQWINQSEYG EEQVKITSFS EFIKTLKKTH KYLMEVNFKN
EAPETVEEAE RTATYEVTTA LSSFLKYLKE TEQPDMQLLL LSIAAGAGYQ LVNSIFQHLL
GCDELNFLLD QMQSNQHKYQ ELKNICNYRA QAFLVLTALR TTVEITDIST EEKRQRLALI
KQHMGTLLSE EVAHVLTKHG EHHDWESLEN DLRLLIEGDY KATTHYLQMD EVKKQLQSLC
HGKKQTYKQK SNENITKGMI ENGPFLKLLQ RLGLDNYYPK RMSRADFHLI YKTSVYNSQP
RSEKELPFYF LQKLLMLDYG FRHLIVKDDE NIKKQISIGS SNHENEDIDP YDDVIIDNDS
PGYPSATESW PHIHPLDIQM TILHCADDLT RQYIFSKLSI CHYALPLVVP NPNTSQIEFY
LWSLRQIRKS WQDASKSPQD KSYSHRNQQM CRVSTPIVSF IRVGNDLSAS KSQIMNSLLS
KRKHDVFFHR HCKGSNKHCL LMQGVVEICW FCPAGQGEDT FENCLTFTSL HGDAKEHTQQ
LSFLQHVSSI IVVLMSVSDN NKENQKLVRH LWQSSTPLIC LIDDKEKAIA NTSGKRMRIG
IKNRNEAELT EELTNAIKHF LELSNTVLSL EDCSQTAREL GFIIDEDQRD CKEAKEKAQT
VMALLEEYKL SQTKENLLPL QGQLWHLWCK KDKEFYHLRE KGNRSIEQHK SEIETHKRKI
RRQQLEKAFP LNDLMRSVLE LLQDYSETHN KLYVLQWLTL FFDNLTIDHL DKLHERQRSL
WLRIQTEKQR AQKSNSVQNQ IEAISTEIHN CTLGIEHLLR EVGQIYEALE ETSSSRDSLF
LCLPQIAADL MIAGVPIELM DGDASYVPLK WVAAIFDKIT EKVGDKRLFV LSVLGLQSSG
KSTLLNALFG LQFTVSAGRC TKGAYMQLLK VEETFTEELG FNYVLVIDTE GLRAPELNNK
SQNWDHELAT LVIGLGNLTL INIFGENPSD IQDILQISVQ AFLRMKQVKI SPSCLFVHQN
VGEVTAKDQT MEGRKRLEQK LDEMTALAAE LEECSNITRF SDVIKFDANR HVYYFAHLWD
GNPPMAPPNP RYSYNVQELR NEILSTAQQE SRGRILKISD FKFRVQDLWK ALVSENFIFS
FRNTQEVIAM SKLETKYNEW TWELRSHVLD LQNQLDNQIQ NGKILTLTSN LLEEPLSRKL
KTIKEEFDKY FEEDPDCEIL VQWKANFEHK LLILKDSLIS DTRQKCNEHI SLKNSQEILD
NQKSQYENQL LERSRKLALN LKGKELSDEE LHEKFRQLWT SWIYDVSSNV PHVTEPNIDL
DSENILLEYF KKDKNIVERL KIKSQGKFEI MYDKHIQMKK KYLLLRKSLE TCHVESIKKT
TNNIQLKFTE TLTNIWKQKR DYSQNYFHEI LRIIENELKS EPCEGDYTFT KDYIIDLSLY
LFQRASKDFK KMHAAFKTAN DPVNYLERKK DDFFMSFKIS CQGATSITSF VDFLWLKLTP
AISVSIWKIM VQKIAGDMRA TCPEFNGNRA NLEIHILYSL AEEEKFDKYW KYIQKPEEFF
RDYIRDHIKR YCSEKESEKI KTFLNISLGD IKNTILSAIH NSTKVAKAKG STASHWLDLF
CDHLGSNLVF PRKDLVSIEH QELMDTEFLK EAMSKALDPA MREVEEDCSS KHIDEIVPDI
EKILSEHLCG CWKQCPFCKA ICTNTIPQHE GDHSVPFHRP QAVSGWHWHK TDQFHINVCT
SSVASNISFI LDGFREFPFK KYREAGGDYA TWSITPDSST QPYWKWFVCH FRSNLEENYG
KKFTGKGSLP DLWTKITKQE VLNDLKK
