AMT_CORGL
ID AMT_CORGL Reviewed; 452 AA.
AC P54146;
DT 01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-1996, sequence version 1.
DT 03-AUG-2022, entry version 132.
DE RecName: Full=Ammonium transporter {ECO:0000250|UniProtKB:P69681};
DE AltName: Full=Ammonia channel {ECO:0000250|UniProtKB:P69681};
DE AltName: Full=Ammonium channel {ECO:0000250|UniProtKB:P69681};
GN Name=amt; OrderedLocusNames=Cgl1583, cg1785;
OS Corynebacterium glutamicum (strain ATCC 13032 / DSM 20300 / BCRC 11384 /
OS JCM 1318 / LMG 3730 / NCIMB 10025).
OC Bacteria; Actinobacteria; Corynebacteriales; Corynebacteriaceae;
OC Corynebacterium.
OX NCBI_TaxID=196627;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=ATCC 13032 / DSM 20300 / BCRC 11384 / JCM 1318 / LMG 3730 / NCIMB
RC 10025;
RX PubMed=8621394; DOI=10.1074/jbc.271.10.5398;
RA Siewe R.M., Weil B., Burkovski A., Eikmanns B.J., Eikmanns M., Kraemer R.;
RT "Functional and genetic characterization of the (methyl)ammonium uptake
RT carrier of Corynebacterium glutamicum.";
RL J. Biol. Chem. 271:5398-5403(1996).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 13032 / DSM 20300 / BCRC 11384 / JCM 1318 / LMG 3730 / NCIMB
RC 10025;
RX PubMed=12743753; DOI=10.1007/s00253-003-1328-1;
RA Ikeda M., Nakagawa S.;
RT "The Corynebacterium glutamicum genome: features and impacts on
RT biotechnological processes.";
RL Appl. Microbiol. Biotechnol. 62:99-109(2003).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 13032 / DSM 20300 / BCRC 11384 / JCM 1318 / LMG 3730 / NCIMB
RC 10025;
RX PubMed=12948626; DOI=10.1016/s0168-1656(03)00154-8;
RA Kalinowski J., Bathe B., Bartels D., Bischoff N., Bott M., Burkovski A.,
RA Dusch N., Eggeling L., Eikmanns B.J., Gaigalat L., Goesmann A.,
RA Hartmann M., Huthmacher K., Kraemer R., Linke B., McHardy A.C., Meyer F.,
RA Moeckel B., Pfefferle W., Puehler A., Rey D.A., Rueckert C., Rupp O.,
RA Sahm H., Wendisch V.F., Wiegraebe I., Tauch A.;
RT "The complete Corynebacterium glutamicum ATCC 13032 genome sequence and its
RT impact on the production of L-aspartate-derived amino acids and vitamins.";
RL J. Biotechnol. 104:5-25(2003).
RN [4]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-148.
RC STRAIN=ATCC 13032 / DSM 20300 / BCRC 11384 / JCM 1318 / LMG 3730 / NCIMB
RC 10025;
RX PubMed=2666264; DOI=10.1016/0378-1119(89)90072-3;
RA O'Regan M., Thierbach G., Bachmann B., Villeval D., Lepage P., Viret J.F.,
RA Lemoine Y.;
RT "Cloning and nucleotide sequence of the phosphoenolpyruvate carboxylase-
RT coding gene of Corynebacterium glutamicum ATCC13032.";
RL Gene 77:237-251(1989).
CC -!- FUNCTION: Involved in the uptake of ammonium/ammonia (NH(4)(+)/NH(3)).
CC {ECO:0000250|UniProtKB:P69681}.
CC -!- SUBUNIT: Homotrimer. {ECO:0000250|UniProtKB:P69681}.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- INDUCTION: By nitrogen starvation.
CC -!- SIMILARITY: Belongs to the ammonia transporter channel (TC 1.A.11.2)
CC family. {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; X93513; CAA63770.1; -; Genomic_DNA.
DR EMBL; BA000036; BAB98976.1; -; Genomic_DNA.
DR EMBL; BX927152; CAF21591.1; -; Genomic_DNA.
DR RefSeq; NP_600797.1; NC_003450.3.
DR RefSeq; WP_011014463.1; NC_006958.1.
DR AlphaFoldDB; P54146; -.
DR SMR; P54146; -.
DR STRING; 196627.cg1785; -.
DR TCDB; 1.A.11.1.2; the ammonium transporter channel (amt) family.
DR KEGG; cgb:cg1785; -.
DR KEGG; cgl:Cgl1583; -.
DR PATRIC; fig|196627.13.peg.1544; -.
DR eggNOG; COG0004; Bacteria.
DR HOGENOM; CLU_000445_33_0_11; -.
DR OMA; MLFLLCW; -.
DR Proteomes; UP000000582; Chromosome.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0008519; F:ammonium transmembrane transporter activity; IEA:InterPro.
DR Gene3D; 1.10.3430.10; -; 1.
DR InterPro; IPR029020; Ammonium/urea_transptr.
DR InterPro; IPR001905; Ammonium_transpt.
DR InterPro; IPR018047; Ammonium_transpt_CS.
DR InterPro; IPR024041; NH4_transpt_AmtB-like_dom.
DR PANTHER; PTHR43029; PTHR43029; 1.
DR Pfam; PF00909; Ammonium_transp; 1.
DR TIGRFAMs; TIGR00836; amt; 1.
DR PROSITE; PS01219; AMMONIUM_TRANSP; 1.
PE 2: Evidence at transcript level;
KW Ammonia transport; Cell membrane; Membrane; Reference proteome;
KW Stress response; Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..452
FT /note="Ammonium transporter"
FT /id="PRO_0000139757"
FT TRANSMEM 6..26
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 43..63
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 94..114
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 126..146
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 167..187
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 201..221
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 228..248
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 259..279
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 282..302
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 314..334
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 336..356
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 360..380
FT /note="Helical"
FT /evidence="ECO:0000255"
SQ SEQUENCE 452 AA; 47699 MW; F0DF88A35B525519 CRC64;
MDPSDLAWIL AAFALVSLMF PGLSLLYGGM LGGQHVLNTF MMVMSSLGII SLVYIIYGHG
LVLGNSIGGW GIIGNPLEYF GFRNIMEDDG TGDLMWAGFY ILFAAISLAL VSSGAAGRMR
FGAWLVFGVL WFTFVYAPLA HWVFAIDDPE SGYVGGWMKN VLEFHDFAGG TAVHMNAGAS
GLALAIVLGR RHSMAVRPHN LPLILIGAGL IVAGWFGFNG GTAGGANFLA SYVVVTSLIA
AAGGMMGFML VERVFSGKPT FFGSATGTIA GLVAITPAAD AVSPLGAFAV GALGAVVSFW
AISWKKGHRV DDSFDVFAVH GMAGIAGALF VMLFGDPLAP AGVSGVFFGG ELSLLWREPL
AIIVTLTYAF GVTWLIATIL NKFMTLRITS EAEYEGIDRA EHAESAYHLN SNGIGMATRT
NFGPEIPEET VPDAVQVGVD KQKIADTRKA SK
