ID   AMT_MYCBO               Reviewed;         477 AA.
AC   P63520; A0A1R3Y4K9; Q10968; X2BMS9;
DT   11-OCT-2004, integrated into UniProtKB/Swiss-Prot.
DT   11-OCT-2004, sequence version 1.
DT   25-MAY-2022, entry version 102.
DE   RecName: Full=Ammonium transporter {ECO:0000250|UniProtKB:P69681};
DE   AltName: Full=Ammonia channel {ECO:0000250|UniProtKB:P69681};
DE   AltName: Full=Ammonium channel {ECO:0000250|UniProtKB:P69681};
GN   Name=amt; OrderedLocusNames=BQ2027_MB2944C;
OS   Mycobacterium bovis (strain ATCC BAA-935 / AF2122/97).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium tuberculosis complex.
OX   NCBI_TaxID=233413;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-935 / AF2122/97;
RX   PubMed=12788972; DOI=10.1073/pnas.1130426100;
RA   Garnier T., Eiglmeier K., Camus J.-C., Medina N., Mansoor H., Pryor M.,
RA   Duthoy S., Grondin S., Lacroix C., Monsempe C., Simon S., Harris B.,
RA   Atkin R., Doggett J., Mayes R., Keating L., Wheeler P.R., Parkhill J.,
RA   Barrell B.G., Cole S.T., Gordon S.V., Hewinson R.G.;
RT   "The complete genome sequence of Mycobacterium bovis.";
RL   Proc. Natl. Acad. Sci. U.S.A. 100:7877-7882(2003).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND GENOME REANNOTATION.
RC   STRAIN=ATCC BAA-935 / AF2122/97;
RX   PubMed=28385856; DOI=10.1128/genomea.00157-17;
RA   Malone K.M., Farrell D., Stuber T.P., Schubert O.T., Aebersold R.,
RA   Robbe-Austerman S., Gordon S.V.;
RT   "Updated reference genome sequence and annotation of Mycobacterium bovis
RT   AF2122/97.";
RL   Genome Announc. 5:E00157-E00157(2017).
CC   -!- FUNCTION: Involved in the uptake of ammonium/ammonia (NH(4)(+)/NH(3)).
CC       {ECO:0000250|UniProtKB:P69681}.
CC   -!- SUBUNIT: Homotrimer. {ECO:0000250|UniProtKB:P69681}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the ammonia transporter channel (TC 1.A.11.2)
CC       family. {ECO:0000305}.
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DR   EMBL; LT708304; SIU01565.1; -; Genomic_DNA.
DR   RefSeq; NP_856589.1; NC_002945.3.
DR   RefSeq; WP_003899540.1; NC_002945.4.
DR   AlphaFoldDB; P63520; -.
DR   SMR; P63520; -.
DR   EnsemblBacteria; SIU01565; SIU01565; BQ2027_MB2944C.
DR   GeneID; 45426907; -.
DR   PATRIC; fig|233413.5.peg.3230; -.
DR   OMA; MACWNSN; -.
DR   Proteomes; UP000001419; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0008519; F:ammonium transmembrane transporter activity; IEA:InterPro.
DR   Gene3D; 1.10.3430.10; -; 1.
DR   InterPro; IPR029020; Ammonium/urea_transptr.
DR   InterPro; IPR001905; Ammonium_transpt.
DR   InterPro; IPR018047; Ammonium_transpt_CS.
DR   InterPro; IPR024041; NH4_transpt_AmtB-like_dom.
DR   PANTHER; PTHR43029; PTHR43029; 1.
DR   Pfam; PF00909; Ammonium_transp; 1.
DR   TIGRFAMs; TIGR00836; amt; 1.
DR   PROSITE; PS01219; AMMONIUM_TRANSP; 1.
PE   3: Inferred from homology;
KW   Ammonia transport; Cell membrane; Membrane; Transmembrane;
KW   Transmembrane helix; Transport.
FT   CHAIN           1..477
FT                   /note="Ammonium transporter"
FT                   /id="PRO_0000139759"
FT   TRANSMEM        16..36
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        53..73
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        121..141
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        150..170
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        192..212
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        229..249
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        257..277
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        290..310
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        312..332
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        344..364
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        394..414
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   REGION          456..477
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        460..477
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   477 AA;  49241 MW;  97CB46A1C1063DFB CRC64;
     MDQFPIMGVP DGGDTAWMLV SSALVLLMTP GLAFFYGGMV RSKSVLNMIM MSISAMGVVT
     VLWALYGYSI AFGDDVGNIA GNPSQYWGLK GLIGVNAVAA DPSTQTAAVN IPLAGTLPAT
     VFVAFQLMFA IITVALISGA VADRLKFGAW LLFAGLWATF VYFPVAHWVF AFDGFAAEHG
     GWIANKLHAI DFAGGTAVHI NAGVAALMLA IVLGKRRGWP ATLFRPHNLP FVMLGAALLW
     FGWYGFNAGS ATTANGVAGA TFVTTTIATA AAMLGWLLTE RVRDGKATTL GAASGIVAGL
     VAITPSCSSV NVLGALAVGV SAGVLCALAV GLKFKLGFDD SLDVVGVHLV GGLVGTLLVG
     LLAAPEAPAI NGVAGVSKGL FYGGGFAQLE RQALGACSVL VYSGIITLIL ALILKFTIGL
     RLDAEQESTG IDEAEHAESG YDFAVASGSV LPPRVTVEDS RNGIQERIGQ KVEAEPK