GXCH_DICDI
ID GXCH_DICDI Reviewed; 928 AA.
AC Q54J14;
DT 16-JUN-2009, integrated into UniProtKB/Swiss-Prot.
DT 24-MAY-2005, sequence version 1.
DT 25-MAY-2022, entry version 93.
DE RecName: Full=RhoGEF domain-containing protein gxcH;
GN Name=gxcH; ORFNames=DDB_0187910, DDB_0233496;
OS Dictyostelium discoideum (Slime mold).
OC Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC Dictyosteliaceae; Dictyostelium.
OX NCBI_TaxID=44689;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=15875012; DOI=10.1038/nature03481;
RA Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT "The genome of the social amoeba Dictyostelium discoideum.";
RL Nature 435:43-57(2005).
CC -!- FUNCTION: GTPase-activating protein. {ECO:0000250}.
CC -!- DOMAIN: The PH-like region is similar to the PH domain but is not
CC detected by Pfam and PROSITE prediction tools. It is unclear whether it
CC is a real PH domain.
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DR EMBL; AAFI02000111; EAL63214.1; -; Genomic_DNA.
DR RefSeq; XP_636716.1; XM_631624.1.
DR AlphaFoldDB; Q54J14; -.
DR SMR; Q54J14; -.
DR STRING; 44689.DDB0233496; -.
DR PaxDb; Q54J14; -.
DR EnsemblProtists; EAL63214; EAL63214; DDB_G0288377.
DR GeneID; 8626592; -.
DR KEGG; ddi:DDB_G0288377; -.
DR dictyBase; DDB_G0288377; gxcH.
DR eggNOG; KOG3519; Eukaryota.
DR HOGENOM; CLU_315099_0_0_1; -.
DR InParanoid; Q54J14; -.
DR PRO; PR:Q54J14; -.
DR Proteomes; UP000002195; Chromosome 5.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR CDD; cd00160; RhoGEF; 1.
DR Gene3D; 1.20.900.10; -; 1.
DR InterPro; IPR035899; DBL_dom_sf.
DR InterPro; IPR000219; DH-domain.
DR Pfam; PF00621; RhoGEF; 1.
DR SMART; SM00325; RhoGEF; 1.
DR SUPFAM; SSF48065; SSF48065; 1.
DR PROSITE; PS50010; DH_2; 1.
PE 3: Inferred from homology;
KW Guanine-nucleotide releasing factor; Reference proteome.
FT CHAIN 1..928
FT /note="RhoGEF domain-containing protein gxcH"
FT /id="PRO_0000377436"
FT DOMAIN 484..671
FT /note="DH"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00062"
FT REGION 30..76
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 90..201
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 318..410
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 699..807
FT /note="PH-like"
FT REGION 835..928
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 30..48
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 124..142
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 174..201
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 319..335
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 336..366
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 379..410
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 848..895
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 899..920
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 928 AA; 105842 MW; 38EF18BE811CC9E6 CRC64;
MENINIEYGI DSNLNLDKFQ DNEMEIKNLS KSFDNNNNNN SNTNNIKNNN RERSRRKSLS
MPLLEPLPKP KRPPVPPRAF LMNDGADEKI TNYIPTTPPS INITFEKKED GDNYDDNYDD
NYSGEDIKTS TTPPQFNSPE FNKNKPLPPI PIDQEKEDYH TMAPKPLPRV PSKIETFNDQ
NNNEGLQNST SPLSSSPPPL GNLLNTSNGW RSANKPIDSS FSNIAPKRST TLFDVTNPTI
FPSSLNSSGS CCSSSGSGGK SPSNFLNFEP SKPNFENFDD YVFGNDSSEL SQSQISPVVR
TRRQRVFTRK AATMKLLDNG VDTDDENESE LSKKSGTTLD SEPNLKSVSS SNRGSFVISK
SSYNLRGSCS DEDDQENQTT NKNNSNNNNN NTTTNNNNNN NNNNNNNKDT LKVTETKHGR
TVSLPEEPVS TLIPNATVSK KRPSLFNKFD FKSVIFEKIE EQQQKFESIP SRRSQLPYIN
DSTIFNKVVK EIIETEADYL DHMEITINFY LFAALEMVKY KILEKRDIFS IFSNFEEVYH
ISLKIYPMLL NCIPLLEKNQ YPNIEEVFLF NSKSFQRYGS YLSSHDSCNK FLQEILLTNQ
TAAQIFQKLI PICKLNNLHS FLIKPCQRLC KYPLLLKELS KALPKEDEQN HKTIKRTTSL
MGKIVSDING KMKNDTKIQE IIKEIGTKDI EYLLHHQTFI GEGKVKKVNK NGSTSEGTLY
LFNQRIVFAE KNSLFNKKAT VISLSNISRV CDYDYRYPSG FAIYHNSKKV STSSSSNLGT
LSLGALIIIS DEKLKWMNKI EDQIVSERVL AGTYTYVTNH FESFKNLENC SFSQSDSQSD
FVDHDIQQEQ QEQQQQQQEE EQTRVKIPQI VEPLSQQHDQ PKLDHQQSSI QPKLSFPHLK
QPKQDEKPIK KPKSPKHKNT EPENFSFY
