ID   GXCI_DICDI              Reviewed;        1082 AA.
AC   Q54J11;
DT   16-JUN-2009, integrated into UniProtKB/Swiss-Prot.
DT   16-JUN-2009, sequence version 3.
DT   03-AUG-2022, entry version 91.
DE   RecName: Full=RhoGEF domain-containing protein gxcI;
GN   Name=gxcI; ORFNames=DDB_0233474;
OS   Dictyostelium discoideum (Slime mold).
OC   Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC   Dictyosteliaceae; Dictyostelium.
OX   NCBI_TaxID=44689;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AX4;
RX   PubMed=15875012; DOI=10.1038/nature03481;
RA   Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA   Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA   Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA   Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA   Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA   Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA   Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA   Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA   Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA   Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA   Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA   Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA   Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA   Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA   Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA   Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA   Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT   "The genome of the social amoeba Dictyostelium discoideum.";
RL   Nature 435:43-57(2005).
CC   -!- FUNCTION: GTPase-activating protein. {ECO:0000250}.
CC   -!- DOMAIN: The PH-like region is similar to the PH domain but contains an
CC       insert. It is unclear whether it is a real PH domain.
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DR   EMBL; AAFI02000111; EAL63217.3; -; Genomic_DNA.
DR   RefSeq; XP_636719.3; XM_631627.3.
DR   AlphaFoldDB; Q54J11; -.
DR   SMR; Q54J11; -.
DR   STRING; 44689.DDB0304693; -.
DR   PaxDb; Q54J11; -.
DR   EnsemblProtists; EAL63217; EAL63217; DDB_G0288383.
DR   GeneID; 8626595; -.
DR   KEGG; ddi:DDB_G0288383; -.
DR   dictyBase; DDB_G0288383; gxcI.
DR   eggNOG; KOG3519; Eukaryota.
DR   HOGENOM; CLU_285976_0_0_1; -.
DR   InParanoid; Q54J11; -.
DR   OMA; SQLSAXA; -.
DR   Reactome; R-DDI-193648; NRAGE signals death through JNK.
DR   Reactome; R-DDI-9013148; CDC42 GTPase cycle.
DR   Reactome; R-DDI-9013406; RHOQ GTPase cycle.
DR   PRO; PR:Q54J11; -.
DR   Proteomes; UP000002195; Chromosome 5.
DR   GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR   GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IBA:GO_Central.
DR   CDD; cd00160; RhoGEF; 1.
DR   Gene3D; 1.20.900.10; -; 1.
DR   InterPro; IPR035899; DBL_dom_sf.
DR   InterPro; IPR000219; DH-domain.
DR   Pfam; PF00621; RhoGEF; 1.
DR   SMART; SM00325; RhoGEF; 1.
DR   SUPFAM; SSF48065; SSF48065; 1.
DR   PROSITE; PS50010; DH_2; 1.
PE   3: Inferred from homology;
KW   Guanine-nucleotide releasing factor; Reference proteome.
FT   CHAIN           1..1082
FT                   /note="RhoGEF domain-containing protein gxcI"
FT                   /id="PRO_0000377435"
FT   DOMAIN          622..817
FT                   /note="DH"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00062"
FT   REGION          1..29
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          59..78
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          91..395
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          438..488
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          504..524
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          838..994
FT                   /note="PH-like"
FT   REGION          920..961
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1017..1060
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        91..160
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        161..205
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        206..255
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        263..280
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        281..368
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        369..383
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        438..469
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1082 AA;  119579 MW;  7A5EEE2295501560 CRC64;
     MRKNSTSNPS PSHQFLTPPK NTTTVVNNNN NTFVNKNKII NENSNQKMFS VGSLVNQIDK
     NQQQQQQQQQ QTHQVLPQRK FSGVSTMISK YNEQQPSSSS STASSSSSPS LPPKPLLSTI
     NNINNSGSAN NNTPSNLSPN TLSPTSIIKK NNNNNISGSP SPSPSPAPTP TILSPLPSPR
     RQLPTRPPSP LPKLPSRPTS PVPPNPDEAL NTTTTNNNNN NNNNNNNNNN NNNNNNNNNN
     NNNNSDNNYI SKLGSHSVKT LPIPPPNDKP APPPRPWSSS GTLTTPPTIA TTKTSTNINS
     TNVKYQTLSP SSTTATTATT TTTINNNVTT PPTTPPSQTI AFNNNNNNNN NNNNNNNNNN
     NSNNNKPLPP TSTKPPRPKI APRNDISPIP VTSLSTANIT NTPTVVIEQT PIIAPIQDSQ
     NIAASDLRTL RQRTFTRKQA SMKLNGEDFS SLSLSTTPTS VSPSTPSSAN PTPSTTPPSM
     SPSNSVSNEF LTINSNENIN NDLINSFNSD DSNNSNNSNS SLSLASASSS ASTTTTSTNS
     LNDTSFNNIS ININPNNGLS VSNFISSHKK KTSFISGTLR RDTLDIKTIL IEKINVQYTI
     TTQLSQKPSR KSLLPPINSS TSFNKVIKEI IETEADYIDQ MEVIINLYYF AALEMSKYKL
     MTANDIYQIF SNIEELYYVS LRLYPMLLNI IPVLDHENQY PNIEEIFLYN SKAFQRYGSY
     LSTHDHSIKV LNSLIDGNNV VNQIFQYVKS LPHSKQLNLQ SFLIKPCQRL CKYPLLLREL
     KKALPPEDDS LEAEEHHKIF QRSLILMEKI VNDINGKMAN DNKIQSTVKE IGTKDIEQQL
     RDQTFLKSSN RIKKLKKKGN KVIVTLYLLS QILIIFEKGT FKKKVKIIPL KNILEIIDIE
     RELQFGISIN YLNDNDIQNN NNNNQNNLSS TNDTTSSTPP TTTTTTNSTP TTTTTTTNST
     PTVNVNTLSI KLSCDNYQDK LIWLNDIDEA INILKILTGS YKFNVSEKDI NININNNNNN
     NNNNNNNNNN NNNNNNNNNN NNNNNINENN INENNINSNN TSLENSGECI NNNINNNNNT
     SN