ID   GXCJJ_DICDI             Reviewed;        1173 AA.
AC   Q553D3;
DT   03-NOV-2009, integrated into UniProtKB/Swiss-Prot.
DT   24-MAY-2005, sequence version 1.
DT   25-MAY-2022, entry version 93.
DE   RecName: Full=Rac guanine nucleotide exchange factor JJ;
DE            Short=RacGEF JJ;
GN   Name=gxcJJ; ORFNames=DDB_G0275679;
OS   Dictyostelium discoideum (Slime mold).
OC   Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC   Dictyosteliaceae; Dictyostelium.
OX   NCBI_TaxID=44689;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AX4;
RX   PubMed=12097910; DOI=10.1038/nature00847;
RA   Gloeckner G., Eichinger L., Szafranski K., Pachebat J.A., Bankier A.T.,
RA   Dear P.H., Lehmann R., Baumgart C., Parra G., Abril J.F., Guigo R.,
RA   Kumpf K., Tunggal B., Cox E.C., Quail M.A., Platzer M., Rosenthal A.,
RA   Noegel A.A.;
RT   "Sequence and analysis of chromosome 2 of Dictyostelium discoideum.";
RL   Nature 418:79-85(2002).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AX4;
RX   PubMed=15875012; DOI=10.1038/nature03481;
RA   Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA   Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA   Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA   Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA   Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA   Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA   Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA   Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA   Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA   Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA   Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA   Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA   Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA   Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA   Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA   Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA   Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT   "The genome of the social amoeba Dictyostelium discoideum.";
RL   Nature 435:43-57(2005).
RN   [3]
RP   PROTEIN SEQUENCE OF 517-524; 570-576; 587-596; 668-688; 821-834; 857-868;
RP   887-902; 960-974; 978-983; 1026-1034 AND 1088-1095, AND IDENTIFICATION BY
RP   MASS SPECTROMETRY.
RC   STRAIN=AX2;
RA   Bienvenut W.V., Sumpton D., Ura S., Insall R.H.;
RL   Submitted (OCT-2008) to UniProtKB.
CC   -!- FUNCTION: GTPase-activating protein. {ECO:0000250}.
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DR   EMBL; AAFI02000013; EAL69590.1; -; Genomic_DNA.
DR   RefSeq; XP_643485.1; XM_638393.1.
DR   AlphaFoldDB; Q553D3; -.
DR   SMR; Q553D3; -.
DR   STRING; 44689.DDB0233356; -.
DR   PaxDb; Q553D3; -.
DR   EnsemblProtists; EAL69590; EAL69590; DDB_G0275679.
DR   GeneID; 8620066; -.
DR   KEGG; ddi:DDB_G0275679; -.
DR   dictyBase; DDB_G0275679; gxcJJ.
DR   eggNOG; KOG4424; Eukaryota.
DR   HOGENOM; CLU_273902_0_0_1; -.
DR   InParanoid; Q553D3; -.
DR   OMA; IPMEVEA; -.
DR   PhylomeDB; Q553D3; -.
DR   Reactome; R-DDI-193648; NRAGE signals death through JNK.
DR   Reactome; R-DDI-9013148; CDC42 GTPase cycle.
DR   Reactome; R-DDI-9013149; RAC1 GTPase cycle.
DR   PRO; PR:Q553D3; -.
DR   Proteomes; UP000002195; Chromosome 2.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR   CDD; cd00160; RhoGEF; 1.
DR   Gene3D; 1.20.900.10; -; 1.
DR   Gene3D; 2.30.29.30; -; 1.
DR   InterPro; IPR035899; DBL_dom_sf.
DR   InterPro; IPR000219; DH-domain.
DR   InterPro; IPR000048; IQ_motif_EF-hand-BS.
DR   InterPro; IPR011993; PH-like_dom_sf.
DR   InterPro; IPR001849; PH_domain.
DR   Pfam; PF00621; RhoGEF; 1.
DR   SMART; SM00233; PH; 1.
DR   SMART; SM00325; RhoGEF; 1.
DR   SUPFAM; SSF48065; SSF48065; 1.
DR   PROSITE; PS50010; DH_2; 1.
DR   PROSITE; PS50096; IQ; 1.
PE   1: Evidence at protein level;
KW   Direct protein sequencing; Guanine-nucleotide releasing factor;
KW   Reference proteome.
FT   CHAIN           1..1173
FT                   /note="Rac guanine nucleotide exchange factor JJ"
FT                   /id="PRO_0000388367"
FT   DOMAIN          793..822
FT                   /note="IQ"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT   DOMAIN          833..1016
FT                   /note="DH"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00062"
FT   DOMAIN          1044..1146
FT                   /note="PH"
FT   REGION          1..380
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          458..479
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          712..765
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1173 AA;  137760 MW;  2C94CEDC5634912A CRC64;
     MSYEYYYQQQ QQQQQQQQQQ QQQPTFDYAS YYDNQQQQHP QPQYPVYDHT AQSNDSQQQH
     YGSSYVDPTY ATTSTTQQQQ QQPSIYDYNT GGNRNSGQYD QYNTTNTTTP NTTQNYDYSN
     TSGNRNSGQY DQYTTTNTTS ANTYGYDNSK THSPTPSSYD YSTNSYYSQQ QQQQPTPTVA
     ATNNTTNTST NYDSYYQPPA QRNSYDYSQT QQQHSPTSSY DYSQVTNNTA TNYDSYYQQP
     TTPTSTSSSS STTTTTTTDN QSKFEKSQSL KNMDHFIKGT PSNTPSATIN SWDYNQQQPQ
     PQQPQSVYNN PSSSTTNTTY NNPSTTTTTS SPTNTNTTYN NPSSATNTNY NNRNSWGYDQ
     STYNNSSYNN NTDTYSNQTQ QQEYQVLYDK KYQEEEEKRR KEYEESWRVY YEQQAAYEKE
     QERIRNEEME KIRIKHEEES NRLKNELEKQ RDEIQKMKDQ LVQQQNASKK KGEEDLKQME
     QAKQAALQWQ QEEMKRQLIE VQKERDLSRK HEEQVRLALL EEQRVIKEKL DEKQQQLISQ
     QQAFQSKLHQ DECSRKVEEE KKCEEMKKRE FELLERNKEL DALKSKLQSD LTTSLKSKED
     LENQRKALEE TTLREKKEIQ IYKQSIDEET KRKKLEIEQA RQQEEKKLKE QQDHINRQKE
     MVDCQQRELL VQINQSKQAT IDSLQPMRNM LSTLNINNKN SPASNIALKN KDDQNINDNL
     PQQKPVIPSR NSSHLPKLSP TIQQPQPQQE QPPQQQQQQQ QQQQQQQQQQ QPVKIVKTYT
     QKELDQIVDG NYRFGDIIRV QRVSRKWLAR KKFKDLVKMK LLSNDPETEN MRNRFKSVNE
     LYSTELSYLN SLLILRDFYF IPMEVEARVT KLFKSEEINK VFSNLKSILQ ISTEITHLLE
     ERLSVSPVKI GDIFVKFAPI FKIYVEYVNN FDKVAPQLKA MTENPQSKKF FSEQRNKSRV
     ATDINSLLIM PVQRCPRYEL LLREILKHTQ EDHVEFKNIK SAYESIKDIN KYINDRKRNV
     DNRAKLLELQ KEIKNAPELI ESHRYFVRES QCNISANKKS ESGGFYLFFF NDMVLVTKKS
     SLFSNYKYVY TIPLKNADIK DISSNDSMIR IIVGSLESID VLIYTISLPS KKDKESWLQD
     LSVELKPKGI EIGQYSSSQL LESQVQFSNS KTK