ID   GXCJ_DICDI              Reviewed;        1155 AA.
AC   Q54B37;
DT   16-JUN-2009, integrated into UniProtKB/Swiss-Prot.
DT   24-MAY-2005, sequence version 1.
DT   03-AUG-2022, entry version 95.
DE   RecName: Full=RhoGEF domain-containing protein gxcJ;
GN   Name=gxcJ; ORFNames=DDB_0233315;
OS   Dictyostelium discoideum (Slime mold).
OC   Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC   Dictyosteliaceae; Dictyostelium.
OX   NCBI_TaxID=44689;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AX4;
RX   PubMed=15875012; DOI=10.1038/nature03481;
RA   Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA   Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA   Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA   Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA   Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA   Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA   Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA   Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA   Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA   Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA   Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA   Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA   Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA   Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA   Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA   Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA   Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT   "The genome of the social amoeba Dictyostelium discoideum.";
RL   Nature 435:43-57(2005).
CC   -!- FUNCTION: GTPase-activating protein. {ECO:0000250}.
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DR   EMBL; AAFI02000224; EAL60488.1; -; Genomic_DNA.
DR   RefSeq; XP_628879.1; XM_628877.1.
DR   AlphaFoldDB; Q54B37; -.
DR   STRING; 44689.DDB0233315; -.
DR   PaxDb; Q54B37; -.
DR   EnsemblProtists; EAL60488; EAL60488; DDB_G0293978.
DR   GeneID; 8629495; -.
DR   KEGG; ddi:DDB_G0293978; -.
DR   dictyBase; DDB_G0293978; gxcJ.
DR   eggNOG; KOG3519; Eukaryota.
DR   HOGENOM; CLU_276011_0_0_1; -.
DR   InParanoid; Q54B37; -.
DR   OMA; PELRGMN; -.
DR   Reactome; R-DDI-193648; NRAGE signals death through JNK.
DR   Reactome; R-DDI-9013148; CDC42 GTPase cycle.
DR   Reactome; R-DDI-9013406; RHOQ GTPase cycle.
DR   PRO; PR:Q54B37; -.
DR   Proteomes; UP000002195; Chromosome 6.
DR   GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR   GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IBA:GO_Central.
DR   CDD; cd00160; RhoGEF; 1.
DR   Gene3D; 1.20.900.10; -; 1.
DR   InterPro; IPR035899; DBL_dom_sf.
DR   InterPro; IPR000219; DH-domain.
DR   Pfam; PF00621; RhoGEF; 1.
DR   SMART; SM00325; RhoGEF; 1.
DR   SUPFAM; SSF48065; SSF48065; 1.
DR   PROSITE; PS50010; DH_2; 1.
PE   3: Inferred from homology;
KW   Coiled coil; Guanine-nucleotide releasing factor; Reference proteome.
FT   CHAIN           1..1155
FT                   /note="RhoGEF domain-containing protein gxcJ"
FT                   /id="PRO_0000377437"
FT   DOMAIN          700..874
FT                   /note="DH"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00062"
FT   REGION          114..216
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          259..333
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          429..460
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          484..508
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          604..639
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1084..1155
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          192..257
FT                   /evidence="ECO:0000255"
FT   COMPBIAS        259..319
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        443..460
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1084..1140
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1155 AA;  127930 MW;  BC01765B3D694494 CRC64;
     MLIHPFIQSF TEIIDNRMKL GNNMEGVIEC KNCQTDTPKC NKVCLTCNSD IGERCWRCNY
     LGKINSKFCF RCNVKLHPTS IPPKDSIQPI PIFTKHPIAS TLLINKSIIP TQSENNSIND
     NNNNNNNNNN NNNNNNNNNN NNNNNNNNNT NNNDSKIIDA TITNTKNNNT TNNNNISNNN
     SSNIISNSNN NNNNNNNNNN NNNNNNNNNN NLNFLKKSTS CDNGSFESIS DSISPIKDII
     NNINNRTKDI EKLNSALPLN KKSNSSTSWS NFNTFKNNSK TNNNNNNNNN NNNNNNNNNN
     NNNYKPTITS SQTQPSLMEN SKDIDKKEKI PSNINNNRST TIIYKYQEDN SEDYTDDGDF
     EEFQINSNLT SESSSIDSLI IKDGVIATTV TSSTINCIND NNFDPDQLSS STSSIKKPKL
     FYSITKKKLV SQSPPPPQPP FLASASSSST TTITTTDSLE KSIKDSTPIA TTLVNDYQNQ
     NQNLNNESAA SSSSLSTTTT TTTTTTTTTL LPDSQTNLNN LIFIEKLNND LSGSIETLNN
     SLNNSLNSLN SSFNFRLNLN SITNNEDKRL SNSSLLDEII DAFPSPPSKN PYISVLNTSG
     GIGSNSNSSN NNNSNSNNIT NSNSSSFSKK NSNNNNNYQP VISLPIPIVN HQQQQQQQQL
     QTAAILGNNN INFIQNPSST STTTTTTTAS TTTILIKSDH RTNLIKEILT TELDYVNDLE
     TIINVFCKPL RDFISNEDSA SIFSNIEQIW QINKQLYENL ISNTLTIGQV FSNMSDSLKV
     YSVYCNYHQK SLDSLNQLLK TPQNESFFDQ LLSKPELRGM GPHSFLIKPV QRICKYPLLL
     KELLKATAED HFDYPQLILA VEKIEKIVGT INSQKKEMET WQRTMQLIQN LKGADNLQLL
     AANRHLILEG SLHLVIGFTE NAEKKNSSLK FKKGVYFLFN DLFLFTKQKG TTYKLLFYTQ
     LDNVLIHANV SNCFPADKSV FSLVEIGVGG RKWTFCNTNS NSSNISNSGN SSGIINSSSS
     SSGSCSNGGN SSGYNNLNNT CGIYSGNSNN NNNNNNNNNN IFSTIQKLIE KTWEDKFMGQ
     SSVSHRLSIP STSSPNNGAS LNGNSSSNSS STSISTVGSP NVTSAAKQQQ QLQQQQQSSK
     KRNRRLVKSL VNIKT