ID   AMT_MYCTU               Reviewed;         477 AA.
AC   P9WQ65; L0TDY4; P63519; Q10968;
DT   16-APR-2014, integrated into UniProtKB/Swiss-Prot.
DT   16-APR-2014, sequence version 1.
DT   03-AUG-2022, entry version 46.
DE   RecName: Full=Ammonium transporter {ECO:0000250|UniProtKB:P69681};
DE   AltName: Full=Ammonia channel {ECO:0000250|UniProtKB:P69681};
DE   AltName: Full=Ammonium channel {ECO:0000250|UniProtKB:P69681};
GN   Name=amt; OrderedLocusNames=Rv2920c; ORFNames=MTCY338.09c;
OS   Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium tuberculosis complex.
OX   NCBI_TaxID=83332;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 25618 / H37Rv;
RX   PubMed=9634230; DOI=10.1038/31159;
RA   Cole S.T., Brosch R., Parkhill J., Garnier T., Churcher C.M., Harris D.E.,
RA   Gordon S.V., Eiglmeier K., Gas S., Barry C.E. III, Tekaia F., Badcock K.,
RA   Basham D., Brown D., Chillingworth T., Connor R., Davies R.M., Devlin K.,
RA   Feltwell T., Gentles S., Hamlin N., Holroyd S., Hornsby T., Jagels K.,
RA   Krogh A., McLean J., Moule S., Murphy L.D., Oliver S., Osborne J.,
RA   Quail M.A., Rajandream M.A., Rogers J., Rutter S., Seeger K., Skelton S.,
RA   Squares S., Squares R., Sulston J.E., Taylor K., Whitehead S.,
RA   Barrell B.G.;
RT   "Deciphering the biology of Mycobacterium tuberculosis from the complete
RT   genome sequence.";
RL   Nature 393:537-544(1998).
CC   -!- FUNCTION: Involved in the uptake of ammonium/ammonia (NH(4)(+)/NH(3)).
CC       {ECO:0000250|UniProtKB:P69681}.
CC   -!- SUBUNIT: Homotrimer. {ECO:0000250|UniProtKB:P69681}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the ammonia transporter channel (TC 1.A.11.2)
CC       family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AL123456; CCP45722.1; -; Genomic_DNA.
DR   PIR; H70747; H70747.
DR   RefSeq; NP_217436.1; NC_000962.3.
DR   RefSeq; WP_003899540.1; NZ_NVQJ01000006.1.
DR   AlphaFoldDB; P9WQ65; -.
DR   SMR; P9WQ65; -.
DR   STRING; 83332.Rv2920c; -.
DR   PaxDb; P9WQ65; -.
DR   DNASU; 887683; -.
DR   GeneID; 45426907; -.
DR   GeneID; 887683; -.
DR   KEGG; mtu:Rv2920c; -.
DR   PATRIC; fig|83332.111.peg.3249; -.
DR   TubercuList; Rv2920c; -.
DR   eggNOG; COG0004; Bacteria.
DR   OMA; MACWNSN; -.
DR   PhylomeDB; P9WQ65; -.
DR   Proteomes; UP000001584; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR   GO; GO:0008519; F:ammonium transmembrane transporter activity; IBA:GO_Central.
DR   GO; GO:0072488; P:ammonium transmembrane transport; IBA:GO_Central.
DR   Gene3D; 1.10.3430.10; -; 1.
DR   InterPro; IPR029020; Ammonium/urea_transptr.
DR   InterPro; IPR001905; Ammonium_transpt.
DR   InterPro; IPR018047; Ammonium_transpt_CS.
DR   InterPro; IPR024041; NH4_transpt_AmtB-like_dom.
DR   PANTHER; PTHR43029; PTHR43029; 1.
DR   Pfam; PF00909; Ammonium_transp; 1.
DR   TIGRFAMs; TIGR00836; amt; 1.
DR   PROSITE; PS01219; AMMONIUM_TRANSP; 1.
PE   3: Inferred from homology;
KW   Ammonia transport; Cell membrane; Membrane; Reference proteome;
KW   Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..477
FT                   /note="Ammonium transporter"
FT                   /id="PRO_0000139758"
FT   TRANSMEM        16..36
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        53..73
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        121..141
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        150..170
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        192..212
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        229..249
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        257..277
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        290..310
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        312..332
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        344..364
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        394..414
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   REGION          456..477
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        460..477
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   477 AA;  49241 MW;  97CB46A1C1063DFB CRC64;
     MDQFPIMGVP DGGDTAWMLV SSALVLLMTP GLAFFYGGMV RSKSVLNMIM MSISAMGVVT
     VLWALYGYSI AFGDDVGNIA GNPSQYWGLK GLIGVNAVAA DPSTQTAAVN IPLAGTLPAT
     VFVAFQLMFA IITVALISGA VADRLKFGAW LLFAGLWATF VYFPVAHWVF AFDGFAAEHG
     GWIANKLHAI DFAGGTAVHI NAGVAALMLA IVLGKRRGWP ATLFRPHNLP FVMLGAALLW
     FGWYGFNAGS ATTANGVAGA TFVTTTIATA AAMLGWLLTE RVRDGKATTL GAASGIVAGL
     VAITPSCSSV NVLGALAVGV SAGVLCALAV GLKFKLGFDD SLDVVGVHLV GGLVGTLLVG
     LLAAPEAPAI NGVAGVSKGL FYGGGFAQLE RQALGACSVL VYSGIITLIL ALILKFTIGL
     RLDAEQESTG IDEAEHAESG YDFAVASGSV LPPRVTVEDS RNGIQERIGQ KVEAEPK