ID   GXN_ACRMI               Reviewed;         338 AA.
AC   D9IQ16;
DT   09-JUL-2014, integrated into UniProtKB/Swiss-Prot.
DT   05-OCT-2010, sequence version 1.
DT   25-MAY-2022, entry version 11.
DE   RecName: Full=Galaxin {ECO:0000312|EMBL:ADI50283.1};
DE   Flags: Precursor;
OS   Acropora millepora (Staghorn coral) (Heteropora millepora).
OC   Eukaryota; Metazoa; Cnidaria; Anthozoa; Hexacorallia; Scleractinia;
OC   Astrocoeniina; Acroporidae; Acropora.
OX   NCBI_TaxID=45264;
RN   [1] {ECO:0000312|EMBL:ADI50283.1}
RP   NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, AND DEVELOPMENTAL STAGE.
RX   PubMed=19638240; DOI=10.1186/1471-2148-9-178;
RA   Reyes-Bermudez A., Lin Z., Hayward D.C., Miller D.J., Ball E.E.;
RT   "Differential expression of three galaxin-related genes during settlement
RT   and metamorphosis in the scleractinian coral Acropora millepora.";
RL   BMC Evol. Biol. 9:178-178(2009).
RN   [2] {ECO:0000305}
RP   PROTEIN SEQUENCE OF 273-322, TISSUE SPECIFICITY, AND IDENTIFICATION BY MASS
RP   SPECTROMETRY.
RX   PubMed=23765379; DOI=10.1093/molbev/mst109;
RA   Ramos-Silva P., Kaandorp J., Huisman L., Marie B., Zanella-Cleon I.,
RA   Guichard N., Miller D.J., Marin F.;
RT   "The skeletal proteome of the coral Acropora millepora: the evolution of
RT   calcification by co-option and domain shuffling.";
RL   Mol. Biol. Evol. 30:2099-2112(2013).
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305|PubMed:23765379}.
CC   -!- TISSUE SPECIFICITY: Component of the acid-insoluble organic matrix of
CC       the aragonitic skeleton (at protein level). Initially, expressed in an
CC       aboral submarginal ring and then along calcifying septa.
CC       {ECO:0000269|PubMed:19638240, ECO:0000269|PubMed:23765379}.
CC   -!- DEVELOPMENTAL STAGE: Weakly expressed in primary, post-settlement
CC       polyps and strongly in adult colonies. Not expressed in prawn stage,
CC       domut stage and presettlement planulae. {ECO:0000269|PubMed:19638240}.
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DR   EMBL; HM163215; ADI50283.1; -; mRNA.
DR   AlphaFoldDB; D9IQ16; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
PE   1: Evidence at protein level;
KW   Direct protein sequencing; Secreted; Signal.
FT   SIGNAL          1..23
FT                   /evidence="ECO:0000255"
FT   CHAIN           24..338
FT                   /note="Galaxin"
FT                   /evidence="ECO:0000255"
FT                   /id="PRO_0000429544"
FT   REGION          30..50
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   338 AA;  35126 MW;  CEF0C4E69AE4AD75 CRC64;
     MKPSGAFLSL CVVLLSLATH CFSFPSDSLR RDAHSDTNAL KSRDRRQAPA PQLSCGGVLY
     NPAAEMCCHG NVEPRVGASP MCCESSSYDP STQMCCEGTV SNKPPGIAMC CGSEAYDANS
     QICCNGNINT KATGPTAQPG CCGEFSYDAA SQLCCDSHPV LMVGSLPSCC GRNGYDANTS
     LCCGDNNVAF VSGPQAACCG DMGYNRNTHL CCDSNVLPMP AMGACCGSWT YSQQTHLCCE
     GVQLYKGMNT GCCGAVGYNQ VNSLCCEGTV VPKSPSKPVC CGTTSYNPLT ELCCDGIAFF
     KTGFIRPTCC GGAIYDATVA RCCDGVPTYN VASCAGLA