AMX_DROME
ID AMX_DROME Reviewed; 284 AA.
AC Q9U4H5; Q9W361;
DT 21-AUG-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-2000, sequence version 1.
DT 03-AUG-2022, entry version 117.
DE RecName: Full=TM2 domain-containing protein almondex;
DE Flags: Precursor;
GN Name=amx; ORFNames=CG12127;
OS Drosophila melanogaster (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7227;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Ovary;
RX PubMed=14595834; DOI=10.1002/gene.10233;
RA Michellod M.-A.E., Forquignon F., Santamaria P., Randsholt N.B.;
RT "Differential requirements for the neurogenic gene almondex during
RT Drosophila melanogaster development.";
RL Genesis 37:113-122(2003).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley;
RX PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A.,
RA An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F.,
RA Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F.,
RA Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
RA Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R.,
RA Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y.,
RA Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T.,
RA Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S.,
RA Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W.,
RA Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M.,
RA Venter J.C.;
RT "The genome sequence of Drosophila melanogaster.";
RL Science 287:2185-2195(2000).
RN [3]
RP GENOME REANNOTATION.
RC STRAIN=Berkeley;
RX PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT review.";
RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Berkeley; TISSUE=Head;
RX PubMed=10731138; DOI=10.1126/science.287.5461.2222;
RA Rubin G.M., Hong L., Brokstein P., Evans-Holm M., Frise E., Stapleton M.,
RA Harvey D.A.;
RT "A Drosophila complementary DNA resource.";
RL Science 287:2222-2224(2000).
CC -!- FUNCTION: Involved in the control of cell fates in the neurectoderm.
CC Acts as a positive regulator of Notch pathway and is required at
CC different levels during development.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the TM2 family. {ECO:0000305}.
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DR EMBL; AF217797; AAF36924.2; -; mRNA.
DR EMBL; AE014298; AAF46474.2; -; Genomic_DNA.
DR EMBL; AF181623; AAD55409.1; -; mRNA.
DR RefSeq; NP_001245591.1; NM_001258662.2.
DR RefSeq; NP_524644.1; NM_079905.3.
DR AlphaFoldDB; Q9U4H5; -.
DR BioGRID; 68680; 2.
DR STRING; 7227.FBpp0071266; -.
DR GlyGen; Q9U4H5; 6 sites.
DR PaxDb; Q9U4H5; -.
DR DNASU; 43869; -.
DR EnsemblMetazoa; FBtr0071331; FBpp0071266; FBgn0000077.
DR EnsemblMetazoa; FBtr0307281; FBpp0298282; FBgn0000077.
DR GeneID; 43869; -.
DR KEGG; dme:Dmel_CG12127; -.
DR UCSC; CG12127-RA; d. melanogaster.
DR CTD; 43869; -.
DR FlyBase; FBgn0000077; amx.
DR VEuPathDB; VectorBase:FBgn0000077; -.
DR eggNOG; KOG4272; Eukaryota.
DR GeneTree; ENSGT00940000158389; -.
DR HOGENOM; CLU_084872_0_0_1; -.
DR InParanoid; Q9U4H5; -.
DR OMA; LLISMHY; -.
DR OrthoDB; 1385397at2759; -.
DR PhylomeDB; Q9U4H5; -.
DR BioGRID-ORCS; 43869; 0 hits in 1 CRISPR screen.
DR GenomeRNAi; 43869; -.
DR PRO; PR:Q9U4H5; -.
DR Proteomes; UP000000803; Chromosome X.
DR Bgee; FBgn0000077; Expressed in saliva-secreting gland and 21 other tissues.
DR ExpressionAtlas; Q9U4H5; baseline and differential.
DR Genevisible; Q9U4H5; DM.
DR GO; GO:0044214; C:spanning component of plasma membrane; ISM:FlyBase.
DR GO; GO:0001713; P:ectodermal cell fate determination; IMP:UniProtKB.
DR GO; GO:0046331; P:lateral inhibition; IMP:FlyBase.
DR GO; GO:0007498; P:mesoderm development; IMP:FlyBase.
DR GO; GO:0007400; P:neuroblast fate determination; IMP:FlyBase.
DR GO; GO:0007219; P:Notch signaling pathway; IEA:UniProtKB-KW.
DR GO; GO:0045747; P:positive regulation of Notch signaling pathway; IMP:UniProtKB.
DR InterPro; IPR007829; TM2.
DR Pfam; PF05154; TM2; 1.
PE 2: Evidence at transcript level;
KW Developmental protein; Glycoprotein; Membrane; Notch signaling pathway;
KW Reference proteome; Signal; Transmembrane; Transmembrane helix.
FT SIGNAL 1..32
FT /evidence="ECO:0000255"
FT CHAIN 33..284
FT /note="TM2 domain-containing protein almondex"
FT /id="PRO_0000298999"
FT TRANSMEM 226..246
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 250..270
FT /note="Helical"
FT /evidence="ECO:0000255"
FT REGION 33..63
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CARBOHYD 53
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 89
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 141
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 194
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 206
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 216
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 284 AA; 31364 MW; 8FB8FFB5733AC851 CRC64;
MRLQRQCIVV NMRSAIVLIM IFVLTGIRNS ETASGGNQMD LSDSKGDHKD NSNASNGNGN
ANDNEVYVPP LVSSMVAKSG GGAGGLLDNI TAYSSSSSSS SSNGNNNMLC PYDKETPCDR
LQFPCIRCNY NHGCIYGRDL NVTCEVINNV QCLGERSFQR QMNCRYCYQT EMWQQSCGQR
SSCNSATDKL FRTNCTVHHD VLCLGNRSFT RNLRCNWTQG YRWSTALLIS LTLGGFGADR
FYLGHWQEGI GKLFSFGGLG VWTIIDVLLI SMHYLGPADG SLYI
