ID   GYLR_STRCO              Reviewed;         254 AA.
AC   P15360;
DT   01-APR-1990, integrated into UniProtKB/Swiss-Prot.
DT   01-APR-1990, sequence version 1.
DT   25-MAY-2022, entry version 130.
DE   RecName: Full=Glycerol operon regulatory protein;
GN   Name=gylR; OrderedLocusNames=SCO1658; ORFNames=SCI46.03;
OS   Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145).
OC   Bacteria; Actinobacteria; Streptomycetales; Streptomycetaceae;
OC   Streptomyces; Streptomyces albidoflavus group.
OX   NCBI_TaxID=100226;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=A3(2) / J802;
RX   PubMed=3225846; DOI=10.1016/0022-2836(88)90356-7;
RA   Smith C.P., Chater K.F.;
RT   "Structure and regulation of controlling sequences for the Streptomyces
RT   coelicolor glycerol operon.";
RL   J. Mol. Biol. 204:569-580(1988).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-471 / A3(2) / M145;
RX   PubMed=12000953; DOI=10.1038/417141a;
RA   Bentley S.D., Chater K.F., Cerdeno-Tarraga A.-M., Challis G.L.,
RA   Thomson N.R., James K.D., Harris D.E., Quail M.A., Kieser H., Harper D.,
RA   Bateman A., Brown S., Chandra G., Chen C.W., Collins M., Cronin A.,
RA   Fraser A., Goble A., Hidalgo J., Hornsby T., Howarth S., Huang C.-H.,
RA   Kieser T., Larke L., Murphy L.D., Oliver K., O'Neil S., Rabbinowitsch E.,
RA   Rajandream M.A., Rutherford K.M., Rutter S., Seeger K., Saunders D.,
RA   Sharp S., Squares R., Squares S., Taylor K., Warren T., Wietzorrek A.,
RA   Woodward J.R., Barrell B.G., Parkhill J., Hopwood D.A.;
RT   "Complete genome sequence of the model actinomycete Streptomyces coelicolor
RT   A3(2).";
RL   Nature 417:141-147(2002).
CC   -!- FUNCTION: May be an activator protein for the gylABX operon.
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DR   EMBL; X14188; CAA32390.1; -; Genomic_DNA.
DR   EMBL; AL939109; CAC18789.1; -; Genomic_DNA.
DR   PIR; S02066; S02066.
DR   RefSeq; NP_625933.1; NC_003888.3.
DR   RefSeq; WP_003977167.1; NZ_VNID01000018.1.
DR   AlphaFoldDB; P15360; -.
DR   SMR; P15360; -.
DR   STRING; 100226.SCO1658; -.
DR   GeneID; 1097089; -.
DR   KEGG; sco:SCO1658; -.
DR   PATRIC; fig|100226.15.peg.1675; -.
DR   eggNOG; COG1414; Bacteria.
DR   HOGENOM; CLU_062618_6_2_11; -.
DR   InParanoid; P15360; -.
DR   OMA; HDRRRMP; -.
DR   PhylomeDB; P15360; -.
DR   Proteomes; UP000001973; Chromosome.
DR   GO; GO:0003677; F:DNA binding; IBA:GO_Central.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IBA:GO_Central.
DR   GO; GO:0006071; P:glycerol metabolic process; IEA:UniProtKB-KW.
DR   GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IBA:GO_Central.
DR   Gene3D; 1.10.10.10; -; 1.
DR   Gene3D; 3.30.450.40; -; 1.
DR   InterPro; IPR029016; GAF-like_dom_sf.
DR   InterPro; IPR014757; Tscrpt_reg_IclR_C.
DR   InterPro; IPR005471; Tscrpt_reg_IclR_N.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   Pfam; PF09339; HTH_IclR; 1.
DR   Pfam; PF01614; IclR; 1.
DR   SMART; SM00346; HTH_ICLR; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   PROSITE; PS51077; HTH_ICLR; 1.
DR   PROSITE; PS51078; ICLR_ED; 1.
PE   4: Predicted;
KW   Activator; DNA-binding; Glycerol metabolism; Reference proteome;
KW   Transcription; Transcription regulation.
FT   CHAIN           1..254
FT                   /note="Glycerol operon regulatory protein"
FT                   /id="PRO_0000201756"
FT   DOMAIN          5..67
FT                   /note="HTH iclR-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00393"
FT   DOMAIN          82..251
FT                   /note="IclR-ED"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00394"
FT   DNA_BIND        27..46
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00393"
SQ   SEQUENCE   254 AA;  27641 MW;  CF3D076E93536179 CRC64;
     MARNIQSLER AAAMLRLLAG GERRLGLSDI ASSLGLAKGT AHGILRTLQQ EGFVEQDDAS
     GRYQLGAELL RLGTTYLDVH ELRARALVWT DDLARSSGES VHLGVLHQQG VLIVHHVFRP
     DDSRQVLEIG AMQPLHSTAL GKVLSAYDPV AHSEALEADR KAFTDRTVCE PDSFEHVLDI
     TRARGYAADV EETWEGIASI AAPIHDRRRM PVGAVGITGA VERLCREGEL RPELVAAVRD
     CARAVSRDLG AGRF