ID   GYLR_STRGR              Reviewed;         254 AA.
AC   P22866;
DT   01-AUG-1991, integrated into UniProtKB/Swiss-Prot.
DT   01-AUG-1991, sequence version 1.
DT   25-MAY-2022, entry version 75.
DE   RecName: Full=Glycerol operon regulatory protein;
GN   Name=gylR;
OS   Streptomyces griseus.
OC   Bacteria; Actinobacteria; Streptomycetales; Streptomycetaceae;
OC   Streptomyces.
OX   NCBI_TaxID=1911;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=2110096; DOI=10.1016/0378-1119(90)90508-o;
RA   Bolotin A., Biro S.;
RT   "Nucleotide sequence of the putative regulatory gene and major promoter
RT   region of the Streptomyces griseus glycerol operon.";
RL   Gene 87:151-152(1990).
CC   -!- FUNCTION: May be an activator protein for the gylABX operon.
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DR   EMBL; M37327; AAA26750.1; -; mRNA.
DR   PIR; JQ0490; JQ0490.
DR   AlphaFoldDB; P22866; -.
DR   SMR; P22866; -.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0006071; P:glycerol metabolic process; IEA:UniProtKB-KW.
DR   GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:InterPro.
DR   Gene3D; 1.10.10.10; -; 1.
DR   Gene3D; 3.30.450.40; -; 1.
DR   InterPro; IPR029016; GAF-like_dom_sf.
DR   InterPro; IPR014757; Tscrpt_reg_IclR_C.
DR   InterPro; IPR005471; Tscrpt_reg_IclR_N.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   Pfam; PF09339; HTH_IclR; 1.
DR   Pfam; PF01614; IclR; 1.
DR   SMART; SM00346; HTH_ICLR; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   PROSITE; PS51077; HTH_ICLR; 1.
DR   PROSITE; PS51078; ICLR_ED; 1.
PE   2: Evidence at transcript level;
KW   Activator; DNA-binding; Glycerol metabolism; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..254
FT                   /note="Glycerol operon regulatory protein"
FT                   /id="PRO_0000201757"
FT   DOMAIN          5..67
FT                   /note="HTH iclR-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00393"
FT   DOMAIN          82..251
FT                   /note="IclR-ED"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00394"
FT   DNA_BIND        27..46
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00393"
SQ   SEQUENCE   254 AA;  27032 MW;  BAA73DFF3754FBAC CRC64;
     MARNIQSLER AAAMLRLLAG GERRLGLSDI ASTLGLAKGT AHGILRSLQA EGFVEQEPAS
     GRYQLGAELL ALGNSYLDVH ELRARALVWT DDLARSSGEA AYLGVLHQQG VLIVHHVFRP
     DDSRQVLEVG AMHPLHSTAH GKVISAFDPV AHSEVLEGDR ATLTGRTVTE AAAFEEVLDL
     TRARGWALDL EETWEGVASL AAPVHDRRRM AVGAVGVTGP VERLCPDGAP ATELVTAVRD
     CAAAVSRDLG AGRF