ID   GYMN_GYMCH              Reviewed;          10 AA.
AC   P84200;
DT   09-NOV-2004, integrated into UniProtKB/Swiss-Prot.
DT   25-OCT-2004, sequence version 1.
DT   25-MAY-2022, entry version 27.
DE   RecName: Full=Gymnin;
DE   Flags: Fragment;
OS   Gymnocladus chinensis (Soap tree) (Yunnan bean).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   rosids; fabids; Fabales; Fabaceae; Caesalpinioideae; Umtiza clade;
OC   Gymnocladus.
OX   NCBI_TaxID=66097;
RN   [1] {ECO:0000305}
RP   PROTEIN SEQUENCE, AND FUNCTION.
RC   TISSUE=Seed {ECO:0000269|PubMed:14499273};
RX   PubMed=14499273; DOI=10.1016/s0196-9781(03)00192-x;
RA   Wong J.H., Ng T.B.;
RT   "Gymnin, a potent defensin-like antifungal peptide from the Yunnan bean
RT   (Gymnocladus chinensis Baill).";
RL   Peptides 24:963-968(2003).
CC   -!- FUNCTION: Exerts antifungal activity against F.oxysporum and
CC       M.arachidicola, with an IC(50) of 2 uM for the former fungus and 10 uM,
CC       respectively. Has weak mitogenic activity against murine splenocytes.
CC       Displays antiproliferative activity on a human hepatoma cell line and
CC       mouse leukemia cell lines. Inhibits human immunodeficiency virus-1
CC       (HIV-1) reverse transcriptase. {ECO:0000269|PubMed:14499273}.
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DR   GO; GO:0050832; P:defense response to fungus; IEA:UniProtKB-KW.
DR   GO; GO:0031640; P:killing of cells of another organism; IEA:UniProtKB-KW.
PE   1: Evidence at protein level;
KW   Antimicrobial; Direct protein sequencing; Fungicide.
FT   PEPTIDE         1..>10
FT                   /note="Gymnin"
FT                   /id="PRO_0000045099"
FT   NON_TER         10
FT                   /evidence="ECO:0000303|PubMed:14499273"
SQ   SEQUENCE   10 AA;  1171 MW;  94060DADD7244B1E CRC64;
     KTCENLADDY