ID   GYP10_SCHPO             Reviewed;         373 AA.
AC   O94661;
DT   24-JAN-2006, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-1999, sequence version 1.
DT   03-AUG-2022, entry version 111.
DE   RecName: Full=GTPase-activating protein gyp10;
GN   Name=gyp10; ORFNames=SPBC651.03c;
OS   Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC   Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC   Schizosaccharomyces.
OX   NCBI_TaxID=284812;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=972 / ATCC 24843;
RX   PubMed=11859360; DOI=10.1038/nature724;
RA   Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA   Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA   Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA   Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA   Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA   Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA   Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA   Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA   O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA   Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA   Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA   Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA   Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA   Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA   Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA   Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA   Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA   Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA   Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA   Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA   del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA   Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA   Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA   Nurse P.;
RT   "The genome sequence of Schizosaccharomyces pombe.";
RL   Nature 415:871-880(2002).
RN   [2]
RP   FUNCTION, AND SUBCELLULAR LOCATION.
RX   PubMed=16291723; DOI=10.1242/jcs.02664;
RA   Morrell-Falvey J.L., Ren L., Feoktistova A., Haese G.D., Gould K.L.;
RT   "Cell wall remodeling at the fission yeast cell division site requires the
RT   Rho-GEF Rgf3p.";
RL   J. Cell Sci. 118:5563-5573(2005).
RN   [3]
RP   SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
RX   PubMed=16823372; DOI=10.1038/nbt1222;
RA   Matsuyama A., Arai R., Yashiroda Y., Shirai A., Kamata A., Sekido S.,
RA   Kobayashi Y., Hashimoto A., Hamamoto M., Hiraoka Y., Horinouchi S.,
RA   Yoshida M.;
RT   "ORFeome cloning and global analysis of protein localization in the fission
RT   yeast Schizosaccharomyces pombe.";
RL   Nat. Biotechnol. 24:841-847(2006).
CC   -!- FUNCTION: Has a role in vesicular trafficking and septation during
CC       cytokinesis. {ECO:0000269|PubMed:16291723}.
CC   -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC       {ECO:0000269|PubMed:16291723, ECO:0000269|PubMed:16823372}; Single-pass
CC       membrane protein {ECO:0000269|PubMed:16291723,
CC       ECO:0000269|PubMed:16823372}.
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DR   EMBL; CU329671; CAB37599.1; -; Genomic_DNA.
DR   PIR; T40602; T40602.
DR   RefSeq; NP_595501.1; NM_001021411.2.
DR   AlphaFoldDB; O94661; -.
DR   SMR; O94661; -.
DR   BioGRID; 277664; 19.
DR   STRING; 4896.SPBC651.03c.1; -.
DR   iPTMnet; O94661; -.
DR   MaxQB; O94661; -.
DR   PaxDb; O94661; -.
DR   PRIDE; O94661; -.
DR   EnsemblFungi; SPBC651.03c.1; SPBC651.03c.1:pep; SPBC651.03c.
DR   GeneID; 2541149; -.
DR   KEGG; spo:SPBC651.03c; -.
DR   PomBase; SPBC651.03c; gyp10.
DR   VEuPathDB; FungiDB:SPBC651.03c; -.
DR   eggNOG; KOG2595; Eukaryota.
DR   HOGENOM; CLU_039465_0_1_1; -.
DR   InParanoid; O94661; -.
DR   OMA; YPMLCYF; -.
DR   PhylomeDB; O94661; -.
DR   Reactome; R-SPO-204005; COPII-mediated vesicle transport.
DR   PRO; PR:O94661; -.
DR   Proteomes; UP000002485; Chromosome II.
DR   GO; GO:0005829; C:cytosol; HDA:PomBase.
DR   GO; GO:0005783; C:endoplasmic reticulum; IDA:PomBase.
DR   GO; GO:0005789; C:endoplasmic reticulum membrane; IBA:GO_Central.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005634; C:nucleus; HDA:PomBase.
DR   GO; GO:0005096; F:GTPase activator activity; ISM:PomBase.
DR   GO; GO:0006888; P:endoplasmic reticulum to Golgi vesicle-mediated transport; IBA:GO_Central.
DR   GO; GO:0043547; P:positive regulation of GTPase activity; IEA:InterPro.
DR   GO; GO:0035023; P:regulation of Rho protein signal transduction; IGI:PomBase.
DR   GO; GO:0000920; P:septum digestion after cytokinesis; IGI:PomBase.
DR   GO; GO:0016192; P:vesicle-mediated transport; IGI:PomBase.
DR   InterPro; IPR000195; Rab-GTPase-TBC_dom.
DR   InterPro; IPR035969; Rab-GTPase_TBC_sf.
DR   InterPro; IPR045913; TBC20/Gyp8-like.
DR   PANTHER; PTHR20913; PTHR20913; 1.
DR   Pfam; PF00566; RabGAP-TBC; 1.
DR   SMART; SM00164; TBC; 1.
DR   SUPFAM; SSF47923; SSF47923; 2.
DR   PROSITE; PS50086; TBC_RABGAP; 1.
PE   4: Predicted;
KW   Endoplasmic reticulum; GTPase activation; Membrane; Reference proteome;
KW   Transmembrane; Transmembrane helix.
FT   CHAIN           1..373
FT                   /note="GTPase-activating protein gyp10"
FT                   /id="PRO_0000208019"
FT   TRANSMEM        343..363
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   DOMAIN          35..220
FT                   /note="Rab-GAP TBC"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00163"
SQ   SEQUENCE   373 AA;  42549 MW;  866CB2653BF28038 CRC64;
     MKKKEIKQLK NEIKIALLNS DVETLSHIGK EGHGFLMKSL RKSVWVSLCG LSCRHRMECL
     SRSTSQSSYA DQNQVHLDSE RSFFQYKLNP FLLRKHRSQL TKLLSVVFKH YPELCYYQGL
     HDIAQILLLT LPFSHALPLM EHLVFYRLRD FMLPTLDGTV KQLQLILAVI KARDPTLYEY
     LIKADIQCYF ALSWLITWFA HDVSDISVVC RLFDFFISSH PLTVVYTCAQ VVLDNRTSII
     ELLWDNSGAD LLHSYLCKLP ASINVNQLIK NTCATISAVP FSSLPLDRYQ ISPYSCLRNT
     GDPWEYMSRS NGLLLFRLQL AELQEEKHKP GTKVPAVFLQ ENIFNGCNML AAITVIGIGI
     VASQLIPKST SNS