GYP1_SCHPO
ID GYP1_SCHPO Reviewed; 514 AA.
AC O59737;
DT 04-DEC-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-AUG-1998, sequence version 1.
DT 03-AUG-2022, entry version 117.
DE RecName: Full=GTPase-activating protein gyp1;
DE AltName: Full=GAP for ypt1;
GN Name=gyp1 {ECO:0000312|EMBL:CAA19167.1}; ORFNames=SPBC530.01;
OS Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC Schizosaccharomyces.
OX NCBI_TaxID=284812;
RN [1] {ECO:0000312|EMBL:CAA19167.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=972 / ATCC 24843;
RX PubMed=11859360; DOI=10.1038/nature724;
RA Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA Nurse P.;
RT "The genome sequence of Schizosaccharomyces pombe.";
RL Nature 415:871-880(2002).
RN [2] {ECO:0000305}
RP SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
RX PubMed=16823372; DOI=10.1038/nbt1222;
RA Matsuyama A., Arai R., Yashiroda Y., Shirai A., Kamata A., Sekido S.,
RA Kobayashi Y., Hashimoto A., Hamamoto M., Hiraoka Y., Horinouchi S.,
RA Yoshida M.;
RT "ORFeome cloning and global analysis of protein localization in the fission
RT yeast Schizosaccharomyces pombe.";
RL Nat. Biotechnol. 24:841-847(2006).
CC -!- FUNCTION: Stimulates specifically the GTPase activity of ypt1.
CC Functions on the Golgi as a negative regulator of ypt1 (By similarity).
CC {ECO:0000250|UniProtKB:Q08484}.
CC -!- SUBCELLULAR LOCATION: Golgi apparatus, Golgi stack
CC {ECO:0000250|UniProtKB:Q08484}. Cytoplasm
CC {ECO:0000269|PubMed:16823372}. Nucleus {ECO:0000269|PubMed:16823372}.
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DR EMBL; CU329671; CAA19167.1; -; Genomic_DNA.
DR PIR; T40517; T40517.
DR RefSeq; NP_595314.1; NM_001021221.2.
DR AlphaFoldDB; O59737; -.
DR SMR; O59737; -.
DR BioGRID; 277408; 67.
DR STRING; 4896.SPBC530.01.1; -.
DR iPTMnet; O59737; -.
DR MaxQB; O59737; -.
DR PaxDb; O59737; -.
DR PRIDE; O59737; -.
DR EnsemblFungi; SPBC530.01.1; SPBC530.01.1:pep; SPBC530.01.
DR GeneID; 2540892; -.
DR KEGG; spo:SPBC530.01; -.
DR PomBase; SPBC530.01; gyp1.
DR VEuPathDB; FungiDB:SPBC530.01; -.
DR eggNOG; KOG1092; Eukaryota.
DR HOGENOM; CLU_018687_4_1_1; -.
DR InParanoid; O59737; -.
DR OMA; YVCAVFL; -.
DR PhylomeDB; O59737; -.
DR PRO; PR:O59737; -.
DR Proteomes; UP000002485; Chromosome II.
DR GO; GO:0005737; C:cytoplasm; HDA:PomBase.
DR GO; GO:0005829; C:cytosol; HDA:PomBase.
DR GO; GO:0005794; C:Golgi apparatus; IBA:GO_Central.
DR GO; GO:0005795; C:Golgi stack; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; HDA:PomBase.
DR GO; GO:0005096; F:GTPase activator activity; ISM:PomBase.
DR GO; GO:0090630; P:activation of GTPase activity; IBA:GO_Central.
DR GO; GO:0016192; P:vesicle-mediated transport; NAS:PomBase.
DR InterPro; IPR000195; Rab-GTPase-TBC_dom.
DR InterPro; IPR035969; Rab-GTPase_TBC_sf.
DR Pfam; PF00566; RabGAP-TBC; 1.
DR SMART; SM00164; TBC; 1.
DR SUPFAM; SSF47923; SSF47923; 2.
DR PROSITE; PS50086; TBC_RABGAP; 1.
PE 3: Inferred from homology;
KW Cytoplasm; Golgi apparatus; GTPase activation; Nucleus; Reference proteome.
FT CHAIN 1..514
FT /note="GTPase-activating protein gyp1"
FT /id="PRO_0000312835"
FT DOMAIN 216..443
FT /note="Rab-GAP TBC"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00163"
FT REGION 17..65
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 130..164
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 17..31
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 130..163
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 514 AA; 58449 MW; 3F606E688085AA91 CRC64;
MESQSKKSSA LKTLSSLWNG SSSATSDPVT VLDRSRTHHH RGRSTSSKAQ PFRLDDSVYS
DQPPKDHISL ARSITRPESA SESKIYAPSA RSSLSLEAVV GKKVSAKFAK YLSQTDDDWG
VSNIKASKSL PRMARSTTPN SSSRSLFPQN GVDTTTSRQK LHSSGRFPLP AKLAHRSVEV
EVAESNALVS RIKKFSRILD APIVDLNALR TLAWNGIPSE HRPIVWKYLL GYLPCNASRR
EVTLKRKRDE YNAAKDSCFN TNTEPPPLDQ TIWRQIVLDV PRTNPSILLY QNPLTQRMLE
RILYVWASRH PASGYVQGIS DLVTPFIQVF LSEYIGDKDP MTYDIALLDE TNRNDIEADA
YWCLSKLLDG IQDNYIHAQP GIRRQVNNLR ELTLRIDEPL VKHLQMEGVD FLQFSFRWMN
CLLMRELSIS NIIRMWDTYM AEGVQGFSEF HLYVCAAFLV KWSSELQKME FQDILIFLQS
IPTKDWSTKD IEILLSEAFL WKSLYSGAGA HLKR
