ID   GYP2_EMENI              Reviewed;        1120 AA.
AC   C8VDQ4; Q5AV96;
DT   05-APR-2011, integrated into UniProtKB/Swiss-Prot.
DT   03-NOV-2009, sequence version 1.
DT   25-MAY-2022, entry version 69.
DE   RecName: Full=Putative GTPase-activating protein AN11010;
GN   ORFNames=AN11010, AN7784;
OS   Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 /
OS   M139) (Aspergillus nidulans).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC   Aspergillus subgen. Nidulantes.
OX   NCBI_TaxID=227321;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139;
RX   PubMed=16372000; DOI=10.1038/nature04341;
RA   Galagan J.E., Calvo S.E., Cuomo C., Ma L.-J., Wortman J.R., Batzoglou S.,
RA   Lee S.-I., Bastuerkmen M., Spevak C.C., Clutterbuck J., Kapitonov V.,
RA   Jurka J., Scazzocchio C., Farman M.L., Butler J., Purcell S., Harris S.,
RA   Braus G.H., Draht O., Busch S., D'Enfert C., Bouchier C., Goldman G.H.,
RA   Bell-Pedersen D., Griffiths-Jones S., Doonan J.H., Yu J., Vienken K.,
RA   Pain A., Freitag M., Selker E.U., Archer D.B., Penalva M.A., Oakley B.R.,
RA   Momany M., Tanaka T., Kumagai T., Asai K., Machida M., Nierman W.C.,
RA   Denning D.W., Caddick M.X., Hynes M., Paoletti M., Fischer R., Miller B.L.,
RA   Dyer P.S., Sachs M.S., Osmani S.A., Birren B.W.;
RT   "Sequencing of Aspergillus nidulans and comparative analysis with A.
RT   fumigatus and A. oryzae.";
RL   Nature 438:1105-1115(2005).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139;
RX   PubMed=19146970; DOI=10.1016/j.fgb.2008.12.003;
RA   Wortman J.R., Gilsenan J.M., Joardar V., Deegan J., Clutterbuck J.,
RA   Andersen M.R., Archer D., Bencina M., Braus G., Coutinho P., von Dohren H.,
RA   Doonan J., Driessen A.J., Durek P., Espeso E., Fekete E., Flipphi M.,
RA   Estrada C.G., Geysens S., Goldman G., de Groot P.W., Hansen K.,
RA   Harris S.D., Heinekamp T., Helmstaedt K., Henrissat B., Hofmann G.,
RA   Homan T., Horio T., Horiuchi H., James S., Jones M., Karaffa L.,
RA   Karanyi Z., Kato M., Keller N., Kelly D.E., Kiel J.A., Kim J.M.,
RA   van der Klei I.J., Klis F.M., Kovalchuk A., Krasevec N., Kubicek C.P.,
RA   Liu B., Maccabe A., Meyer V., Mirabito P., Miskei M., Mos M., Mullins J.,
RA   Nelson D.R., Nielsen J., Oakley B.R., Osmani S.A., Pakula T., Paszewski A.,
RA   Paulsen I., Pilsyk S., Pocsi I., Punt P.J., Ram A.F., Ren Q., Robellet X.,
RA   Robson G., Seiboth B., van Solingen P., Specht T., Sun J.,
RA   Taheri-Talesh N., Takeshita N., Ussery D., vanKuyk P.A., Visser H.,
RA   van de Vondervoort P.J., de Vries R.P., Walton J., Xiang X., Xiong Y.,
RA   Zeng A.P., Brandt B.W., Cornell M.J., van den Hondel C.A., Visser J.,
RA   Oliver S.G., Turner G.;
RT   "The 2008 update of the Aspergillus nidulans genome annotation: a community
RT   effort.";
RL   Fungal Genet. Biol. 46:S2-13(2009).
CC   -!- SEQUENCE CAUTION:
CC       Sequence=EAA61572.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR   EMBL; AACD01000132; EAA61572.1; ALT_SEQ; Genomic_DNA.
DR   EMBL; BN001304; CBF80101.1; -; Genomic_DNA.
DR   RefSeq; XP_681053.1; XM_675961.1.
DR   AlphaFoldDB; C8VDQ4; -.
DR   SMR; C8VDQ4; -.
DR   STRING; 162425.CADANIAP00000923; -.
DR   PRIDE; C8VDQ4; -.
DR   EnsemblFungi; CBF80101; CBF80101; ANIA_11010.
DR   EnsemblFungi; EAA61572; EAA61572; AN7784.2.
DR   GeneID; 2869693; -.
DR   KEGG; ani:AN7784.2; -.
DR   VEuPathDB; FungiDB:AN11010; -.
DR   eggNOG; KOG4347; Eukaryota.
DR   HOGENOM; CLU_003538_1_0_1; -.
DR   InParanoid; C8VDQ4; -.
DR   OMA; LTAYSWI; -.
DR   OrthoDB; 450360at2759; -.
DR   Proteomes; UP000000560; Chromosome IV.
DR   Proteomes; UP000005890; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IEA:EnsemblFungi.
DR   GO; GO:0005096; F:GTPase activator activity; IBA:GO_Central.
DR   GO; GO:0090630; P:activation of GTPase activity; IBA:GO_Central.
DR   InterPro; IPR011992; EF-hand-dom_pair.
DR   InterPro; IPR000195; Rab-GTPase-TBC_dom.
DR   InterPro; IPR035969; Rab-GTPase_TBC_sf.
DR   Pfam; PF00566; RabGAP-TBC; 1.
DR   SMART; SM00164; TBC; 1.
DR   SUPFAM; SSF47473; SSF47473; 1.
DR   SUPFAM; SSF47923; SSF47923; 2.
DR   PROSITE; PS50086; TBC_RABGAP; 1.
PE   4: Predicted;
KW   Reference proteome.
FT   CHAIN           1..1120
FT                   /note="Putative GTPase-activating protein AN11010"
FT                   /id="PRO_0000406151"
FT   DOMAIN          291..479
FT                   /note="Rab-GAP TBC"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00163"
FT   REGION          673..702
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          859..903
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          960..979
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1017..1068
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1081..1120
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1081..1097
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1120 AA;  124986 MW;  8EDF8367ABA0D413 CRC64;
     MMQWTSLVQK AQSFIDPANF TIPNLTSSSD RNPSKSSLFR QQFRLPDSQN PLQEITAELI
     LPVSHTSSSA SGAQSKNIDR GGNRYAGRLH LSERFLCFST QPTSFLPSAT LATSTYWAGQ
     TNGTGPSGNG FTIPLCSIRR VERLNSQSHI FSLALTTWNG ALGKQQAPGF TPQRFTIELV
     GSRQACERFC DGLKKNLRES MKEIENLRLV VNDCYSEYLL SGAKSKAQSA DDPEARPPPD
     AGLGMLFRYP GDARKLRDRS KMRLWGEYFR ENGRNATLIR QPTFHKLIRV GLPNRLRGEI
     WEVASGSLNL RLRSPKLYEQ TLAKFEGQES LAIDEIEKDL NRSLPEYAGF QSEEGIGRLR
     RVLTAYSWTN AEIGYCQAMN IVVAALLIYM SEAQAFFLLS VLCDRLVPGY YSTTMYGTLL
     DQKVFESLVE KTMPILWDHL NKSDVQLSVV SLPWFLSLYI NSMPLVFAFR VLDVFFLEGP
     KVLFQVGLAI LRINGEELLD VQDDGSFISV LKSYFSRLDE SAHPRSENPK LRAITRFQEL
     MVVAFKEFSQ ITHQTITEQR EKHKDAVLEN IESFAKRTSI RNLGPESKKL SSDDLGAIYD
     RYYEVLYDYQ QRQKVIEEEK KRQERKKSQR VSVIGPSVDR EVGRVGLGPS PTHMDYNAFR
     EFLAATAKWA IADSPGPSRK QSDSGSFRGL GRPTMNKRPS PADHEFMQRL FRKWSTDPDD
     GLSLQDVVNG IARLKGPRDI MNNITYFFDL YDDNGDGKVD REGILRMSEA LLFLSRRGFD
     GTITPSQSTE NLMPGKEEDK LSTGERFLGS VSSFIRRCFE YADPTKKTLE AEKLAETTDN
     LNSFSIGDDE EDLIDVGDDE VKSESTPSPE GETPGTPSLE PTERKRARST SEAANPALDP
     NNPLHITLPT FRMVVLADEL LEQFFDNYFP QSFHLSEQGA AAAQLPSLSS NLTTFSNIGA
     AKQQPTSSGP TVAGASGGIV PPNRGLRGVL DNIVTDGIRM AAEVKKRMDE AQRELERNAL
     NRDDDDEDDE DDDGHHGTAP AIVGGISSWG AGAYGADPER RSVRETDRDL LEGAEVVNIR
     GKDDVSLLDD KDSHQESSSG QRTAAGSDDK VVSKVVEFES