ID   GYP2_SCHPO              Reviewed;         720 AA.
AC   O94711;
DT   04-DEC-2007, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-1999, sequence version 1.
DT   25-MAY-2022, entry version 113.
DE   RecName: Full=GTPase-activating protein gyp2;
GN   Name=gyp2 {ECO:0000312|EMBL:CAA22549.1}; ORFNames=SPCC1259.11c;
OS   Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC   Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC   Schizosaccharomyces.
OX   NCBI_TaxID=284812;
RN   [1] {ECO:0000312|EMBL:CAA22549.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=972 / ATCC 24843;
RX   PubMed=11859360; DOI=10.1038/nature724;
RA   Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA   Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA   Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA   Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA   Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA   Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA   Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA   Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA   O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA   Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA   Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA   Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA   Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA   Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA   Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA   Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA   Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA   Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA   Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA   Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA   del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA   Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA   Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA   Nurse P.;
RT   "The genome sequence of Schizosaccharomyces pombe.";
RL   Nature 415:871-880(2002).
RN   [2] {ECO:0000305}
RP   SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
RX   PubMed=16823372; DOI=10.1038/nbt1222;
RA   Matsuyama A., Arai R., Yashiroda Y., Shirai A., Kamata A., Sekido S.,
RA   Kobayashi Y., Hashimoto A., Hamamoto M., Hiraoka Y., Horinouchi S.,
RA   Yoshida M.;
RT   "ORFeome cloning and global analysis of protein localization in the fission
RT   yeast Schizosaccharomyces pombe.";
RL   Nat. Biotechnol. 24:841-847(2006).
CC   -!- FUNCTION: Stimulates specifically the GTPase activity of ypt2 and ryh1.
CC       Inactivates ryh1 during recycling between the endosome and the Golgi
CC       compartments (By similarity). {ECO:0000250|UniProtKB:P53258}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:16823372}. Nucleus
CC       {ECO:0000269|PubMed:16823372}.
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DR   EMBL; CU329672; CAA22549.1; -; Genomic_DNA.
DR   PIR; T40900; T40900.
DR   RefSeq; NP_588067.1; NM_001023059.2.
DR   AlphaFoldDB; O94711; -.
DR   SMR; O94711; -.
DR   BioGRID; 275712; 4.
DR   STRING; 4896.SPCC1259.11c.1; -.
DR   MaxQB; O94711; -.
DR   PaxDb; O94711; -.
DR   EnsemblFungi; SPCC1259.11c.1; SPCC1259.11c.1:pep; SPCC1259.11c.
DR   GeneID; 2539140; -.
DR   KEGG; spo:SPCC1259.11c; -.
DR   PomBase; SPCC1259.11c; gyp2.
DR   VEuPathDB; FungiDB:SPCC1259.11c; -.
DR   eggNOG; KOG4347; Eukaryota.
DR   HOGENOM; CLU_003538_0_1_1; -.
DR   InParanoid; O94711; -.
DR   OMA; QAYFLFS; -.
DR   PhylomeDB; O94711; -.
DR   PRO; PR:O94711; -.
DR   Proteomes; UP000002485; Chromosome III.
DR   GO; GO:0005829; C:cytosol; HDA:PomBase.
DR   GO; GO:0005634; C:nucleus; HDA:PomBase.
DR   GO; GO:0005096; F:GTPase activator activity; ISM:PomBase.
DR   GO; GO:0090630; P:activation of GTPase activity; IBA:GO_Central.
DR   GO; GO:0016192; P:vesicle-mediated transport; NAS:PomBase.
DR   Gene3D; 2.30.29.30; -; 1.
DR   InterPro; IPR011992; EF-hand-dom_pair.
DR   InterPro; IPR004182; GRAM.
DR   InterPro; IPR011993; PH-like_dom_sf.
DR   InterPro; IPR000195; Rab-GTPase-TBC_dom.
DR   InterPro; IPR035969; Rab-GTPase_TBC_sf.
DR   Pfam; PF02893; GRAM; 1.
DR   Pfam; PF00566; RabGAP-TBC; 1.
DR   SMART; SM00568; GRAM; 1.
DR   SMART; SM00164; TBC; 1.
DR   SUPFAM; SSF47473; SSF47473; 1.
DR   SUPFAM; SSF47923; SSF47923; 2.
DR   PROSITE; PS50086; TBC_RABGAP; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; GTPase activation; Nucleus; Reference proteome.
FT   CHAIN           1..720
FT                   /note="GTPase-activating protein gyp2"
FT                   /id="PRO_0000312836"
FT   DOMAIN          20..85
FT                   /note="GRAM"
FT                   /evidence="ECO:0000255"
FT   DOMAIN          216..404
FT                   /note="Rab-GAP TBC"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00163"
SQ   SEQUENCE   720 AA;  82749 MW;  7CFF5D45AB1E3BE4 CRC64;
     MNLLKHIFLE DDYDAYEGTL DPASFFRINK QEEIIASTVC EIGWEYSKSF GNAYICTSFL
     CFHSDDFKTR FTFPLAAVRK LERENSDNDT FTFDLSNFHS QIIHLRFKGT RQQSEFFCDR
     LVRQLHASLE DASSVGLFLL SLASERVCFS ESANSQEIES IDLGLGSQFG YPIASSNTNG
     LINENNSKSW IQYLKKNGAN FNLIQTPNFQ KLVQSGIPNN LRADIWETCS GSLFPRWKSK
     GFYAKNIDSV INNRCEYSEE IEKDLTRSLP DYPAYQSPTG INTLRRILLF YSETNKEVGY
     CQAMNIVLAA LLVYCTEEQA YFLFSQLCEF YIPGYYAKII HGLLLDLTVF EYVLEHTLPH
     LYQKIIELDM DLKLITINWF FSLFIKDFRL DYAFRILDCL FVNGPRVLFQ VALALFKVNA
     QGILNATDDS SVMKVFRQCF DHINQGTAAD EKMAALGSRS SMCTLPQLFA VAFEYFDFIT
     DSFVSAKRKE FKSSVLYSLR CFTKRSHLRS VYQTTLLSNT DLDLVYDAFI NAIGENNICH
     GDVLEQKIDF NGFERLVDCA APPLSVIREP LHYQRSKRKL FTRLYIWMKD GDSTETSLTF
     KRIIHGLERL KADIALHSEI LCFQLYDLKR DGTLRTEEVV ELSESLILLC CYEGDEKDEE
     RLTVISEFLK SCFSGCQDRR SFQITMEDFQ AIVDTTGLHA TLEFFLKKLI DGLLGKLNAS