ID   GYP7_CANGA              Reviewed;         745 AA.
AC   Q6FWI1;
DT   11-OCT-2004, integrated into UniProtKB/Swiss-Prot.
DT   19-JUL-2004, sequence version 1.
DT   25-MAY-2022, entry version 79.
DE   RecName: Full=GTPase-activating protein GYP7;
DE   AltName: Full=GAP for YPT7;
GN   Name=GYP7; OrderedLocusNames=CAGL0C05489g;
OS   Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL
OS   Y-65) (Yeast) (Torulopsis glabrata).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Nakaseomyces;
OC   Nakaseomyces/Candida clade.
OX   NCBI_TaxID=284593;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65;
RX   PubMed=15229592; DOI=10.1038/nature02579;
RA   Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA   de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA   Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA   Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA   Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA   Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA   Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA   Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S.,
RA   Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F.,
RA   Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M.,
RA   Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M.,
RA   Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C.,
RA   Weissenbach J., Wincker P., Souciet J.-L.;
RT   "Genome evolution in yeasts.";
RL   Nature 430:35-44(2004).
CC   -!- FUNCTION: Most effectively accelerate the intrinsic GTPase activity of
CC       YPT7. It is also active, but to a lesser extent, on YPT31, YPT32 and
CC       YPT1. YPT6 and SEC4 (By similarity). {ECO:0000250}.
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DR   EMBL; CR380949; CAG58319.1; -; Genomic_DNA.
DR   RefSeq; XP_445413.1; XM_445413.1.
DR   AlphaFoldDB; Q6FWI1; -.
DR   SMR; Q6FWI1; -.
DR   STRING; 5478.XP_445413.1; -.
DR   EnsemblFungi; CAG58319; CAG58319; CAGL0C05489g.
DR   GeneID; 2886868; -.
DR   KEGG; cgr:CAGL0C05489g; -.
DR   CGD; CAL0127226; CAGL0C05489g.
DR   VEuPathDB; FungiDB:CAGL0C05489g; -.
DR   eggNOG; KOG2197; Eukaryota.
DR   HOGENOM; CLU_004457_0_1_1; -.
DR   InParanoid; Q6FWI1; -.
DR   OMA; ERNQRIW; -.
DR   Proteomes; UP000002428; Chromosome C.
DR   GO; GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW.
DR   GO; GO:0032889; P:regulation of vacuole fusion, non-autophagic; IEA:EnsemblFungi.
DR   GO; GO:0016192; P:vesicle-mediated transport; IEA:EnsemblFungi.
DR   InterPro; IPR000195; Rab-GTPase-TBC_dom.
DR   InterPro; IPR035969; Rab-GTPase_TBC_sf.
DR   Pfam; PF00566; RabGAP-TBC; 1.
DR   SMART; SM00164; TBC; 1.
DR   SUPFAM; SSF47923; SSF47923; 2.
DR   PROSITE; PS50086; TBC_RABGAP; 1.
PE   3: Inferred from homology;
KW   GTPase activation; Reference proteome.
FT   CHAIN           1..745
FT                   /note="GTPase-activating protein GYP7"
FT                   /id="PRO_0000208014"
FT   DOMAIN          391..623
FT                   /note="Rab-GAP TBC"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00163"
SQ   SEQUENCE   745 AA;  87415 MW;  24DF9E4F281BDDB0 CRC64;
     MSIELLFCKS QVYIHPTKNL QDNVSGYLLI THQSNSETIT SSTISWIPEN SLNEEDINFL
     NNAETRNINE KILRLPVSSR KLNTLLGSGS FLSSNWQFTI PVLSLYSVQF KLPNTWWYGS
     CILYSKSPRE TESIPVLYFH DDLCPSTISK QKELNRSFDP FNNSNEMYWG GQDFKDALGS
     IVELKRVESE PTFWLVNATL EDLRNFSSAN LKSSEEKPSS SKDDGVTKLK EDAWQKWEST
     KWSLMSQFAD ITAKTGSFVG SLIKKHPVVQ LVERNKNNYY VQKMLKNPKV VEIQDDFDSA
     KIYLAKWALS VKEEAERYQE GSYDNPYRRI LVSEFGLTGN EDVSFTEEEL NRAMERNHPM
     TKQKWNSLFD SEGRLTVTVN EVKDYIFHGG LADDATRKEV WPFLLGVYPW DSSEDERKQL
     RKALHDEYME LKQKWVDREV NLDNDEEEYW KDQLFRIEKD VKRNDRNIDI YKYNTSDNLP
     FPEDTAPTTD DDDSIKNPNL KKLADILTTY NIFNPNLGYV QGMTDLLSPL YYIIRDEETT
     FWCFTNFMER MERNFLRDQS GIRDQMLALT DLCQLMLPRL SAHLQKCDSS DLFFCFRMLL
     VWFKREFNYD DIFNIWEVFF TDFYSSQYQL FFMLAILQKN SSPIVNNLQT FDQVIKYFND
     LNSKMNWRDL MVRSELLFIQ FHKTADLLAR RQEQLIPENS GHDTSDIEGG TEPKTQSYIS
     EHLQTLLSKE VIIQKENTRT KDSIK