ID   GYP7_DEBHA              Reviewed;         757 AA.
AC   Q6BU76;
DT   11-OCT-2004, integrated into UniProtKB/Swiss-Prot.
DT   16-DEC-2008, sequence version 2.
DT   25-MAY-2022, entry version 79.
DE   RecName: Full=GTPase-activating protein GYP7;
DE   AltName: Full=GAP for YPT7;
GN   Name=GYP7; OrderedLocusNames=DEHA2C13046g;
OS   Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / BCRC 21394 / JCM 1990
OS   / NBRC 0083 / IGC 2968) (Yeast) (Torulaspora hansenii).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Debaryomycetaceae; Debaryomyces.
OX   NCBI_TaxID=284592;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 36239 / CBS 767 / BCRC 21394 / JCM 1990 / NBRC 0083 / IGC 2968;
RX   PubMed=15229592; DOI=10.1038/nature02579;
RA   Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA   de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA   Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA   Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA   Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA   Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA   Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA   Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S.,
RA   Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F.,
RA   Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M.,
RA   Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M.,
RA   Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C.,
RA   Weissenbach J., Wincker P., Souciet J.-L.;
RT   "Genome evolution in yeasts.";
RL   Nature 430:35-44(2004).
CC   -!- FUNCTION: Most effectively accelerate the intrinsic GTPase activity of
CC       YPT7. It is also active, but to a lesser extent, on YPT31, YPT32 and
CC       YPT1. YPT6 and SEC4 (By similarity). {ECO:0000250}.
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DR   EMBL; CR382135; CAG86319.2; -; Genomic_DNA.
DR   RefSeq; XP_458243.2; XM_458243.1.
DR   AlphaFoldDB; Q6BU76; -.
DR   SMR; Q6BU76; -.
DR   STRING; 4959.XP_458243.2; -.
DR   EnsemblFungi; CAG86319; CAG86319; DEHA2C13046g.
DR   GeneID; 2900078; -.
DR   KEGG; dha:DEHA2C13046g; -.
DR   VEuPathDB; FungiDB:DEHA2C13046g; -.
DR   eggNOG; KOG2197; Eukaryota.
DR   HOGENOM; CLU_004457_0_1_1; -.
DR   InParanoid; Q6BU76; -.
DR   OMA; ERNQRIW; -.
DR   OrthoDB; 1495285at2759; -.
DR   Proteomes; UP000000599; Chromosome C.
DR   GO; GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW.
DR   InterPro; IPR000195; Rab-GTPase-TBC_dom.
DR   InterPro; IPR035969; Rab-GTPase_TBC_sf.
DR   Pfam; PF00566; RabGAP-TBC; 1.
DR   SMART; SM00164; TBC; 1.
DR   SUPFAM; SSF47923; SSF47923; 2.
DR   PROSITE; PS50086; TBC_RABGAP; 1.
PE   3: Inferred from homology;
KW   GTPase activation; Reference proteome.
FT   CHAIN           1..757
FT                   /note="GTPase-activating protein GYP7"
FT                   /id="PRO_0000208015"
FT   DOMAIN          395..640
FT                   /note="Rab-GAP TBC"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00163"
FT   REGION          482..507
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   757 AA;  87694 MW;  C571F0684217E6D3 CRC64;
     MPVDKQAKRK KSISSNEVEL LYTKSKTYLH PTTSKKDNIP GYLSLSRGAN AANRDIIISF
     MSEKQLSSEE LKAYENVDIA DLQDDLEALK LGGTNSRSSG KRNLNIVSKP PTSSAFGFCF
     SIPISFVYSI QVRKPSVGWW FGSIIINTQD GEKLPIVFFH DDESPSTLKN QKVRNQRFDP
     FGDNGEMYWG GSDFMNALGK FADVQKSSVE PSVYLINPES NDLRNFAPFK EPKTAKTETN
     QEPFKLPDVN KFFANAKWKV LETVATFSAK TRNQVLDLVD ENAPMPIKQI INKPEVQKIG
     NEFDSARVYL AKWAAQVKEE AEEAHRKYQL DDEIYNKINK ELGVGSNTEI LTDEEVSKTS
     RRKPISKVEW EGLFDFSGRL IISIDEIKDR IFHGGLEDCI RGEAWLFLLN VYPWDSSAEE
     RKTLRNSFQT AYEEIKLKWV NDDDKRSVDF WKDQKHRIEK DINRTDRNLS IFQNKKKISI
     SGVGSDRLPT TRESSPETPD EADDDEFDVS NITNPHLFKM REILLTYNEH NVNLGYVQGM
     TDLLSPLYVT FQDESLTFWA FVNFMDRMER NFLRDQSGMK NQMLTLNELV QFMLPDLFKH
     LEKCESTDLY FFFRMLLVWF KREFEWSSVL SLWEILWTDY YSGQFHLFFA LAVLSDNERI
     IRQNLSRFDE VLKYMNDLSM NMNLNHLLIR AELLFLRFRR MIDIIDRENS LKKLNNPGVY
     DDANNSLIKI SPALRELLSK KPVIQKETER PEGVGGG