GYP7_SCHPO
ID GYP7_SCHPO Reviewed; 743 AA.
AC Q9UUH7;
DT 04-DEC-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-2000, sequence version 1.
DT 03-AUG-2022, entry version 110.
DE RecName: Full=GTPase-activating protein gyp7;
DE AltName: Full=GAP for ypt7;
GN Name=gyp7 {ECO:0000312|EMBL:CAB52727.1}; ORFNames=SPAC630.05;
OS Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC Schizosaccharomyces.
OX NCBI_TaxID=284812;
RN [1] {ECO:0000312|EMBL:CAB52727.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=972 / ATCC 24843;
RX PubMed=11859360; DOI=10.1038/nature724;
RA Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA Nurse P.;
RT "The genome sequence of Schizosaccharomyces pombe.";
RL Nature 415:871-880(2002).
RN [2] {ECO:0000305}
RP SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
RX PubMed=16823372; DOI=10.1038/nbt1222;
RA Matsuyama A., Arai R., Yashiroda Y., Shirai A., Kamata A., Sekido S.,
RA Kobayashi Y., Hashimoto A., Hamamoto M., Hiraoka Y., Horinouchi S.,
RA Yoshida M.;
RT "ORFeome cloning and global analysis of protein localization in the fission
RT yeast Schizosaccharomyces pombe.";
RL Nat. Biotechnol. 24:841-847(2006).
CC -!- FUNCTION: Most effectively accelerates the intrinsic GTPase activity of
CC ypt7. {ECO:0000250|UniProtKB:P48365}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:16823372}. Nucleus
CC {ECO:0000269|PubMed:16823372}.
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DR EMBL; CU329670; CAB52727.1; -; Genomic_DNA.
DR PIR; T38983; T38983.
DR RefSeq; NP_592900.1; NM_001018300.2.
DR AlphaFoldDB; Q9UUH7; -.
DR SMR; Q9UUH7; -.
DR BioGRID; 280023; 11.
DR STRING; 4896.SPAC630.05.1; -.
DR iPTMnet; Q9UUH7; -.
DR MaxQB; Q9UUH7; -.
DR PaxDb; Q9UUH7; -.
DR PRIDE; Q9UUH7; -.
DR EnsemblFungi; SPAC630.05.1; SPAC630.05.1:pep; SPAC630.05.
DR GeneID; 2543609; -.
DR KEGG; spo:SPAC630.05; -.
DR PomBase; SPAC630.05; gyp7.
DR VEuPathDB; FungiDB:SPAC630.05; -.
DR eggNOG; KOG2197; Eukaryota.
DR HOGENOM; CLU_004457_0_1_1; -.
DR InParanoid; Q9UUH7; -.
DR OMA; ERNQRIW; -.
DR PhylomeDB; Q9UUH7; -.
DR Reactome; R-SPO-8854214; TBC/RABGAPs.
DR PRO; PR:Q9UUH7; -.
DR Proteomes; UP000002485; Chromosome I.
DR GO; GO:0005829; C:cytosol; HDA:PomBase.
DR GO; GO:0005634; C:nucleus; HDA:PomBase.
DR GO; GO:0005096; F:GTPase activator activity; ISM:PomBase.
DR GO; GO:0090630; P:activation of GTPase activity; IBA:GO_Central.
DR GO; GO:0016192; P:vesicle-mediated transport; ISO:PomBase.
DR InterPro; IPR000195; Rab-GTPase-TBC_dom.
DR InterPro; IPR035969; Rab-GTPase_TBC_sf.
DR InterPro; IPR021935; SGSM1/2_RBD.
DR Pfam; PF12068; PH_RBD; 1.
DR Pfam; PF00566; RabGAP-TBC; 1.
DR SMART; SM00164; TBC; 1.
DR SUPFAM; SSF47923; SSF47923; 2.
DR PROSITE; PS50086; TBC_RABGAP; 1.
PE 3: Inferred from homology;
KW Cytoplasm; GTPase activation; Nucleus; Reference proteome.
FT CHAIN 1..743
FT /note="GTPase-activating protein gyp7"
FT /id="PRO_0000312838"
FT DOMAIN 411..633
FT /note="Rab-GAP TBC"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00163"
SQ SEQUENCE 743 AA; 86793 MW; FA209B1303275DE3 CRC64;
MTTLESLDMP EMTEVEDDTV DIHIDNSKVA LLFSKSKVFV HPTSKMKDNI SGYLSLSKSK
ALGNSSVAGS DILLSWVPDS FLKNRPRDLS VFQNAETLSN GSIREWVEIP QHLDYSFSVR
LCSIYSIIFR PPRYGWNYGS IVINLRDSGE SLPPLFFHDD ECISTIEYGK QITRDRFDPF
DESGNMFWGG THLLMQLKKY ASLEQSSHES QLYLVNPSPE DTVAFQSVEL QKVISNNRLN
SSSTPPTPRS SSSIFNPFRR ALHDLSFTVL ERFSRVTNYG KSEVDRLMEH KVTKSILPHL
PRELQVLLES KRVQKLTEEY DPARMFLARW AEGIVEQSES NNSQPVNNAG VWTDAQREED
SSLGPFELVY IEERVKRDDP LSVEQWNSMF NAHGKLQVDV HRVLGIIFHG GIQPSLRKEV
WPFLLSVYPW DSTSEERRVI YLSLQEEYCT LKRKWYEDIH KQFNDRWFIE QRNRIEKDVH
RTDRQHEYFQ IEDLPHPDPQ STFTGTNMNM EMMKDILLTY NEYDTELGYV QGMSDLLAPI
YVTFNDNALT FWGMVGLMKR LHFNFLRDQS GMHRQLDTLR LLIEFMDPEL FAHLEKTDSS
NLFCFFRMLL IYFKREFDWE VLLKLWDVLF TNYLSYDYHI FVAYAIAERH REVLLNQTSA
FDEVLKYFNE LSGKLALEPT LICAEQCFYQ FKNKLALIDR KQMEETNSDE DGSKETDLPT
IAPYLRNLLK TSQPQYTPSG KQE
