ID   GYP7_YARLI              Reviewed;         730 AA.
AC   P09379; O14440; Q6BZP9;
DT   01-JUL-1989, integrated into UniProtKB/Swiss-Prot.
DT   11-OCT-2004, sequence version 2.
DT   03-AUG-2022, entry version 106.
DE   RecName: Full=GTPase-activating protein GYP7;
DE   AltName: Full=GAP for YPT7;
GN   Name=GYP7; OrderedLocusNames=YALI0F31911g;
OS   Yarrowia lipolytica (strain CLIB 122 / E 150) (Yeast) (Candida lipolytica).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Dipodascaceae; Yarrowia.
OX   NCBI_TaxID=284591;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=ATCC MYA-165 / 12-K335;
RX   PubMed=10091609; DOI=10.1046/j.1432-1327.1999.00192.x;
RA   Vollmer P., Will E., Scheglmann D., Strom M., Gallwitz D.;
RT   "Primary structure and biochemical characterization of yeast GTPase-
RT   activating proteins with substrate preference for the transport GTPase
RT   Ypt7p.";
RL   Eur. J. Biochem. 260:284-290(1999).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CLIB 122 / E 150;
RX   PubMed=15229592; DOI=10.1038/nature02579;
RA   Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA   de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA   Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA   Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA   Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA   Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA   Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA   Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S.,
RA   Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F.,
RA   Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M.,
RA   Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M.,
RA   Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C.,
RA   Weissenbach J., Wincker P., Souciet J.-L.;
RT   "Genome evolution in yeasts.";
RL   Nature 430:35-44(2004).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 420-730.
RX   PubMed=2443483; DOI=10.1128/jb.169.10.4621-4629.1987;
RA   Davidow L.S., O'Donnell M.M., Kaczmarek F.S., Pereira D.A., Dezeeuw J.R.,
RA   Franke A.E.;
RT   "Cloning and sequencing of the alkaline extracellular protease gene of
RT   Yarrowia lipolytica.";
RL   J. Bacteriol. 169:4621-4629(1987).
CC   -!- FUNCTION: Most effectively accelerate the intrinsic GTPase activity of
CC       YPT7. It is also active, but to a lesser extent, on YPT31, YPT32 and
CC       YPT1. YPT6 and SEC4 (By similarity). {ECO:0000250}.
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DR   EMBL; AJ001414; CAA04749.1; -; Genomic_DNA.
DR   EMBL; CR382132; CAG78927.1; -; Genomic_DNA.
DR   EMBL; M17741; AAA35241.1; -; Genomic_DNA.
DR   PIR; B26955; B26955.
DR   RefSeq; XP_506113.1; XM_506113.1.
DR   AlphaFoldDB; P09379; -.
DR   SMR; P09379; -.
DR   STRING; 4952.CAG78927; -.
DR   EnsemblFungi; CAG78927; CAG78927; YALI0_F31911g.
DR   GeneID; 2907695; -.
DR   KEGG; yli:YALI0F31911g; -.
DR   VEuPathDB; FungiDB:YALI0_F31911g; -.
DR   HOGENOM; CLU_004457_0_1_1; -.
DR   InParanoid; P09379; -.
DR   OMA; ERNQRIW; -.
DR   Proteomes; UP000001300; Chromosome F.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProt.
DR   GO; GO:0005096; F:GTPase activator activity; IBA:GO_Central.
DR   GO; GO:0090630; P:activation of GTPase activity; IBA:GO_Central.
DR   GO; GO:0032889; P:regulation of vacuole fusion, non-autophagic; IEA:EnsemblFungi.
DR   GO; GO:0016192; P:vesicle-mediated transport; IEA:EnsemblFungi.
DR   InterPro; IPR000195; Rab-GTPase-TBC_dom.
DR   InterPro; IPR035969; Rab-GTPase_TBC_sf.
DR   InterPro; IPR021935; SGSM1/2_RBD.
DR   Pfam; PF12068; PH_RBD; 1.
DR   Pfam; PF00566; RabGAP-TBC; 1.
DR   SMART; SM00164; TBC; 1.
DR   SUPFAM; SSF47923; SSF47923; 2.
DR   PROSITE; PS50086; TBC_RABGAP; 1.
PE   3: Inferred from homology;
KW   GTPase activation; Reference proteome.
FT   CHAIN           1..730
FT                   /note="GTPase-activating protein GYP7"
FT                   /id="PRO_0000208016"
FT   DOMAIN          434..619
FT                   /note="Rab-GAP TBC"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00163"
FT   CONFLICT        500
FT                   /note="R -> L (in Ref. 3; AAA35241)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   730 AA;  84026 MW;  BF2F760495FCEF1A CRC64;
     MNSLWPVSVS HTQLTSINHQ VYVHPTPSSK DNIPGFLALA KPRGATTDKE ILVAWIPESK
     LQESAADFES YVKVDIKESG TPASSSLNLA ETLVSPPPSS SFSSYAFSIP ISDIFSLQVK
     QPSLGWWWGS ITIHTRSKED QLPPLYFHDA ESQSTIMEQK RRNKKFETFD SESGSSMFWG
     GDHFIQVLSK YANLERAESD HSFLLVNPRE GDAERFGTNL TGGSEEPSQL VAGIPGRGAG
     GDPVDRGAQV QKAFSDIRWG LLSNLAKVTQ LTRKVSQGVW DSSPQPVKQL LMKPEVKKIG
     DDFDSARIYL AKWALSVAEE SQRAKLKVLF DDELRELVSD EGFELIDAEN NPQRRNEVSL
     AEWNAFFDYN GRLIVTVNEV KERIFHGGLA PAVRPEGWLF LLGVYPWDST AAERKELVSK
     LRVDYNRLKK EWWVQEDKER DDFWRDQLSR IEKDVHRTDR NITFFAECDA KKDGDDDNYD
     KDEFGFSSQI NSNIHLIQLR DMLITYNQHN KNLGYVQGMS DLLSPLYVVL QDDTLAFWAF
     SAFMERMERN YLRDQSGMRN QLLCLDHLVQ FMLPSLYKHL EKTESTNLFF FFRMLLVWFK
     RELLWDDVLR LWEVLWTDYL SSQFVLFVCL AILDKHKDVM IDHLAGFDEI LKYMNELSMT
     IDLDELLVRA ELLFYRFRRT VELIDRKNED RRNSADGSEP VSITEDLREL LSRKVIVVRE
     GERPEGVMGG