GZF3_CANAL
ID GZF3_CANAL Reviewed; 712 AA.
AC Q5A201; A0A1D8PSA7; Q5A251;
DT 16-APR-2014, integrated into UniProtKB/Swiss-Prot.
DT 15-MAR-2017, sequence version 2.
DT 25-MAY-2022, entry version 93.
DE RecName: Full=Transcriptional regulator GZF3;
GN Name=GZF3; Synonyms=DAL80; OrderedLocusNames=CAALFM_CR02850CA;
GN ORFNames=CaO19.10361, CaO19.2842;
OS Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Debaryomycetaceae; Candida/Lodderomyces clade; Candida.
OX NCBI_TaxID=237561;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SC5314 / ATCC MYA-2876;
RX PubMed=15123810; DOI=10.1073/pnas.0401648101;
RA Jones T., Federspiel N.A., Chibana H., Dungan J., Kalman S., Magee B.B.,
RA Newport G., Thorstenson Y.R., Agabian N., Magee P.T., Davis R.W.,
RA Scherer S.;
RT "The diploid genome sequence of Candida albicans.";
RL Proc. Natl. Acad. Sci. U.S.A. 101:7329-7334(2004).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=SC5314 / ATCC MYA-2876;
RX PubMed=17419877; DOI=10.1186/gb-2007-8-4-r52;
RA van het Hoog M., Rast T.J., Martchenko M., Grindle S., Dignard D.,
RA Hogues H., Cuomo C., Berriman M., Scherer S., Magee B.B., Whiteway M.,
RA Chibana H., Nantel A., Magee P.T.;
RT "Assembly of the Candida albicans genome into sixteen supercontigs aligned
RT on the eight chromosomes.";
RL Genome Biol. 8:RESEARCH52.1-RESEARCH52.12(2007).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND GENOME REANNOTATION.
RC STRAIN=SC5314 / ATCC MYA-2876;
RX PubMed=24025428; DOI=10.1186/gb-2013-14-9-r97;
RA Muzzey D., Schwartz K., Weissman J.S., Sherlock G.;
RT "Assembly of a phased diploid Candida albicans genome facilitates allele-
RT specific measurements and provides a simple model for repeat and indel
RT structure.";
RL Genome Biol. 14:RESEARCH97.1-RESEARCH97.14(2013).
RN [4]
RP INDUCTION.
RX PubMed=16545688; DOI=10.1016/j.freeradbiomed.2005.11.019;
RA Wang Y., Cao Y.Y., Jia X.M., Cao Y.B., Gao P.H., Fu X.P., Ying K.,
RA Chen W.S., Jiang Y.Y.;
RT "Cap1p is involved in multiple pathways of oxidative stress response in
RT Candida albicans.";
RL Free Radic. Biol. Med. 40:1201-1209(2006).
RN [5]
RP DISRUPTION PHENOTYPE, AND FUNCTION.
RX PubMed=20041210; DOI=10.1371/journal.pgen.1000783;
RA Homann O.R., Dea J., Noble S.M., Johnson A.D.;
RT "A phenotypic profile of the Candida albicans regulatory network.";
RL PLoS Genet. 5:E1000783-E1000783(2009).
RN [6]
RP INDUCTION.
RX PubMed=22265407; DOI=10.1016/j.cell.2011.10.048;
RA Nobile C.J., Fox E.P., Nett J.E., Sorrells T.R., Mitrovich Q.M.,
RA Hernday A.D., Tuch B.B., Andes D.R., Johnson A.D.;
RT "A recently evolved transcriptional network controls biofilm development in
RT Candida albicans.";
RL Cell 148:126-138(2012).
CC -!- FUNCTION: Probable transcription factor involved in response to
CC fluconazole, LiCl, and copper. {ECO:0000269|PubMed:20041210}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- INDUCTION: Induced via CAP1 during oxitive stress, as well as during
CC biofilm formation. {ECO:0000269|PubMed:16545688,
CC ECO:0000269|PubMed:22265407}.
CC -!- DISRUPTION PHENOTYPE: Leads to altered sensitivity to fluconazole,
CC LiCl, and copper. {ECO:0000269|PubMed:20041210}.
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DR EMBL; CP017630; AOW31025.1; -; Genomic_DNA.
DR RefSeq; XP_715773.2; XM_710680.2.
DR AlphaFoldDB; Q5A201; -.
DR SMR; Q5A201; -.
DR BioGRID; 1225650; 2.
DR STRING; 237561.Q5A201; -.
DR PRIDE; Q5A201; -.
DR GeneID; 3642563; -.
DR KEGG; cal:CAALFM_CR02850CA; -.
DR CGD; CAL0000183131; GZF3.
DR VEuPathDB; FungiDB:CR_02850C_A; -.
DR eggNOG; KOG1601; Eukaryota.
DR HOGENOM; CLU_027626_0_0_1; -.
DR OrthoDB; 1466754at2759; -.
DR PRO; PR:Q5A201; -.
DR Proteomes; UP000000559; Chromosome R.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:0071280; P:cellular response to copper ion; IMP:CGD.
DR GO; GO:0034605; P:cellular response to heat; IMP:CGD.
DR GO; GO:0071285; P:cellular response to lithium ion; IMP:CGD.
DR GO; GO:0030447; P:filamentous growth; IMP:CGD.
DR GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR CDD; cd00202; ZnF_GATA; 1.
DR Gene3D; 3.30.50.10; -; 1.
DR InterPro; IPR039355; Transcription_factor_GATA.
DR InterPro; IPR000679; Znf_GATA.
DR InterPro; IPR013088; Znf_NHR/GATA.
DR PANTHER; PTHR10071; PTHR10071; 1.
DR Pfam; PF00320; GATA; 1.
DR PRINTS; PR00619; GATAZNFINGER.
DR SMART; SM00401; ZnF_GATA; 1.
DR PROSITE; PS00344; GATA_ZN_FINGER_1; 1.
DR PROSITE; PS50114; GATA_ZN_FINGER_2; 1.
PE 2: Evidence at transcript level;
KW Coiled coil; Metal-binding; Nucleus; Reference proteome; Stress response;
KW Zinc; Zinc-finger.
FT CHAIN 1..712
FT /note="Transcriptional regulator GZF3"
FT /id="PRO_0000426081"
FT ZN_FING 135..159
FT /note="GATA-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00094"
FT REGION 1..20
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 27..135
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 173..280
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 377..533
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 596..712
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 545..598
FT /evidence="ECO:0000255"
FT COMPBIAS 27..56
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 83..107
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 108..135
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 183..205
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 222..266
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 377..450
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 462..533
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 596..676
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 712 AA; 75916 MW; 7E3EAB0AA493BA50 CRC64;
MSMSDIQQRP QIPTTTTAAV AAAASTNVNT GAATTSTATT GNTPTTTPTS PIENISKVPV
KPSVDVPVKP KLEQQQQQQS EQSSKPPPPP PEQQQQHQLP TPPIKPPKTG TTSSSSSTTT
SSATSSKISM SGPVCGNCQT QTTPLWRRDE TGQVLCNACG LFLKLHGRPR PISLKTDTIK
SRNRVKQNGS NSQSSKSSGA NTPELKSKEG KSGKKSPKSK KKSLGNGNGN GNSSHDHNTL
TPLLPATSNN TPTFKSTTSQ SQHQQNQNHH HQHHNHHHHL PNHVLQTHQV PLHYPSSTPT
QFAPGLQRIT SPLLLSTTSS SSSIRTEPNN NNTSKLTPIQ AAAGALENMS NELGPSATFK
KGNNINGISL MNKTKKDVSS INGSSTSLSS SSASSSIFSS VAPSTSSSSS LSNGTTINNP
APKLPTLGSK ISSPSSQPFT RSTTPLQTLP PLHKIASHES SLPPLHNIST YNNNNSGGGA
DGGQQSMANY SQTNRSPING NQDNNNNNNN NNNNNNNGNN NGNNNSNNNG NNFTASAHEV
TLLKTRISEL ELVNDLYRTR IMELEAMEQA ARLRENSMKK RLDEVMNLQI NYQNLLNNNG
GMSSQTQPQP SQQPQQAGQY YSNNNNNNNN DQGSQSISPN VSITGSTTIT SPNSRSKIIS
ETTPTHHQQQ QGGVGAGDNE SIILPPLKRN RTDELTDANG NGNGNDNKKV KI
