G_BPPHK
ID G_BPPHK Reviewed; 187 AA.
AC Q38042; Q8W5S4;
DT 01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1997, sequence version 1.
DT 25-MAY-2022, entry version 88.
DE RecName: Full=Major spike protein G;
DE AltName: Full=G protein;
DE AltName: Full=GPG;
GN Name=G;
OS Enterobacteria phage phiK (Bacteriophage phi-K).
OC Viruses; Monodnaviria; Sangervirae; Phixviricota; Malgrandaviricetes;
OC Petitvirales; Microviridae; Bullavirinae; Alphatrevirus.
OX NCBI_TaxID=10848;
OH NCBI_TaxID=562; Escherichia coli.
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] (PHI-K AND MUTANT PHI KHT).
RX PubMed=8827438; DOI=10.1093/oxfordjournals.jbchem.a021348;
RA Kodaira K., Oki M., Kakikawa M., Kimoto H., Taketo A.;
RT "The virion proteins encoded by bacteriophage phi K and its host-range
RT mutant phi KhT: host-range determination and DNA binding properties.";
RL J. Biochem. 119:1062-1069(1996).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC RNA] OF 165-187.
RX PubMed=387790; DOI=10.1016/s0021-9258(19)86359-7;
RA Sims J., Capon D., Dressler D.;
RT "dnaG (primase)-dependent origins of DNA replication. Nucleotide sequences
RT of the negative strand initiation sites of bacteriophages St-1, phi K, and
RT alpha 3.";
RL J. Biol. Chem. 254:12615-12628(1979).
CC -!- FUNCTION: Attaches the circulating virion to the bacterial
CC lipopolysaccharides which serve as receptor for the virus. Determines
CC the phage host-range. Probably triggers with protein H the injection of
CC the phage DNA into the host cytoplasm upon conformational changes
CC induced by the interaction with host lipopolysaccharides (By
CC similarity). {ECO:0000250}.
CC -!- SUBUNIT: The virion is composed of 60 copies each of the F, G, and J
CC proteins, and 12 copies of the H protein. There are 12 spikes which are
CC each composed of 5 G and one H proteins.
CC -!- SUBCELLULAR LOCATION: Virion {ECO:0000305}.
CC -!- MISCELLANEOUS: Phi KhT, a host-range mutant of phi K, can grow on
CC E.coli C and B, besides K12, and is more thermosensitive than the
CC parental phage phi K.
CC -!- SIMILARITY: Belongs to the microvirus G protein family. {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; X60323; CAA42892.1; -; Genomic_DNA.
DR EMBL; M10726; AAA32364.2; -; Genomic_RNA.
DR PIR; JC4806; JC4806.
DR RefSeq; NP_043950.1; NC_001730.1.
DR SMR; Q38042; -.
DR GeneID; 1261200; -.
DR KEGG; vg:1261200; -.
DR Proteomes; UP000002122; Genome.
DR GO; GO:0019028; C:viral capsid; IEA:UniProtKB-KW.
DR GO; GO:0019048; P:modulation by virus of host process; IEA:InterPro.
DR GO; GO:0046718; P:viral entry into host cell; IEA:UniProtKB-KW.
DR GO; GO:0019062; P:virion attachment to host cell; IEA:UniProtKB-KW.
DR Gene3D; 2.60.120.20; -; 1.
DR InterPro; IPR016184; Capsid/spike_ssDNA_virus.
DR InterPro; IPR003515; Spike_G.
DR InterPro; IPR029053; Viral_coat.
DR Pfam; PF02306; Phage_G; 1.
DR PIRSF; PIRSF004159; Spike_G; 1.
DR SUPFAM; SSF88645; SSF88645; 1.
PE 3: Inferred from homology;
KW Capsid protein; Host-virus interaction; Viral attachment to host cell;
KW Viral genome ejection through host cell envelope;
KW Viral penetration into host cytoplasm; Virion; Virus entry into host cell.
FT CHAIN 1..187
FT /note="Major spike protein G"
FT /id="PRO_0000164894"
FT VARIANT 75
FT /note="A -> S (in phi KhT mutant)"
SQ SEQUENCE 187 AA; 19569 MW; C5C5CEC891241701 CRC64;
MYQIFVTKHD TAIQTSRFSV TGSITPVAPT GNIPVINTGN ITAEHAVVSL YANLTAGTSS
DGSFIVAMKV DTSPADPNCV ISAGVNLSFA GTSYPIVGIV RFESASDQPT SIAGSQIEHY
PIEMSVGSGG VCSARDCVTV DIHPRAFGNN VFVGVICSSA KWTSGRVLGT IATTQVIREY
QVLQPLK