ID   H10A_XENLA              Reviewed;         194 AA.
AC   P22845; Q7SZ41; Q91759;
DT   01-AUG-1991, integrated into UniProtKB/Swiss-Prot.
DT   14-NOV-2006, sequence version 3.
DT   03-AUG-2022, entry version 96.
DE   RecName: Full=Histone H1.0-A;
DE   AltName: Full=H1-SB;
DE   AltName: Full=H1E;
DE   AltName: Full=Histone H1(0)-1;
DE   AltName: Full=Histone H5B;
DE   AltName: Full=XlH5B;
GN   Name=h1-0-a;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Erythroid cell;
RX   PubMed=2907322; DOI=10.1016/0378-1119(88)90110-2;
RA   Rutledge R.G., Neelin J.M., Seligy V.L.;
RT   "Isolation and expression of cDNA clones coding for two sequence variants
RT   of Xenopus laevis histone H5.";
RL   Gene 70:117-126(1988).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=9161423; DOI=10.1016/s0378-1119(96)00845-1;
RA   Brocard M., Triebe S., Peretti M., Doenecke D., Khochbin S.;
RT   "Characterization of the two H1(0)-encoding genes from Xenopus laevis.";
RL   Gene 189:127-134(1997).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Embryo;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Histones H1 are necessary for the condensation of nucleosome
CC       chains into higher-order structures. The histones H1.0 are found in
CC       cells that are in terminal stages of differentiation or that have low
CC       rates of cell division (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus. Chromosome.
CC   -!- SIMILARITY: Belongs to the histone H1/H5 family. {ECO:0000255|PROSITE-
CC       ProRule:PRU00837}.
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DR   EMBL; M22835; -; NOT_ANNOTATED_CDS; mRNA.
DR   EMBL; Z71502; CAA96129.1; -; Genomic_DNA.
DR   EMBL; BC054149; AAH54149.1; -; mRNA.
DR   EMBL; BC072941; AAH72941.1; -; mRNA.
DR   PIR; A30484; A30484.
DR   RefSeq; NP_001082697.1; NM_001089228.1.
DR   AlphaFoldDB; P22845; -.
DR   SMR; P22845; -.
DR   BioGRID; 99992; 3.
DR   DNASU; 398662; -.
DR   GeneID; 398662; -.
DR   KEGG; xla:398662; -.
DR   CTD; 398662; -.
DR   Xenbase; XB-GENE-865333; h1-0.L.
DR   OMA; PTYSDMI; -.
DR   OrthoDB; 1565299at2759; -.
DR   Proteomes; UP000186698; Chromosome 4L.
DR   Bgee; 398662; Expressed in internal ear and 20 other tissues.
DR   GO; GO:0000786; C:nucleosome; IEA:InterPro.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0030527; F:structural constituent of chromatin; IEA:InterPro.
DR   GO; GO:0030261; P:chromosome condensation; IEA:UniProtKB-KW.
DR   GO; GO:0006334; P:nucleosome assembly; IEA:InterPro.
DR   CDD; cd00073; H15; 1.
DR   Gene3D; 1.10.10.10; -; 1.
DR   InterPro; IPR005819; H1/H5.
DR   InterPro; IPR005818; Histone_H1/H5_H15.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   Pfam; PF00538; Linker_histone; 1.
DR   PRINTS; PR00624; HISTONEH5.
DR   SMART; SM00526; H15; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   PROSITE; PS51504; H15; 1.
PE   2: Evidence at transcript level;
KW   Chromosome; DNA condensation; DNA-binding; Nucleus; Reference proteome.
FT   CHAIN           1..194
FT                   /note="Histone H1.0-A"
FT                   /id="PRO_0000196009"
FT   DOMAIN          22..95
FT                   /note="H15"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00837"
FT   REGION          1..29
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          96..194
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        105..194
FT                   /note="Basic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   UNSURE          169
FT                   /note="W or R"
FT   CONFLICT        37
FT                   /note="E -> K (in Ref. 1; M22835)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   194 AA;  21016 MW;  AE110359FECD8BF7 CRC64;
     MTENSAPAAK PRRSKASKKS TDHPKYSDMI LDAVQAEKSR SGSSRQSIQK YIKNNYTVGE
     NADSQIKLSI KRLVTSGTLK QTKGVGASGS FRLAKADEVK KPAKKPKKEI KKAVSPKKAA
     KPKKAAKSPA KAKKPKVAEK KVKKAPKKKP APSPRKAKKT KTVRAKPVWA SKAKKAKPSK
     PKAKASPKKS GRKK