H11L_CHICK
ID H11L_CHICK Reviewed; 225 AA.
AC P08287;
DT 01-AUG-1988, integrated into UniProtKB/Swiss-Prot.
DT 23-JAN-2007, sequence version 2.
DT 03-AUG-2022, entry version 140.
DE RecName: Full=Histone H1.11L;
OS Gallus gallus (Chicken).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC Phasianinae; Gallus.
OX NCBI_TaxID=9031;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=3597432; DOI=10.1016/s0021-9258(18)47984-7;
RA Coles L.S., Robins A.J., Madley L.K., Wells J.R.E.;
RT "Characterization of the chicken histone H1 gene complement. Generation of
RT a complete set of vertebrate H1 protein sequences.";
RL J. Biol. Chem. 262:9656-9663(1987).
RN [2]
RP STRUCTURE BY NMR OF 41-114.
RX PubMed=8218199; DOI=10.1021/bi00093a011;
RA Cerf C., Lippens G., Muyldermans S., Segers A., Ramakrishnan V.,
RA Wodak S.J., Hallenga K., Wyns L.;
RT "Homo- and heteronuclear two-dimensional NMR studies of the globular domain
RT of histone H1: sequential assignment and secondary structure.";
RL Biochemistry 32:11345-11351(1993).
CC -!- FUNCTION: Histones H1 are necessary for the condensation of nucleosome
CC chains into higher-order structures.
CC -!- SUBCELLULAR LOCATION: Nucleus. Chromosome.
CC -!- SIMILARITY: Belongs to the histone H1/H5 family. {ECO:0000255|PROSITE-
CC ProRule:PRU00837}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; M17019; AAA48789.1; -; Genomic_DNA.
DR PIR; B28456; B28456.
DR RefSeq; NP_001035733.1; NM_001040643.1.
DR PDB; 1GHC; NMR; -; A=41-114.
DR PDBsum; 1GHC; -.
DR AlphaFoldDB; P08287; -.
DR SMR; P08287; -.
DR STRING; 9031.ENSGALP00000037266; -.
DR PaxDb; P08287; -.
DR GeneID; 427892; -.
DR KEGG; gga:427892; -.
DR CTD; 427892; -.
DR VEuPathDB; HostDB:geneid_427892; -.
DR eggNOG; KOG4012; Eukaryota.
DR HOGENOM; CLU_052897_7_0_1; -.
DR InParanoid; P08287; -.
DR OrthoDB; 1565299at2759; -.
DR TreeFam; TF313664; -.
DR EvolutionaryTrace; P08287; -.
DR PRO; PR:P08287; -.
DR Proteomes; UP000000539; Unplaced.
DR GO; GO:0000786; C:nucleosome; IEA:InterPro.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0003690; F:double-stranded DNA binding; IBA:GO_Central.
DR GO; GO:0031492; F:nucleosomal DNA binding; IBA:GO_Central.
DR GO; GO:0030527; F:structural constituent of chromatin; IEA:InterPro.
DR GO; GO:0030261; P:chromosome condensation; IBA:GO_Central.
DR GO; GO:0045910; P:negative regulation of DNA recombination; IBA:GO_Central.
DR GO; GO:0006334; P:nucleosome assembly; IEA:InterPro.
DR CDD; cd00073; H15; 1.
DR Gene3D; 1.10.10.10; -; 1.
DR InterPro; IPR005819; H1/H5.
DR InterPro; IPR005818; Histone_H1/H5_H15.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR Pfam; PF00538; Linker_histone; 1.
DR PRINTS; PR00624; HISTONEH5.
DR SMART; SM00526; H15; 1.
DR SUPFAM; SSF46785; SSF46785; 1.
DR PROSITE; PS51504; H15; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Acetylation; Chromosome; DNA-binding; Nucleus;
KW Reference proteome.
FT INIT_MET 1
FT /note="Removed"
FT CHAIN 2..225
FT /note="Histone H1.11L"
FT /id="PRO_0000195931"
FT DOMAIN 41..114
FT /note="H15"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00837"
FT REGION 1..46
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 94..225
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 94..108
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 127..167
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 199..225
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 2
FT /note="N-acetylserine"
FT /evidence="ECO:0000250"
FT STRAND 42..44
FT /evidence="ECO:0007829|PDB:1GHC"
FT HELIX 45..55
FT /evidence="ECO:0007829|PDB:1GHC"
FT STRAND 57..60
FT /evidence="ECO:0007829|PDB:1GHC"
FT HELIX 67..69
FT /evidence="ECO:0007829|PDB:1GHC"
FT STRAND 70..75
FT /evidence="ECO:0007829|PDB:1GHC"
FT STRAND 78..81
FT /evidence="ECO:0007829|PDB:1GHC"
FT HELIX 82..88
FT /evidence="ECO:0007829|PDB:1GHC"
FT TURN 89..91
FT /evidence="ECO:0007829|PDB:1GHC"
FT HELIX 92..95
FT /evidence="ECO:0007829|PDB:1GHC"
SQ SEQUENCE 225 AA; 22528 MW; BFDA6897A7D5599F CRC64;
MSETAPAPAA EAAPAAAPAP AKAAAKKPKK AAGGAKARKP AGPSVTELIT KAVSASKERK
GLSLAALKKA LAAGGYDVEK NNSRIKLGLK SLVSKGTLVQ TKGTGASGSF RLSKKPGEVK
EKAPKKKASA AKPKKPAAKK PAAAAKKPKK AVAVKKSPKK AKKPAASATK KSAKSPKKVT
KAVKPKKAVA AKSPAKAKAV KPKAAKPKAA KPKAAKAKKA AAKKK
