H12A3_CYRHA
ID H12A3_CYRHA Reviewed; 97 AA.
AC D2Y2H7;
DT 02-NOV-2010, integrated into UniProtKB/Swiss-Prot.
DT 02-MAR-2010, sequence version 1.
DT 25-MAY-2022, entry version 25.
DE RecName: Full=U6-theraphotoxin-Hhn1a 3;
DE Short=U6-TRTX-Hhn1a;
DE AltName: Full=Hainantoxin-XII.3 {ECO:0000312|EMBL:ADB56870.1};
DE Short=HNTX-XII.3 {ECO:0000312|EMBL:ADB56870.1};
DE Flags: Precursor;
OS Cyriopagopus hainanus (Chinese bird spider) (Haplopelma hainanum).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Chelicerata; Arachnida; Araneae;
OC Mygalomorphae; Theraphosidae; Haplopelma.
OX NCBI_TaxID=209901;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Venom gland;
RX PubMed=20192277; DOI=10.1021/pr1000016;
RA Tang X., Zhang Y., Hu W., Xu D., Tao H., Yang X., Li Y., Jiang L.,
RA Liang S.;
RT "Molecular diversification of peptide toxins from the tarantula Haplopelma
RT hainanum (Ornithoctonus hainana) venom based on transcriptomic, peptidomic,
RT and genomic analyses.";
RL J. Proteome Res. 9:2550-2564(2010).
CC -!- FUNCTION: Ion channel inhibitor. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC -!- TISSUE SPECIFICITY: Expressed by the venom gland.
CC -!- DOMAIN: The presence of a 'disulfide through disulfide knot'
CC structurally defines this protein as a knottin. {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the neurotoxin 10 (Hwtx-1) family. 12 (Hntx-12)
CC subfamily. {ECO:0000305}.
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DR EMBL; GU293054; ADB56870.1; -; mRNA.
DR AlphaFoldDB; D2Y2H7; -.
DR SMR; D2Y2H7; -.
DR ArachnoServer; AS001585; U6-theraphotoxin-Hhn1a.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0008200; F:ion channel inhibitor activity; IEA:InterPro.
DR GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
DR InterPro; IPR011696; Huwentoxin-1.
DR InterPro; IPR013140; Huwentoxin_CS1.
DR Pfam; PF07740; Toxin_12; 1.
DR PROSITE; PS60021; HWTX_1; 1.
PE 2: Evidence at transcript level;
KW Disulfide bond; Ion channel impairing toxin; Knottin; Secreted; Signal;
KW Toxin.
FT SIGNAL 1..33
FT /evidence="ECO:0000255"
FT PROPEP 34..61
FT /evidence="ECO:0000250"
FT /id="PRO_0000400675"
FT PEPTIDE 62..97
FT /note="U6-theraphotoxin-Hhn1a 3"
FT /id="PRO_0000400676"
FT DISULFID 63..77
FT /evidence="ECO:0000250"
FT DISULFID 70..82
FT /evidence="ECO:0000250"
FT DISULFID 76..89
FT /evidence="ECO:0000250"
SQ SEQUENCE 97 AA; 11184 MW; A48A27D8983DDC9F CRC64;
MLIKQFSRRS KNTKVQILLA FAALFVLAVG SYASESKKLD LRDALFSAMF SADYQLNPQE
RGCRYFLGEC KKTSECCEHL ACHDKHKWCA WDWTIGK