ID   H12E_PARAN              Reviewed;          62 AA.
AC   Q99282;
DT   23-JAN-2007, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1997, sequence version 1.
DT   25-MAY-2022, entry version 69.
DE   RecName: Full=Histone H1.2, embryonic;
DE   Flags: Fragments;
OS   Parechinus angulosus (Angulate sea urchin) (Cidaris angulosus).
OC   Eukaryota; Metazoa; Echinodermata; Eleutherozoa; Echinozoa; Echinoidea;
OC   Euechinoidea; Echinacea; Camarodonta; Echinidea; Echinidae; Parechinus.
OX   NCBI_TaxID=7658;
RN   [1] {ECO:0000305}
RP   PROTEIN SEQUENCE, AND VARIANT GLY-7.
RC   TISSUE=Embryo {ECO:0000269|PubMed:6615845};
RX   PubMed=6615845; DOI=10.1016/0167-4838(83)90106-1;
RA   de Groot P., Strickland W.N., Brandt W.F., von Holt C.;
RT   "The identification by sequence homology of stage-specific sea urchin
RT   embryo histones H1.";
RL   Biochim. Biophys. Acta 747:276-283(1983).
CC   -!- FUNCTION: Histones H1 are necessary for the condensation of nucleosome
CC       chains into higher-order structures.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}. Chromosome.
CC   -!- SIMILARITY: Belongs to the histone H1/H5 family. {ECO:0000255|PROSITE-
CC       ProRule:PRU00837}.
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DR   AlphaFoldDB; Q99282; -.
DR   SMR; Q99282; -.
DR   GO; GO:0000786; C:nucleosome; IEA:InterPro.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0006334; P:nucleosome assembly; IEA:InterPro.
DR   CDD; cd00073; H15; 1.
DR   Gene3D; 1.10.10.10; -; 1.
DR   InterPro; IPR005818; Histone_H1/H5_H15.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   Pfam; PF00538; Linker_histone; 1.
DR   SMART; SM00526; H15; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   PROSITE; PS51504; H15; 1.
PE   1: Evidence at protein level;
KW   Chromosome; Direct protein sequencing; DNA-binding; Nucleus.
FT   CHAIN           <1..>62
FT                   /note="Histone H1.2, embryonic"
FT                   /id="PRO_0000273525"
FT   DOMAIN          1..53
FT                   /note="H15"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00837"
FT   VARIANT         7
FT                   /note="T -> G"
FT                   /evidence="ECO:0000269|PubMed:6615845"
FT   NON_CONS        16..17
FT                   /evidence="ECO:0000303|PubMed:6615845"
FT   NON_TER         1
FT                   /evidence="ECO:0000303|PubMed:6615845"
FT   NON_TER         62
FT                   /evidence="ECO:0000303|PubMed:6615845"
SQ   SEQUENCE   62 AA;  6339 MW;  DD814777864E0FF9 CRC64;
     HVVAAITALK ERGGSSMKKQ SVFIKKALKS GVEKGTLVQV KGKGASGSFK LGKKPAAGRT
     DA