H13A6_CYRHA
ID H13A6_CYRHA Reviewed; 90 AA.
AC D2Y2B4;
DT 02-NOV-2010, integrated into UniProtKB/Swiss-Prot.
DT 02-MAR-2010, sequence version 1.
DT 25-MAY-2022, entry version 27.
DE RecName: Full=U7-theraphotoxin-Hhn1a 6;
DE Short=U7-TRTX-Hhn1a;
DE AltName: Full=Hainantoxin-XIII.6;
DE Short=HNTX-XIII.6;
DE Flags: Precursor;
OS Cyriopagopus hainanus (Chinese bird spider) (Haplopelma hainanum).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Chelicerata; Arachnida; Araneae;
OC Mygalomorphae; Theraphosidae; Haplopelma.
OX NCBI_TaxID=209901;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Venom gland;
RX PubMed=20192277; DOI=10.1021/pr1000016;
RA Tang X., Zhang Y., Hu W., Xu D., Tao H., Yang X., Li Y., Jiang L.,
RA Liang S.;
RT "Molecular diversification of peptide toxins from the tarantula Haplopelma
RT hainanum (Ornithoctonus hainana) venom based on transcriptomic, peptidomic,
RT and genomic analyses.";
RL J. Proteome Res. 9:2550-2564(2010).
CC -!- FUNCTION: Ion channel inhibitor. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC -!- TISSUE SPECIFICITY: Expressed by the venom gland.
CC -!- DOMAIN: The presence of a 'disulfide through disulfide knot'
CC structurally defines this protein as a knottin. {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the neurotoxin 10 (Hwtx-1) family. 13 (Hntx-13)
CC subfamily. {ECO:0000305}.
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DR EMBL; GU292991; ADB56807.1; -; mRNA.
DR AlphaFoldDB; D2Y2B4; -.
DR ArachnoServer; AS001986; U7-theraphotoxin-Hhn1a.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0008200; F:ion channel inhibitor activity; IEA:InterPro.
DR GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
DR InterPro; IPR011696; Huwentoxin-1.
DR Pfam; PF07740; Toxin_12; 1.
PE 2: Evidence at transcript level;
KW Disulfide bond; Ion channel impairing toxin; Knottin; Secreted; Signal;
KW Toxin.
FT SIGNAL 1..19
FT /evidence="ECO:0000255"
FT PROPEP 20..50
FT /evidence="ECO:0000250"
FT /id="PRO_0000400689"
FT PEPTIDE 51..90
FT /note="U7-theraphotoxin-Hhn1a 6"
FT /id="PRO_0000400690"
FT DISULFID 51..65
FT /evidence="ECO:0000250"
FT DISULFID 58..70
FT /evidence="ECO:0000250"
FT DISULFID 64..81
FT /evidence="ECO:0000250"
SQ SEQUENCE 90 AA; 10611 MW; DA95125074CED751 CRC64;
MKTAIFTVVL ALAVFAVLSF GWEANEKALS EEFTELIHEK EAASEAEARE CRYFWGECHD
HMPCCDWLVC RYKWPITYNI CVWNRTFPEK