ID   H14C2_CYRHA             Reviewed;          84 AA.
AC   D2Y2E2;
DT   02-NOV-2010, integrated into UniProtKB/Swiss-Prot.
DT   02-MAR-2010, sequence version 1.
DT   25-MAY-2022, entry version 24.
DE   RecName: Full=U8-theraphotoxin-Hhn1c 2;
DE            Short=U8-TRTX-Hhn1c 2;
DE   AltName: Full=Hainantoxin-XIV-3.2 {ECO:0000312|EMBL:ADB56835.1};
DE            Short=HNTX-XIV-3.2 {ECO:0000312|EMBL:ADB56835.1};
DE   Flags: Precursor;
OS   Cyriopagopus hainanus (Chinese bird spider) (Haplopelma hainanum).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Chelicerata; Arachnida; Araneae;
OC   Mygalomorphae; Theraphosidae; Haplopelma.
OX   NCBI_TaxID=209901;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Venom gland;
RX   PubMed=20192277; DOI=10.1021/pr1000016;
RA   Tang X., Zhang Y., Hu W., Xu D., Tao H., Yang X., Li Y., Jiang L.,
RA   Liang S.;
RT   "Molecular diversification of peptide toxins from the tarantula Haplopelma
RT   hainanum (Ornithoctonus hainana) venom based on transcriptomic, peptidomic,
RT   and genomic analyses.";
RL   J. Proteome Res. 9:2550-2564(2010).
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC   -!- TISSUE SPECIFICITY: Expressed by the venom gland.
CC   -!- SIMILARITY: Belongs to the AVIT (prokineticin) family. {ECO:0000305}.
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DR   EMBL; GU293019; ADB56835.1; -; mRNA.
DR   AlphaFoldDB; D2Y2E2; -.
DR   SMR; D2Y2E2; -.
DR   ArachnoServer; AS001663; U8-theraphotoxin-Hhn1c.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
DR   InterPro; IPR023569; Prokineticin_domain.
DR   Pfam; PF06607; Prokineticin; 1.
PE   2: Evidence at transcript level;
KW   Disulfide bond; Secreted; Signal; Toxin.
FT   SIGNAL          1..21
FT                   /evidence="ECO:0000255"
FT   CHAIN           22..84
FT                   /note="U8-theraphotoxin-Hhn1c 2"
FT                   /id="PRO_0000400850"
FT   DISULFID        23..35
FT                   /evidence="ECO:0000250|UniProtKB:Q9PW66"
FT   DISULFID        29..44
FT                   /evidence="ECO:0000250|UniProtKB:Q9PW66"
FT   DISULFID        34..67
FT                   /evidence="ECO:0000250|UniProtKB:Q9PW66"
FT   DISULFID        54..75
FT                   /evidence="ECO:0000250|UniProtKB:Q9PW66"
FT   DISULFID        69..81
FT                   /evidence="ECO:0000250|UniProtKB:Q9PW66"
SQ   SEQUENCE   84 AA;  9308 MW;  F77DDD2797B461B8 CRC64;
     MKVVLLVCLV WMMAMMELVS CECWSQADCS DGHCCAGSSF SKNCRPYGGD GEQCEPRNKY
     EVYSTGCPCE ENLMCSVINR CQSA