H14_CAEEL
ID H14_CAEEL Reviewed; 253 AA.
AC O17536; O17426;
DT 11-OCT-2004, integrated into UniProtKB/Swiss-Prot.
DT 23-JAN-2007, sequence version 3.
DT 03-AUG-2022, entry version 116.
DE RecName: Full=Histone H1.4;
DE AltName: Full=Histone H1-like protein 4;
GN Name=hil-4; ORFNames=C18G1.5;
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
RC STRAIN=Bristol N2;
RX PubMed=11245572; DOI=10.1242/dev.128.7.1069;
RA Jedrusik M.A., Schulze E.;
RT "A single histone H1 isoform (H1.1) is essential for chromatin silencing
RT and germline development in Caenorhabditis elegans.";
RL Development 128:1069-1080(2001).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2;
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
CC -!- FUNCTION: Histones H1 are necessary for the condensation of nucleosome
CC chains into higher-order structures. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00837}.
CC Chromosome {ECO:0000255|PROSITE-ProRule:PRU00837}.
CC -!- SIMILARITY: Belongs to the histone H1/H5 family. {ECO:0000255|PROSITE-
CC ProRule:PRU00837}.
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DR EMBL; AF005371; AAB81029.1; -; mRNA.
DR EMBL; AF026521; AAB82588.1; -; Genomic_DNA.
DR EMBL; FO080620; CCD65228.1; -; Genomic_DNA.
DR PIR; F89030; F89030.
DR PIR; T37247; T37247.
DR RefSeq; NP_504277.1; NM_071876.4.
DR AlphaFoldDB; O17536; -.
DR SMR; O17536; -.
DR STRING; 6239.C18G1.5; -.
DR iPTMnet; O17536; -.
DR EPD; O17536; -.
DR PaxDb; O17536; -.
DR PeptideAtlas; O17536; -.
DR PRIDE; O17536; -.
DR EnsemblMetazoa; C18G1.5.1; C18G1.5.1; WBGene00001855.
DR GeneID; 178866; -.
DR UCSC; C18G1.5.1; c. elegans.
DR CTD; 178866; -.
DR WormBase; C18G1.5; CE17421; WBGene00001855; hil-4.
DR eggNOG; KOG4012; Eukaryota.
DR GeneTree; ENSGT00970000195980; -.
DR HOGENOM; CLU_052897_1_1_1; -.
DR InParanoid; O17536; -.
DR OMA; QFKIAKF; -.
DR OrthoDB; 1565299at2759; -.
DR PRO; PR:O17536; -.
DR Proteomes; UP000001940; Chromosome V.
DR Bgee; WBGene00001855; Expressed in germ line (C elegans) and 4 other tissues.
DR GO; GO:0000786; C:nucleosome; IEA:InterPro.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0003690; F:double-stranded DNA binding; IBA:GO_Central.
DR GO; GO:0031492; F:nucleosomal DNA binding; IBA:GO_Central.
DR GO; GO:0030527; F:structural constituent of chromatin; IEA:InterPro.
DR GO; GO:0030261; P:chromosome condensation; IBA:GO_Central.
DR GO; GO:0045910; P:negative regulation of DNA recombination; IBA:GO_Central.
DR GO; GO:0006334; P:nucleosome assembly; IEA:InterPro.
DR CDD; cd00073; H15; 1.
DR Gene3D; 1.10.10.10; -; 1.
DR InterPro; IPR005819; H1/H5.
DR InterPro; IPR005818; Histone_H1/H5_H15.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR Pfam; PF00538; Linker_histone; 1.
DR PRINTS; PR00624; HISTONEH5.
DR SMART; SM00526; H15; 1.
DR SUPFAM; SSF46785; SSF46785; 1.
DR PROSITE; PS51504; H15; 1.
PE 2: Evidence at transcript level;
KW Acetylation; Chromosome; DNA-binding; Nucleus; Reference proteome.
FT INIT_MET 1
FT /note="Removed"
FT /evidence="ECO:0000250|UniProtKB:P10771"
FT CHAIN 2..253
FT /note="Histone H1.4"
FT /id="PRO_0000195984"
FT DOMAIN 51..127
FT /note="H15"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00837"
FT REGION 1..43
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 134..253
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 14..37
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 2
FT /note="N-acetylserine"
FT /evidence="ECO:0000250|UniProtKB:P10771"
FT CONFLICT 33
FT /note="S -> P (in Ref. 1; AAB82588)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 253 AA; 25958 MW; 0D4515C58B7FE6C9 CRC64;
MSDVAVAADT TETPAAPTKA SKATKASKAT KASKATKAKT TKVPMVKADA AHPPFINMVT
EAISSIKDRK GPSRAAILKY ITTKYTLGDQ ANKINAHLRK ALNKGLESNA FVQASGNGAN
GRFRLAEKTA SVAKSPAAAK KDATGEKKAT TTVAKKAATG EKKATTTVAK KAATGEKKAT
TTVAKKAAAG DKAKKTEVKV KKVKSPKKIA KSPVNKVTKS PVKKIAKSSS MKAAPKKAAA
KPAKKAPAAA PEA
