H15_DROME
ID H15_DROME Reviewed; 660 AA.
AC Q94890; Q9VMR3;
DT 01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT 08-NOV-2005, sequence version 2.
DT 03-AUG-2022, entry version 154.
DE RecName: Full=T-box protein H15;
GN Name=H15; ORFNames=CG6604;
OS Drosophila melanogaster (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7227;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Eye;
RX PubMed=8703069; DOI=10.1126/science.273.5280.1373;
RA Brook W.J., Cohen S.M.;
RT "Antagonistic interactions between wingless and decapentaplegic responsible
RT for dorsal-ventral pattern in the Drosophila Leg.";
RL Science 273:1373-1377(1996).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley;
RX PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A.,
RA An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F.,
RA Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F.,
RA Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
RA Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R.,
RA Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y.,
RA Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T.,
RA Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S.,
RA Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W.,
RA Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M.,
RA Venter J.C.;
RT "The genome sequence of Drosophila melanogaster.";
RL Science 287:2185-2195(2000).
RN [3]
RP GENOME REANNOTATION.
RC STRAIN=Berkeley;
RX PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT review.";
RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Berkeley;
RA Stapleton M., Carlson J.W., Chavez C., Frise E., George R.A., Pacleb J.M.,
RA Park S., Wan K.H., Yu C., Celniker S.E.;
RL Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00201}.
CC -!- SEQUENCE CAUTION:
CC Sequence=CAA67304.1; Type=Frameshift; Evidence={ECO:0000305};
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DR EMBL; X98766; CAA67304.1; ALT_FRAME; mRNA.
DR EMBL; AE014134; AAF52249.1; -; Genomic_DNA.
DR EMBL; BT022140; AAY51535.1; -; mRNA.
DR RefSeq; NP_608926.2; NM_135082.3.
DR AlphaFoldDB; Q94890; -.
DR SMR; Q94890; -.
DR BioGRID; 59938; 5.
DR IntAct; Q94890; 9.
DR STRING; 7227.FBpp0078710; -.
DR PaxDb; Q94890; -.
DR DNASU; 33769; -.
DR EnsemblMetazoa; FBtr0079076; FBpp0078710; FBgn0016660.
DR GeneID; 33769; -.
DR KEGG; dme:Dmel_CG6604; -.
DR CTD; 109804; -.
DR FlyBase; FBgn0016660; H15.
DR VEuPathDB; VectorBase:FBgn0016660; -.
DR eggNOG; KOG3586; Eukaryota.
DR GeneTree; ENSGT00940000168440; -.
DR HOGENOM; CLU_014430_9_2_1; -.
DR InParanoid; Q94890; -.
DR OMA; CNCDDLM; -.
DR OrthoDB; 1201455at2759; -.
DR PhylomeDB; Q94890; -.
DR BioGRID-ORCS; 33769; 0 hits in 1 CRISPR screen.
DR GenomeRNAi; 33769; -.
DR PRO; PR:Q94890; -.
DR Proteomes; UP000000803; Chromosome 2L.
DR Bgee; FBgn0016660; Expressed in atrium (Drosophila) and 7 other tissues.
DR ExpressionAtlas; Q94890; baseline and differential.
DR Genevisible; Q94890; DM.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0042684; P:cardioblast cell fate commitment; IMP:FlyBase.
DR GO; GO:0001708; P:cell fate specification; IBA:GO_Central.
DR GO; GO:0030381; P:chorion-containing eggshell pattern formation; IMP:FlyBase.
DR GO; GO:0035050; P:embryonic heart tube development; IMP:FlyBase.
DR GO; GO:0007507; P:heart development; IMP:FlyBase.
DR GO; GO:0003015; P:heart process; IDA:FlyBase.
DR GO; GO:0035223; P:leg disc pattern formation; IGI:FlyBase.
DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IDA:FlyBase.
DR GO; GO:0042659; P:regulation of cell fate specification; IGI:FlyBase.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR CDD; cd00182; TBOX; 1.
DR Gene3D; 2.60.40.820; -; 1.
DR InterPro; IPR008967; p53-like_TF_DNA-bd.
DR InterPro; IPR046360; T-box_DNA-bd.
DR InterPro; IPR036960; T-box_sf.
DR InterPro; IPR002070; TF_Brachyury.
DR InterPro; IPR001699; TF_T-box.
DR InterPro; IPR018186; TF_T-box_CS.
DR PANTHER; PTHR11267; PTHR11267; 1.
DR Pfam; PF00907; T-box; 1.
DR PRINTS; PR00938; BRACHYURY.
DR PRINTS; PR00937; TBOX.
DR SMART; SM00425; TBOX; 1.
DR SUPFAM; SSF49417; SSF49417; 1.
DR PROSITE; PS01283; TBOX_1; 1.
DR PROSITE; PS50252; TBOX_3; 1.
PE 2: Evidence at transcript level;
KW DNA-binding; Nucleus; Reference proteome; Transcription;
KW Transcription regulation.
FT CHAIN 1..660
FT /note="T-box protein H15"
FT /id="PRO_0000184468"
FT DNA_BIND 286..472
FT /note="T-box"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00201"
FT REGION 1..72
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 90..122
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 169..266
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 598..660
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..36
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 49..67
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 96..110
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 169..184
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 197..224
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 232..246
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 636..660
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 159
FT /note="Q -> P (in Ref. 1)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 660 AA; 72370 MW; 904BEF9AE684B58F CRC64;
MLLSNQPANT KPQQTPSPSQ TQNFKSKLQQ QIVSAAAAAA ANIANGSSHH HHHQNHHHHH
PLNNHHNHNH NQHNISFATD FSIAAIMARG GNAPSSREPS ERSLSPASVE RYSGQDADDD
VDVDVVDCSD SEMPSATAAA AAAATTAAAA AAALQAQQQA RQALRVAQQQ QQQQQQQRQQ
THHHATTGKQ QRQHHNHHSS NTNNSSNSGN SNTNSKSSSQ RGRSAAAVGA AATPSPPPPP
PSQSPEELER LSPEESPAQQ PTPKIVGSCN CDDLTPVQCH LETKELWDKF HELGTEMIIT
KSGRRMFPTV RVSFSGPLRQ IQPADRYAVL LDVVPLDSRR YRYAYHRSSW LVAGKADPPP
PSRIYAHPDC PLSPEALRKQ VVSFEKVKLT NNEMDKSGQV VLNSMHRYQP RIHLVRLSHG
QSIPGSPKEL QDMDHKTFVF PETVFTAVTA YQNQLITKLK IDSNPFAKGF RDSSRLSDFD
RDPMDAFFFD QHMRTAPLRF FPDPLMSQLT PQEADAASMA LLEKARQHLQ MFGRSPYTEM
LLPHLYQRSA APPPPPPAPH LSAFQLGMWQ QQWPQLTAGF LASANQQAAL ALAAAGANRT
PPPSMAVAPP APATPTSSCG SASPDLRARP QLNHYPQRFS PYQVPQHQAS PPASNRAESP
