ID   H16_CAEEL               Reviewed;         190 AA.
AC   O16277;
DT   11-OCT-2004, integrated into UniProtKB/Swiss-Prot.
DT   23-JAN-2007, sequence version 3.
DT   03-AUG-2022, entry version 122.
DE   RecName: Full=Putative histone H1.6;
DE   AltName: Full=Histone H1-like protein 6;
GN   Name=hil-6; ORFNames=F59A7.4;
OS   Caenorhabditis elegans.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=6239;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Bristol N2;
RX   PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG   The C. elegans sequencing consortium;
RT   "Genome sequence of the nematode C. elegans: a platform for investigating
RT   biology.";
RL   Science 282:2012-2018(1998).
RN   [2]
RP   DISCUSSION.
RX   PubMed=11245572; DOI=10.1242/dev.128.7.1069;
RA   Jedrusik M.A., Schulze E.;
RT   "A single histone H1 isoform (H1.1) is essential for chromatin silencing
RT   and germline development in Caenorhabditis elegans.";
RL   Development 128:1069-1080(2001).
CC   -!- FUNCTION: Histones H1 are necessary for the condensation of nucleosome
CC       chains into higher-order structures. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00837}.
CC       Chromosome {ECO:0000255|PROSITE-ProRule:PRU00837}.
CC   -!- SIMILARITY: Belongs to the histone H1/H5 family. {ECO:0000255|PROSITE-
CC       ProRule:PRU00837}.
CC   -!- CAUTION: PubMed:11245572 has not been able to detect expression of this
CC       protein. {ECO:0000305}.
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DR   EMBL; BX284605; CCD72097.1; -; Genomic_DNA.
DR   PIR; A88961; A88961.
DR   RefSeq; NP_503554.1; NM_071153.1.
DR   AlphaFoldDB; O16277; -.
DR   SMR; O16277; -.
DR   BioGRID; 51320; 1.
DR   STRING; 6239.F59A7.4; -.
DR   EPD; O16277; -.
DR   PaxDb; O16277; -.
DR   PeptideAtlas; O16277; -.
DR   EnsemblMetazoa; F59A7.4.1; F59A7.4.1; WBGene00001857.
DR   GeneID; 186584; -.
DR   KEGG; cel:CELE_F59A7.4; -.
DR   UCSC; F59A7.4; c. elegans.
DR   CTD; 186584; -.
DR   WormBase; F59A7.4; CE11442; WBGene00001857; hil-6.
DR   eggNOG; KOG4012; Eukaryota.
DR   GeneTree; ENSGT00970000195980; -.
DR   HOGENOM; CLU_052897_1_1_1; -.
DR   InParanoid; O16277; -.
DR   OMA; LMTIRVL; -.
DR   OrthoDB; 1565299at2759; -.
DR   PRO; PR:O16277; -.
DR   Proteomes; UP000001940; Chromosome V.
DR   Bgee; WBGene00001857; Expressed in germ line (C elegans) and 4 other tissues.
DR   GO; GO:0000786; C:nucleosome; IEA:InterPro.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0003690; F:double-stranded DNA binding; IBA:GO_Central.
DR   GO; GO:0031492; F:nucleosomal DNA binding; IBA:GO_Central.
DR   GO; GO:0030527; F:structural constituent of chromatin; IEA:InterPro.
DR   GO; GO:0030261; P:chromosome condensation; IBA:GO_Central.
DR   GO; GO:0045910; P:negative regulation of DNA recombination; IBA:GO_Central.
DR   GO; GO:0006334; P:nucleosome assembly; IEA:InterPro.
DR   CDD; cd00073; H15; 1.
DR   Gene3D; 1.10.10.10; -; 1.
DR   InterPro; IPR005819; H1/H5.
DR   InterPro; IPR005818; Histone_H1/H5_H15.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   Pfam; PF00538; Linker_histone; 1.
DR   PRINTS; PR00624; HISTONEH5.
DR   SMART; SM00526; H15; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   PROSITE; PS51504; H15; 1.
PE   3: Inferred from homology;
KW   Acetylation; Chromosome; DNA-binding; Nucleus; Reference proteome.
FT   INIT_MET        1
FT                   /note="Removed"
FT                   /evidence="ECO:0000250|UniProtKB:P10771"
FT   CHAIN           2..190
FT                   /note="Putative histone H1.6"
FT                   /id="PRO_0000195986"
FT   DOMAIN          34..110
FT                   /note="H15"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00837"
FT   REGION          1..29
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          141..190
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        142..170
FT                   /note="Basic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         2
FT                   /note="N-acetylserine"
FT                   /evidence="ECO:0000250|UniProtKB:P10771"
SQ   SEQUENCE   190 AA;  19747 MW;  91A58F0A00C54525 CRC64;
     MSDVAVAETP AVKTPTKAPK ANATKVPKVK TAAAHPPFIN MVTAAISSLK ERKGSSKIAI
     LKYITANYKL GDQVKKINSN LRSALKKGVA SKALVQTVGT GATGRFRVAE KTAATAKKPT
     VKKAATGEKV KKTVVKKTVA KKTGDKVKKA KSPKKIAKPA AKKATKSPSK KVAPKKAAAK
     PAKKTAALKA