ID   H18D1_CYRHA             Reviewed;         109 AA.
AC   D2Y2H2;
DT   02-NOV-2010, integrated into UniProtKB/Swiss-Prot.
DT   02-MAR-2010, sequence version 1.
DT   25-MAY-2022, entry version 20.
DE   RecName: Full=Hainantoxin-XVIII-4;
DE            Short=HNTX-XVIII-4;
DE   Flags: Precursor;
OS   Cyriopagopus hainanus (Chinese bird spider) (Haplopelma hainanum).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Chelicerata; Arachnida; Araneae;
OC   Mygalomorphae; Theraphosidae; Haplopelma.
OX   NCBI_TaxID=209901;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Venom gland;
RX   PubMed=20192277; DOI=10.1021/pr1000016;
RA   Tang X., Zhang Y., Hu W., Xu D., Tao H., Yang X., Li Y., Jiang L.,
RA   Liang S.;
RT   "Molecular diversification of peptide toxins from the tarantula Haplopelma
RT   hainanum (Ornithoctonus hainana) venom based on transcriptomic, peptidomic,
RT   and genomic analyses.";
RL   J. Proteome Res. 9:2550-2564(2010).
CC   -!- FUNCTION: Putative ion channel inhibitor.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC   -!- TISSUE SPECIFICITY: Expressed by the venom gland.
CC   -!- DOMAIN: The presence of a 'disulfide through disulfide knot'
CC       structurally defines this protein as a knottin. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the neurotoxin 25 family. F7 subfamily.
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DR   EMBL; GU293049; ADB56865.1; -; mRNA.
DR   AlphaFoldDB; D2Y2H2; -.
DR   ArachnoServer; AS001652; U14-theraphotoxin-Hhn1d.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0099106; F:ion channel regulator activity; IEA:UniProtKB-KW.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
PE   2: Evidence at transcript level;
KW   Disulfide bond; Ion channel impairing toxin; Knottin; Secreted; Signal;
KW   Toxin.
FT   SIGNAL          1..18
FT                   /evidence="ECO:0000255"
FT   PROPEP          19..46
FT                   /evidence="ECO:0000250"
FT                   /id="PRO_0000401043"
FT   PEPTIDE         47..109
FT                   /note="Hainantoxin-XVIII-4"
FT                   /id="PRO_0000401044"
FT   DISULFID        55..68
FT                   /evidence="ECO:0000250"
FT   DISULFID        59..108
FT                   /evidence="ECO:0000250"
FT   DISULFID        61..81
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   109 AA;  11879 MW;  A7AA4458B16670BA CRC64;
     MKLSIIIIAT SLVIAVVAFP SKDSKAIEND KTEQRMEIVV QETARACSKQ IGDKCKRNCE
     CYGKTVVCGT IYVGGKEVNQ CMDKTSDSAI LNGLGKGMNF IENTFSFCV