ID   H1C2_XENLA              Reviewed;         221 AA.
AC   P15867;
DT   01-APR-1990, integrated into UniProtKB/Swiss-Prot.
DT   23-JAN-2007, sequence version 2.
DT   03-AUG-2022, entry version 80.
DE   RecName: Full=Histone H1C;
DE   AltName: Full=Clone XLHW8;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=6866767; DOI=10.1093/nar/11.12.4093;
RA   Turner P.C., Aldridge T.C., Woodland H.R., Old R.W.;
RT   "Nucleotide sequences of H1 histone genes from Xenopus laevis. A recently
RT   diverged pair of H1 genes and an unusual H1 pseudogene.";
RL   Nucleic Acids Res. 11:4093-4107(1983).
CC   -!- FUNCTION: Histones H1 are necessary for the condensation of nucleosome
CC       chains into higher-order structures.
CC   -!- SUBCELLULAR LOCATION: Nucleus. Chromosome.
CC   -!- SIMILARITY: Belongs to the histone H1/H5 family. {ECO:0000255|PROSITE-
CC       ProRule:PRU00837}.
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DR   EMBL; J00969; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   AlphaFoldDB; P15867; -.
DR   SMR; P15867; -.
DR   PRIDE; P15867; -.
DR   Proteomes; UP000186698; Genome assembly.
DR   GO; GO:0000786; C:nucleosome; IEA:InterPro.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0030527; F:structural constituent of chromatin; IEA:InterPro.
DR   GO; GO:0006334; P:nucleosome assembly; IEA:InterPro.
DR   CDD; cd00073; H15; 1.
DR   Gene3D; 1.10.10.10; -; 1.
DR   InterPro; IPR005819; H1/H5.
DR   InterPro; IPR005818; Histone_H1/H5_H15.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   Pfam; PF00538; Linker_histone; 1.
DR   PRINTS; PR00624; HISTONEH5.
DR   SMART; SM00526; H15; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   PROSITE; PS51504; H15; 1.
PE   3: Inferred from homology;
KW   Chromosome; DNA-binding; Nucleus; Reference proteome.
FT   INIT_MET        1
FT                   /note="Removed"
FT                   /evidence="ECO:0000250"
FT   CHAIN           2..221
FT                   /note="Histone H1C"
FT                   /id="PRO_0000195936"
FT   DOMAIN          39..112
FT                   /note="H15"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00837"
FT   REGION          1..44
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          123..221
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        124..221
FT                   /note="Basic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   221 AA;  22748 MW;  CB25CE8B7A04F8C6 CRC64;
     MTETAATETT PAAPPAEPKQ KKKQQPKKAA GGAKAKKPSG PSASELIVKS VSASKERGGV
     SLAALKKALA AGGYNVERNN SRLKLALKAL VTKGTLTQVK GSGASGSFKL NKKQLETKVK
     AVAKKKLVAP KAKKPVAAKK KPKSPKKPKK VSAAAAKSPK KAKKPVKAAK SPKKPKAVKP
     KKVTKSPAKK ATKPKAAKAK IAKPKIAKAK AAKGKKAAAK K