H1D_STRPU
ID H1D_STRPU Reviewed; 185 AA.
AC P15870;
DT 01-APR-1990, integrated into UniProtKB/Swiss-Prot.
DT 01-APR-1990, sequence version 1.
DT 03-AUG-2022, entry version 102.
DE RecName: Full=Histone H1-delta;
OS Strongylocentrotus purpuratus (Purple sea urchin).
OC Eukaryota; Metazoa; Echinodermata; Eleutherozoa; Echinozoa; Echinoidea;
OC Euechinoidea; Echinacea; Camarodonta; Echinidea; Strongylocentrotidae;
OC Strongylocentrotus.
OX NCBI_TaxID=7668;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=2898141; DOI=10.1073/pnas.85.12.4123;
RA Lieber T., Angerer L.M., Angerer R.C., Childs G.;
RT "A histone H1 protein in sea urchins is encoded by a poly(A)+ mRNA.";
RL Proc. Natl. Acad. Sci. U.S.A. 85:4123-4127(1988).
CC -!- FUNCTION: Histones H1 are necessary for the condensation of nucleosome
CC chains into higher-order structures.
CC -!- SUBCELLULAR LOCATION: Nucleus. Chromosome.
CC -!- SIMILARITY: Belongs to the histone H1/H5 family. {ECO:0000255|PROSITE-
CC ProRule:PRU00837}.
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DR EMBL; J03807; AAA30055.1; -; Genomic_DNA.
DR PIR; A32137; A32137.
DR RefSeq; NP_999722.1; NM_214557.2.
DR AlphaFoldDB; P15870; -.
DR SMR; P15870; -.
DR STRING; 7668.SPU_028135-tr; -.
DR EnsemblMetazoa; NM_214557; NP_999722; LOC373353.
DR GeneID; 373353; -.
DR KEGG; spu:373353; -.
DR eggNOG; KOG4012; Eukaryota.
DR HOGENOM; CLU_052897_1_1_1; -.
DR InParanoid; P15870; -.
DR OMA; PTYSDMI; -.
DR OrthoDB; 1565299at2759; -.
DR PhylomeDB; P15870; -.
DR Proteomes; UP000007110; Unassembled WGS sequence.
DR GO; GO:0000786; C:nucleosome; IEA:InterPro.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0003690; F:double-stranded DNA binding; IBA:GO_Central.
DR GO; GO:0031492; F:nucleosomal DNA binding; IBA:GO_Central.
DR GO; GO:0030527; F:structural constituent of chromatin; IEA:InterPro.
DR GO; GO:0030261; P:chromosome condensation; IBA:GO_Central.
DR GO; GO:0045910; P:negative regulation of DNA recombination; IBA:GO_Central.
DR GO; GO:0006334; P:nucleosome assembly; IEA:InterPro.
DR CDD; cd00073; H15; 1.
DR Gene3D; 1.10.10.10; -; 1.
DR InterPro; IPR005819; H1/H5.
DR InterPro; IPR005818; Histone_H1/H5_H15.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR Pfam; PF00538; Linker_histone; 1.
DR PRINTS; PR00624; HISTONEH5.
DR SMART; SM00526; H15; 1.
DR SUPFAM; SSF46785; SSF46785; 1.
DR PROSITE; PS51504; H15; 1.
PE 3: Inferred from homology;
KW Chromosome; DNA-binding; Nucleus; Reference proteome.
FT CHAIN 1..185
FT /note="Histone H1-delta"
FT /id="PRO_0000195945"
FT DOMAIN 32..105
FT /note="H15"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00837"
FT REGION 1..37
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 90..185
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 113..185
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 185 AA; 19297 MW; DA6F3110F8F946E6 CRC64;
MADTDAAPAA PAPSTPKKAA KKKASKPKTP ASHPKYSDMI ASALESLKEK KGSSRQAILK
YVKANFTVGD NANVHIKQAL KRGVTSGQLR HVKGSGASGS FLLAEKTKTP KKAAAKKATP
KKKPAAKKTK KPAAKKATKK PAKKPAAKKK VAKPAAKKAA KPVAKKATPK KKVVKKAAKG
KGKKK