ID   H1E_STRPU               Reviewed;         205 AA.
AC   P19375;
DT   01-NOV-1990, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1990, sequence version 1.
DT   03-AUG-2022, entry version 96.
DE   RecName: Full=Histone H1, early embryonic;
OS   Strongylocentrotus purpuratus (Purple sea urchin).
OC   Eukaryota; Metazoa; Echinodermata; Eleutherozoa; Echinozoa; Echinoidea;
OC   Euechinoidea; Echinacea; Camarodonta; Echinidea; Strongylocentrotidae;
OC   Strongylocentrotus.
OX   NCBI_TaxID=7668;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=7107576; DOI=10.1016/s0021-9258(18)34089-4;
RA   Levy S., Sures I., Kedes L.;
RT   "The nucleotide and amino acid coding sequence of a gene for H1 histone
RT   that interacts with euchromatin. The early embryonic H1 gene of the sea
RT   urchin Strongylocentrotus purpuratus.";
RL   J. Biol. Chem. 257:9438-9443(1982).
CC   -!- FUNCTION: Histones H1 are necessary for the condensation of nucleosome
CC       chains into higher-order structures.
CC   -!- SUBCELLULAR LOCATION: Nucleus. Chromosome.
CC   -!- DEVELOPMENTAL STAGE: Early embryonic.
CC   -!- SIMILARITY: Belongs to the histone H1/H5 family. {ECO:0000255|PROSITE-
CC       ProRule:PRU00837}.
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DR   EMBL; V01354; CAA24644.1; -; Genomic_DNA.
DR   RefSeq; NP_999714.1; NM_214549.1.
DR   STRING; 7668.SPU_002822-tr; -.
DR   EnsemblMetazoa; NM_214549; NP_999714; LOC373342.
DR   GeneID; 373342; -.
DR   KEGG; spu:373342; -.
DR   eggNOG; KOG4012; Eukaryota.
DR   HOGENOM; CLU_052897_1_2_1; -.
DR   OMA; HPSTAKM; -.
DR   OrthoDB; 1565299at2759; -.
DR   PhylomeDB; P19375; -.
DR   Proteomes; UP000007110; Unassembled WGS sequence.
DR   GO; GO:0000786; C:nucleosome; IEA:InterPro.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0003690; F:double-stranded DNA binding; IBA:GO_Central.
DR   GO; GO:0031492; F:nucleosomal DNA binding; IBA:GO_Central.
DR   GO; GO:0030527; F:structural constituent of chromatin; IEA:InterPro.
DR   GO; GO:0030261; P:chromosome condensation; IBA:GO_Central.
DR   GO; GO:0045910; P:negative regulation of DNA recombination; IBA:GO_Central.
DR   GO; GO:0006334; P:nucleosome assembly; IEA:InterPro.
DR   CDD; cd00073; H15; 1.
DR   Gene3D; 1.10.10.10; -; 1.
DR   InterPro; IPR005819; H1/H5.
DR   InterPro; IPR005818; Histone_H1/H5_H15.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   Pfam; PF00538; Linker_histone; 1.
DR   PRINTS; PR00624; HISTONEH5.
DR   SMART; SM00526; H15; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   PROSITE; PS51504; H15; 1.
PE   2: Evidence at transcript level;
KW   Chromosome; DNA-binding; Nucleus; Reference proteome.
FT   CHAIN           1..205
FT                   /note="Histone H1, early embryonic"
FT                   /id="PRO_0000195946"
FT   DOMAIN          17..91
FT                   /note="H15"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00837"
FT   REGION          1..21
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          94..205
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        98..138
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        139..205
FT                   /note="Basic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   205 AA;  22175 MW;  FF553FA7B9C33853 CRC64;
     MAEKNSSKKV TTKKPAAHPP AAEMVATAIT ELKDRNGSSL QAIKKYIATN FDVQMDRQLL
     FIKRALKSGV EKGKLVQTKG KGASGSFKVN VQAAKAQASE KAKKEKEKAK LLAQREKAKE
     KGCSEEGETA EGSRPKKVKA APKKAKKPVK KTTEKKEKKK TPKKAPKKPA AKKSTPKKTP
     KKAAAKKPKT AKPKKPAXKK AAKSK