H1L_MYTCA
ID H1L_MYTCA Reviewed; 148 AA.
AC P22974;
DT 01-AUG-1991, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-1994, sequence version 2.
DT 03-AUG-2022, entry version 80.
DE RecName: Full=Sperm-specific protein PHI-2B;
DE AltName: Full=PL-II*;
DE AltName: Full=Sperm-specific linker histone H1-like protein;
OS Mytilus californianus (California mussel).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Bivalvia;
OC Autobranchia; Pteriomorphia; Mytilida; Mytiloidea; Mytilidae; Mytilinae;
OC Mytilus.
OX NCBI_TaxID=6549;
RN [1]
RP PROTEIN SEQUENCE.
RC TISSUE=Sperm;
RX PubMed=7677995; DOI=10.1016/s0021-9258(18)54132-6;
RA Carlos S., Jutglar L., Borrell I., Hunt D.F., Ausio J.;
RT "Sequence and characterization of a sperm-specific histone H1-like protein
RT of Mytilus californianus.";
RL J. Biol. Chem. 268:185-194(1993).
RN [2]
RP PROTEIN SEQUENCE OF 35-118.
RC TISSUE=Sperm;
RX PubMed=2022636; DOI=10.1016/s0021-9258(18)92959-5;
RA Jutglar L., Borrell J.I., Ausio J.;
RT "Primary, secondary, and tertiary structure of the core of a histone H1-
RT like protein from the sperm of Mytilus.";
RL J. Biol. Chem. 266:8184-8191(1991).
CC -!- FUNCTION: Linker histones are implicated in chromatin remodeling and/or
CC transcriptional regulation during spermiogenesis, the process of
CC spermatid maturation into spermatozoa. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus. Chromosome.
CC -!- TISSUE SPECIFICITY: Sperm.
CC -!- SIMILARITY: Belongs to the histone H1/H5 family. {ECO:0000255|PROSITE-
CC ProRule:PRU00837}.
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DR PIR; A45316; A45316.
DR AlphaFoldDB; P22974; -.
DR SMR; P22974; -.
DR GO; GO:0000786; C:nucleosome; IEA:UniProtKB-KW.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0030527; F:structural constituent of chromatin; IEA:InterPro.
DR GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
DR GO; GO:0030261; P:chromosome condensation; IEA:UniProtKB-KW.
DR GO; GO:0006334; P:nucleosome assembly; IEA:InterPro.
DR GO; GO:0007283; P:spermatogenesis; IEA:UniProtKB-KW.
DR CDD; cd00073; H15; 1.
DR Gene3D; 1.10.10.10; -; 1.
DR InterPro; IPR005819; H1/H5.
DR InterPro; IPR005818; Histone_H1/H5_H15.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR Pfam; PF00538; Linker_histone; 1.
DR PRINTS; PR00624; HISTONEH5.
DR SMART; SM00526; H15; 1.
DR SUPFAM; SSF46785; SSF46785; 1.
DR PROSITE; PS51504; H15; 1.
PE 1: Evidence at protein level;
KW Chromosome; Developmental protein; Differentiation;
KW Direct protein sequencing; DNA condensation; DNA-binding; Nucleosome core;
KW Nucleus; Spermatogenesis.
FT CHAIN 1..148
FT /note="Sperm-specific protein PHI-2B"
FT /id="PRO_0000196010"
FT DOMAIN 40..119
FT /note="H15"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00837"
FT REGION 1..44
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 97..148
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..38
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 122..142
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 148 AA; 15688 MW; 58ACFCE0B03114D3 CRC64;
PSPSRRSRSR SRSRSKSPKR SPAKKARKTP KKRRATGGAK KPSTLSMIVA AIQAMKNRKG
SSVQAIRKYI LANNKGINTS RLGSAMKLAF AKGLKSGVLV RPKTSAGASG ATGSFRVGKA
PSSPKKKAKK AKSPKKKSSK KSSNKSNN
