ID   H1L_SPISO               Reviewed;          75 AA.
AC   P22975;
DT   01-AUG-1991, integrated into UniProtKB/Swiss-Prot.
DT   01-AUG-1991, sequence version 1.
DT   25-MAY-2022, entry version 74.
DE   RecName: Full=Sperm-specific protein PL-I;
DE            Short=PL-I;
DE   AltName: Full=Sperm-specific linker histone H1-like protein;
DE   Flags: Fragment;
OS   Spisula solidissima (Atlantic surf-clam).
OC   Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Bivalvia;
OC   Autobranchia; Heteroconchia; Euheterodonta; Imparidentia; Neoheterodontei;
OC   Venerida; Mactroidea; Mactridae; Spisula.
OX   NCBI_TaxID=6584;
RN   [1]
RP   PROTEIN SEQUENCE.
RC   TISSUE=Sperm;
RX   PubMed=3567164; DOI=10.1021/bi00378a001;
RA   Ausio J., Toumadje A., McParland R., Becker R.R., Johnson W.C. Jr.,
RA   van Holde K.E.;
RT   "Structural characterization of the trypsin-resistant core in the nuclear
RT   sperm-specific protein from Spisula solidissima.";
RL   Biochemistry 26:975-982(1987).
CC   -!- FUNCTION: Linker histones are implicated in chromatin remodeling and/or
CC       transcriptional regulation during spermiogenesis, the process of
CC       spermatid maturation into spermatozoa. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus. Chromosome.
CC   -!- TISSUE SPECIFICITY: Sperm.
CC   -!- SIMILARITY: Belongs to the histone H1/H5 family. {ECO:0000255|PROSITE-
CC       ProRule:PRU00837}.
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DR   PIR; A27540; A27540.
DR   AlphaFoldDB; P22975; -.
DR   SMR; P22975; -.
DR   GO; GO:0000786; C:nucleosome; IEA:UniProtKB-KW.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
DR   GO; GO:0030261; P:chromosome condensation; IEA:UniProtKB-KW.
DR   GO; GO:0006334; P:nucleosome assembly; IEA:InterPro.
DR   GO; GO:0007283; P:spermatogenesis; IEA:UniProtKB-KW.
DR   CDD; cd00073; H15; 1.
DR   Gene3D; 1.10.10.10; -; 1.
DR   InterPro; IPR005818; Histone_H1/H5_H15.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   Pfam; PF00538; Linker_histone; 1.
DR   SMART; SM00526; H15; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   PROSITE; PS51504; H15; 1.
PE   1: Evidence at protein level;
KW   Chromosome; Developmental protein; Differentiation;
KW   Direct protein sequencing; DNA condensation; DNA-binding; Nucleosome core;
KW   Nucleus; Spermatogenesis.
FT   CHAIN           <1..>75
FT                   /note="Sperm-specific protein PL-I"
FT                   /id="PRO_0000196011"
FT   DOMAIN          2..74
FT                   /note="H15"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00837"
FT   NON_TER         1
FT   NON_TER         75
SQ   SEQUENCE   75 AA;  7644 MW;  B17A99515DA93BB7 CRC64;
     KGSSGMMSMV AAAIAANRTK KGASAQAIRK YVAAHSSLKG AVLNFRLRRA LAAGLKSGAL
     AHPKGSAGWV LVPKK