H1S_SPHGR
ID H1S_SPHGR Reviewed; 91 AA.
AC Q99284;
DT 23-JAN-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-FEB-1997, sequence version 1.
DT 03-AUG-2022, entry version 69.
DE RecName: Full=Histone H1, sperm;
DE Flags: Fragments;
OS Sphaerechinus granularis (Purple sea urchin).
OC Eukaryota; Metazoa; Echinodermata; Eleutherozoa; Echinozoa; Echinoidea;
OC Euechinoidea; Echinacea; Temnopleuroida; Toxopneustidae; Sphaerechinus.
OX NCBI_TaxID=39374;
RN [1] {ECO:0000305}
RP PROTEIN SEQUENCE.
RC TISSUE=Sperm {ECO:0000269|PubMed:7074115};
RX PubMed=7074115; DOI=10.1016/0167-4838(82)90015-2;
RA Strickland W.N., Strickland M., von Holt C., Giancotti V.;
RT "A partial structure of histone h1 from sperm of the sea urchin
RT Sphaerechinus granulosus.";
RL Biochim. Biophys. Acta 703:95-100(1982).
CC -!- FUNCTION: Histones H1 are necessary for the condensation of nucleosome
CC chains into higher-order structures.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}. Chromosome.
CC -!- SIMILARITY: Belongs to the histone H1/H5 family. {ECO:0000255|PROSITE-
CC ProRule:PRU00837}.
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DR AlphaFoldDB; Q99284; -.
DR SMR; Q99284; -.
DR GO; GO:0000786; C:nucleosome; IEA:InterPro.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0030527; F:structural constituent of chromatin; IEA:InterPro.
DR GO; GO:0006334; P:nucleosome assembly; IEA:InterPro.
DR CDD; cd00073; H15; 1.
DR Gene3D; 1.10.10.10; -; 1.
DR InterPro; IPR005819; H1/H5.
DR InterPro; IPR005818; Histone_H1/H5_H15.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR Pfam; PF00538; Linker_histone; 1.
DR PRINTS; PR00624; HISTONEH5.
DR SMART; SM00526; H15; 1.
DR SUPFAM; SSF46785; SSF46785; 1.
DR PROSITE; PS51504; H15; 1.
PE 1: Evidence at protein level;
KW Chromosome; Direct protein sequencing; DNA-binding; Nucleus.
FT CHAIN 1..>91
FT /note="Histone H1, sperm"
FT /id="PRO_0000273527"
FT DOMAIN 18..91
FT /note="H15"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00837"
FT REGION 1..25
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_CONS 25..26
FT /evidence="ECO:0000303|PubMed:7074115"
FT NON_TER 91
FT /evidence="ECO:0000303|PubMed:7074115"
SQ SEQUENCE 91 AA; 9729 MW; 54E1F6E542BB134B CRC64;
PGSPQKRAAS PRKSPRKGSP KKSPMIRAAI TAMRERKGSS VAKIKSYIAA NYRVNMTNLQ
PHIRRALRSG VASGALKQVT GTGATGRFRV G