H1_CHITH
ID H1_CHITH Reviewed; 231 AA.
AC P21895;
DT 01-MAY-1991, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-1991, sequence version 1.
DT 03-AUG-2022, entry version 78.
DE RecName: Full=Histone H1;
OS Chironomus thummi thummi (Midge).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Nematocera; Chironomoidea; Chironomidae;
OC Chironominae; Chironomus.
OX NCBI_TaxID=7155;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=2172549; DOI=10.1016/s0022-2836(05)80159-7;
RA Hankeln T., Schmidt E.R.;
RT "New foldback transposable element TFB1 found in histone genes of the midge
RT Chironomus thummi.";
RL J. Mol. Biol. 215:477-482(1990).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=1769271; DOI=10.1007/bf00360683;
RA Hankeln T., Schmidt E.R.;
RT "The organization, localization and nucleotide sequence of the histone
RT genes of the midge Chironomus thummi.";
RL Chromosoma 101:25-31(1991).
CC -!- FUNCTION: Histones H1 are necessary for the condensation of nucleosome
CC chains into higher-order structures.
CC -!- SUBCELLULAR LOCATION: Nucleus. Chromosome.
CC -!- SIMILARITY: Belongs to the histone H1/H5 family. {ECO:0000255|PROSITE-
CC ProRule:PRU00837}.
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DR EMBL; X56335; CAA39775.1; -; Genomic_DNA.
DR PIR; S18006; S18006.
DR AlphaFoldDB; P21895; -.
DR SMR; P21895; -.
DR GO; GO:0000786; C:nucleosome; IEA:InterPro.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0030527; F:structural constituent of chromatin; IEA:InterPro.
DR GO; GO:0006334; P:nucleosome assembly; IEA:InterPro.
DR CDD; cd00073; H15; 1.
DR Gene3D; 1.10.10.10; -; 1.
DR InterPro; IPR005819; H1/H5.
DR InterPro; IPR005818; Histone_H1/H5_H15.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR Pfam; PF00538; Linker_histone; 1.
DR PRINTS; PR00624; HISTONEH5.
DR SMART; SM00526; H15; 1.
DR SUPFAM; SSF46785; SSF46785; 1.
DR PROSITE; PS51504; H15; 1.
PE 3: Inferred from homology;
KW Chromosome; DNA-binding; Nucleus.
FT CHAIN 1..231
FT /note="Histone H1"
FT /id="PRO_0000195971"
FT DOMAIN 38..112
FT /note="H15"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00837"
FT REGION 1..44
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 124..231
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 125..170
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 231 AA; 24537 MW; E468F648A40AF51D CRC64;
MSDPAIEVAP VPVASPAKAK KEKKPKSDKP KKPKAPRTHP PVSDMIVNAI KTLKERGGSS
VQAIKKFLVA QYKVDTDKLS PFIKKYLKSA VEKGQLLQTK GKGASGSFKL PAAAKKEKVV
KKVTKKVTEK KPKKAVSKPK TGEKKVKKTI AKKPKVASAT KIKKPVAKTT KKPAAAKPTK
KVAAKPKAAP KPKAAPKPKV AKPKKAAAPK AKKPAAEKKP KAAKKPSAKK A