H1_DICDI
ID H1_DICDI Reviewed; 180 AA.
AC P54671; Q54NC4;
DT 01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT 23-JAN-2007, sequence version 3.
DT 03-AUG-2022, entry version 116.
DE RecName: Full=Histone H1;
GN Name=H1; Synonyms=hstA; ORFNames=DDB_G0285319;
OS Dictyostelium discoideum (Slime mold).
OC Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC Dictyosteliaceae; Dictyostelium.
OX NCBI_TaxID=44689;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND PROTEIN SEQUENCE OF 2-17.
RX PubMed=7867938; DOI=10.1016/0378-1119(94)00904-7;
RA Hauser L.J., Dhar M.S., Olins D.E.;
RT "Dictyostelium discoideum contains a single-copy gene encoding a unique
RT subtype of histone H1.";
RL Gene 154:119-122(1995).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=JH10;
RA O'Day D.H., Mackay L., Lydan M.A.;
RT "Multicellular dictyostelium histone H1 is a calmodulin-binding protein.";
RL Submitted (MAY-2002) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=15875012; DOI=10.1038/nature03481;
RA Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT "The genome of the social amoeba Dictyostelium discoideum.";
RL Nature 435:43-57(2005).
CC -!- FUNCTION: Histones H1 are necessary for the condensation of nucleosome
CC chains into higher-order structures.
CC -!- FUNCTION: Binds calmodulin.
CC -!- SUBCELLULAR LOCATION: Nucleus. Chromosome.
CC -!- PTM: Phosphorylated by H1 histone kinase (HKG).
CC -!- SIMILARITY: Belongs to the histone H1/H5 family. {ECO:0000255|PROSITE-
CC ProRule:PRU00837}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; L33457; AAA67370.1; -; Genomic_DNA.
DR EMBL; U50904; AAA93483.2; -; mRNA.
DR EMBL; AAFI02000079; EAL64734.1; -; Genomic_DNA.
DR RefSeq; XP_638256.1; XM_633164.1.
DR AlphaFoldDB; P54671; -.
DR SMR; P54671; -.
DR STRING; 44689.DDB0191459; -.
DR PaxDb; P54671; -.
DR EnsemblProtists; EAL64734; EAL64734; DDB_G0285319.
DR GeneID; 8625064; -.
DR KEGG; ddi:DDB_G0285319; -.
DR dictyBase; DDB_G0285319; H1.
DR eggNOG; ENOG502S79K; Eukaryota.
DR HOGENOM; CLU_052897_2_0_1; -.
DR InParanoid; P54671; -.
DR OMA; HPAYSDM; -.
DR PRO; PR:P54671; -.
DR Proteomes; UP000002195; Chromosome 4.
DR GO; GO:0031012; C:extracellular matrix; HDA:dictyBase.
DR GO; GO:0000786; C:nucleosome; IEA:InterPro.
DR GO; GO:0005634; C:nucleus; IDA:dictyBase.
DR GO; GO:0005516; F:calmodulin binding; TAS:dictyBase.
DR GO; GO:0003690; F:double-stranded DNA binding; IBA:GO_Central.
DR GO; GO:0031492; F:nucleosomal DNA binding; IBA:GO_Central.
DR GO; GO:0030527; F:structural constituent of chromatin; IEA:InterPro.
DR GO; GO:0030261; P:chromosome condensation; IBA:GO_Central.
DR GO; GO:0045910; P:negative regulation of DNA recombination; IBA:GO_Central.
DR GO; GO:0006334; P:nucleosome assembly; IEA:InterPro.
DR CDD; cd00073; H15; 1.
DR Gene3D; 1.10.10.10; -; 1.
DR InterPro; IPR005819; H1/H5.
DR InterPro; IPR005818; Histone_H1/H5_H15.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR Pfam; PF00538; Linker_histone; 1.
DR PRINTS; PR00624; HISTONEH5.
DR SMART; SM00526; H15; 1.
DR SUPFAM; SSF46785; SSF46785; 1.
DR PROSITE; PS51504; H15; 1.
PE 1: Evidence at protein level;
KW Calmodulin-binding; Chromosome; Direct protein sequencing; DNA-binding;
KW Nucleus; Phosphoprotein; Reference proteome.
FT INIT_MET 1
FT /note="Removed"
FT /evidence="ECO:0000269|PubMed:7867938"
FT CHAIN 2..180
FT /note="Histone H1"
FT /id="PRO_0000195988"
FT DOMAIN 23..92
FT /note="H15"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00837"
FT REGION 1..25
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 91..180
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 111..125
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 163..180
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 180 AA; 18860 MW; 08C41FBCF3B27E37 CRC64;
MGPKAPTTPT KKAAATKSKP KPNHPTYQVM ISTAIAHYKD RTGSSQPAII KYIEANYNVA
PDTFKTQLKL ALKRLVAKGT LTMVKASYKL SEEGKKEHQA TLGPVAKKPK AKTTATSTET
TAAPPATPTK KAAPKKPAAK AASTSTKTAA AKKNSAKVTK AVSKKPAAKK APSKKVAAKK
