ID   H1_DROHY                Reviewed;         249 AA.
AC   P17268;
DT   01-AUG-1990, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1995, sequence version 2.
DT   03-AUG-2022, entry version 88.
DE   RecName: Full=Histone H1;
GN   Name=His1;
OS   Drosophila hydei (Fruit fly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC   Drosophilidae; Drosophila.
OX   NCBI_TaxID=7224;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=2109309; DOI=10.1093/nar/18.6.1573;
RA   Kremer H., Hennig W.;
RT   "Isolation and characterization of a Drosophila hydei histone DNA repeat
RT   unit.";
RL   Nucleic Acids Res. 18:1573-1580(1990).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA   Strausbaugh L.D., Fitch D.H.A., Barrett V.;
RL   Submitted (APR-1990) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Histones H1 are necessary for the condensation of nucleosome
CC       chains into higher-order structures.
CC   -!- SUBCELLULAR LOCATION: Nucleus. Chromosome.
CC   -!- SIMILARITY: Belongs to the histone H1/H5 family. {ECO:0000255|PROSITE-
CC       ProRule:PRU00837}.
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DR   EMBL; X17072; CAA34918.1; -; Genomic_DNA.
DR   EMBL; X52576; CAA36804.1; -; Genomic_DNA.
DR   PIR; S21935; S21935.
DR   AlphaFoldDB; P17268; -.
DR   SMR; P17268; -.
DR   FlyBase; FBgn0012374; Dhyd\His1.
DR   OMA; HPRTSDM; -.
DR   GO; GO:0000786; C:nucleosome; IEA:InterPro.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0030527; F:structural constituent of chromatin; IEA:InterPro.
DR   GO; GO:0006334; P:nucleosome assembly; IEA:InterPro.
DR   CDD; cd00073; H15; 1.
DR   Gene3D; 1.10.10.10; -; 1.
DR   InterPro; IPR005819; H1/H5.
DR   InterPro; IPR005818; Histone_H1/H5_H15.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   Pfam; PF00538; Linker_histone; 1.
DR   PRINTS; PR00624; HISTONEH5.
DR   SMART; SM00526; H15; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   PROSITE; PS51504; H15; 1.
PE   3: Inferred from homology;
KW   Chromosome; DNA-binding; Nucleus.
FT   CHAIN           1..249
FT                   /note="Histone H1"
FT                   /id="PRO_0000195962"
FT   DOMAIN          45..119
FT                   /note="H15"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00837"
FT   REGION          1..53
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          105..249
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..18
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        34..53
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        121..135
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        155..193
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        235..249
FT                   /note="Basic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CONFLICT        208
FT                   /note="A -> P (in Ref. 2; CAA36804)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   249 AA;  25747 MW;  189236C05118F903 CRC64;
     MSDSVVAVSA SPVTPQTASA EKKVAAKKPA SASASKAKKT TAPPTHPPTQ QMVDASIQNL
     KERGGSSLLA IKKYISATYK CDAQKLAPFI KKYLKNSVAN GKLIQTKGKG ASGSFKLSAS
     SKKEPKPKVS SVEKKSKKVT SSAAAAKKKT ISATKKPKGV ADKKLSKAVV TKKSVDKKKA
     EKAKAKDAKK VGTIKAKPTT AKAKSSAAKP KTPKPKTTSA KPKKVVAAAS PKKAAAKKPK
     AKTASATKK