ID   H20A2_CYRHA             Reviewed;          78 AA.
AC   D2Y2H0;
DT   02-NOV-2010, integrated into UniProtKB/Swiss-Prot.
DT   02-MAR-2010, sequence version 1.
DT   25-MAY-2022, entry version 21.
DE   RecName: Full=Hainantoxin-XX.2;
DE            Short=HNTX-XX.2;
DE   AltName: Full=Peptide F8-26.11;
DE   Flags: Precursor;
OS   Cyriopagopus hainanus (Chinese bird spider) (Haplopelma hainanum).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Chelicerata; Arachnida; Araneae;
OC   Mygalomorphae; Theraphosidae; Haplopelma.
OX   NCBI_TaxID=209901;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Venom gland;
RX   PubMed=20192277; DOI=10.1021/pr1000016;
RA   Tang X., Zhang Y., Hu W., Xu D., Tao H., Yang X., Li Y., Jiang L.,
RA   Liang S.;
RT   "Molecular diversification of peptide toxins from the tarantula Haplopelma
RT   hainanum (Ornithoctonus hainana) venom based on transcriptomic, peptidomic,
RT   and genomic analyses.";
RL   J. Proteome Res. 9:2550-2564(2010).
RN   [2]
RP   FUNCTION, AND SYNTHESIS OF 48-78.
RX   PubMed=29483648; DOI=10.1038/s41594-018-0033-9;
RA   Correnti C.E., Gewe M.M., Mehlin C., Bandaranayake A.D., Johnsen W.A.,
RA   Rupert P.B., Brusniak M.Y., Clarke M., Burke S.E., De Van Der Schueren W.,
RA   Pilat K., Turnbaugh S.M., May D., Watson A., Chan M.K., Bahl C.D.,
RA   Olson J.M., Strong R.K.;
RT   "Screening, large-scale production and structure-based classification of
RT   cystine-dense peptides.";
RL   Nat. Struct. Mol. Biol. 25:270-278(2018).
CC   -!- FUNCTION: Moderately inhibits Kv1.1/KCNA1 and Kv1.2/KCNA2 and weakly
CC       inhibits Kv1.3/KCNA3, and Kv2.1/KCNB1 voltage-gated potassium channels
CC       (PubMed:29483648). {ECO:0000269|PubMed:29483648}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC   -!- TISSUE SPECIFICITY: Expressed by the venom gland.
CC   -!- DOMAIN: The presence of a 'disulfide through disulfide knot'
CC       structurally defines this protein as a knottin. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the hainantoxin family. 20 subfamily.
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DR   EMBL; GU293047; ADB56863.1; -; mRNA.
DR   AlphaFoldDB; D2Y2H0; -.
DR   SMR; D2Y2H0; -.
DR   ArachnoServer; AS001745; U13-theraphotoxin-Hhn1a.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0015459; F:potassium channel regulator activity; IEA:UniProtKB-KW.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
PE   2: Evidence at transcript level;
KW   Disulfide bond; Ion channel impairing toxin; Knottin;
KW   Potassium channel impairing toxin; Secreted; Signal; Toxin;
KW   Voltage-gated potassium channel impairing toxin.
FT   SIGNAL          1..23
FT                   /evidence="ECO:0000255"
FT   PROPEP          24..47
FT                   /evidence="ECO:0000250"
FT                   /id="PRO_0000401053"
FT   PEPTIDE         48..78
FT                   /note="Hainantoxin-XX.2"
FT                   /id="PRO_0000401054"
FT   DISULFID        49..62
FT                   /evidence="ECO:0000250"
FT   DISULFID        56..66
FT                   /evidence="ECO:0000250"
FT   DISULFID        61..77
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   78 AA;  8828 MW;  4483F54C8CA20A10 CRC64;
     MKSATLLALS YLLIALYFLI CEAEHSRYEE HEILEENMGD VVNLEQRSCA KPGEMCMRIK
     CCDGQCGCNR GTGRCFCK