H2A11_CYRHA
ID H2A11_CYRHA Reviewed; 84 AA.
AC D2Y229;
DT 02-NOV-2010, integrated into UniProtKB/Swiss-Prot.
DT 02-MAR-2010, sequence version 1.
DT 25-MAY-2022, entry version 24.
DE RecName: Full=U4-theraphotoxin-Hhn1a;
DE Short=U4-TRTX-Hhn1a;
DE AltName: Full=Hainantoxin-II.11;
DE Short=HNTX-II.11;
DE AltName: Full=Peptide F8-20.15;
DE Flags: Precursor;
OS Cyriopagopus hainanus (Chinese bird spider) (Haplopelma hainanum).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Chelicerata; Arachnida; Araneae;
OC Mygalomorphae; Theraphosidae; Haplopelma.
OX NCBI_TaxID=209901;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], PROTEIN SEQUENCE OF 49-85, AND
RP IDENTIFICATION BY MASS SPECTROMETRY.
RC TISSUE=Venom, and Venom gland;
RX PubMed=20192277; DOI=10.1021/pr1000016;
RA Tang X., Zhang Y., Hu W., Xu D., Tao H., Yang X., Li Y., Jiang L.,
RA Liang S.;
RT "Molecular diversification of peptide toxins from the tarantula Haplopelma
RT hainanum (Ornithoctonus hainana) venom based on transcriptomic, peptidomic,
RT and genomic analyses.";
RL J. Proteome Res. 9:2550-2564(2010).
CC -!- FUNCTION: Postsynaptic neurotoxin. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Secreted.
CC -!- TISSUE SPECIFICITY: Expressed by the venom gland.
CC -!- SIMILARITY: Belongs to the neurotoxin 12 (Hwtx-2) family. 02 (Hwtx-2)
CC subfamily. {ECO:0000305}.
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DR EMBL; GU292906; ADB56722.1; -; mRNA.
DR AlphaFoldDB; D2Y229; -.
DR SMR; D2Y229; -.
DR ArachnoServer; AS001783; U4-theraphotoxin-Hhn1a.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0035792; C:host cell postsynaptic membrane; IEA:UniProtKB-KW.
DR GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
DR InterPro; IPR012625; Toxin_20.
DR Pfam; PF08089; Toxin_20; 1.
DR PROSITE; PS60022; HWTX_2; 1.
PE 1: Evidence at protein level;
KW Direct protein sequencing; Disulfide bond; Neurotoxin;
KW Postsynaptic neurotoxin; Secreted; Signal; Toxin.
FT SIGNAL 1..22
FT /evidence="ECO:0000255"
FT PROPEP 23..47
FT /id="PRO_0000400737"
FT PEPTIDE 48..84
FT /note="U4-theraphotoxin-Hhn1a"
FT /id="PRO_0000400738"
FT DISULFID 51..65
FT /evidence="ECO:0000250"
FT DISULFID 55..76
FT /evidence="ECO:0000250"
FT DISULFID 70..81
FT /evidence="ECO:0000250"
SQ SEQUENCE 84 AA; 9255 MW; EEFB97FEC38662DC CRC64;
MKVTLIAILT CAAVLVLHTT AAEELEESQL MEVGMPDTEL AAVDGERLFE CSVSCEIEKE
GNKDCKKKKC KGGWKCKFNM CVKV