H2A1_LEIIN
ID H2A1_LEIIN Reviewed; 132 AA.
AC P27891; Q7K8Z7;
DT 01-AUG-1992, integrated into UniProtKB/Swiss-Prot.
DT 01-AUG-1992, sequence version 1.
DT 03-AUG-2022, entry version 91.
DE RecName: Full=Histone H2A.1;
OS Leishmania infantum.
OC Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC Trypanosomatida; Trypanosomatidae; Leishmaniinae; Leishmania.
OX NCBI_TaxID=5671;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=MHOM/FR/78/LEM 75;
RX PubMed=1555581; DOI=10.1111/j.1432-1033.1992.tb16770.x;
RA Soto M., Requena J.M., Gomez L.C., Navarrete I., Alonso C.;
RT "Molecular characterization of a Leishmania donovani infantum antigen
RT identified as histone H2A.";
RL Eur. J. Biochem. 205:211-216(1992).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=MHOM/FR/78/LEM 75;
RX PubMed=1679534; DOI=10.1093/nar/19.16.4554;
RA Soto M., Requena J.M., Jiminez-Ruiz A., Alonso C.;
RT "The mRNA coding for the nucleosomal protein H2A of Leishmania is
RT polyadenylated and has stem-loops at the 3' end.";
RL Nucleic Acids Res. 19:4554-4554(1991).
RN [3]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=MHOM/FR/78/LEM 75;
RX PubMed=12954010; DOI=10.1017/s0031182003003445;
RA Soto M., Quijada L., Larreta R., Iborra S., Alonso C., Requena J.M.;
RT "Leishmania infantum possesses a complex family of histone H2A genes: struc
RT tural characterization and analyisis of expression.";
RL Parasitology 127:95-105(2003).
CC -!- FUNCTION: Core component of nucleosome. Nucleosomes wrap and compact
CC DNA into chromatin, limiting DNA accessibility to the cellular
CC machineries which require DNA as a template. Histones thereby play a
CC central role in transcription regulation, DNA repair, DNA replication
CC and chromosomal stability. DNA accessibility is regulated via a complex
CC set of post-translational modifications of histones, also called
CC histone code, and nucleosome remodeling.
CC -!- SUBUNIT: The nucleosome is a histone octamer containing two molecules
CC each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and
CC two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of
CC DNA.
CC -!- SUBCELLULAR LOCATION: Nucleus. Chromosome.
CC -!- SIMILARITY: Belongs to the histone H2A family. {ECO:0000305}.
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DR EMBL; X60054; CAA42652.1; -; mRNA.
DR EMBL; AJ419627; CAD11895.1; -; Genomic_DNA.
DR PIR; S22303; S22303.
DR AlphaFoldDB; P27891; -.
DR SMR; P27891; -.
DR STRING; 5671.XP_003392461.1; -.
DR VEuPathDB; TriTrypDB:LINF_210016800; -.
DR eggNOG; KOG1756; Eukaryota.
DR GO; GO:0000786; C:nucleosome; IEA:UniProtKB-KW.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0046982; F:protein heterodimerization activity; IEA:InterPro.
DR GO; GO:0030527; F:structural constituent of chromatin; IEA:InterPro.
DR Gene3D; 1.10.20.10; -; 1.
DR InterPro; IPR009072; Histone-fold.
DR InterPro; IPR002119; Histone_H2A.
DR InterPro; IPR007125; Histone_H2A/H2B/H3.
DR InterPro; IPR032454; Histone_H2A_C.
DR InterPro; IPR032458; Histone_H2A_CS.
DR PANTHER; PTHR23430; PTHR23430; 1.
DR Pfam; PF00125; Histone; 1.
DR Pfam; PF16211; Histone_H2A_C; 1.
DR PRINTS; PR00620; HISTONEH2A.
DR SMART; SM00414; H2A; 1.
DR SUPFAM; SSF47113; SSF47113; 1.
DR PROSITE; PS00046; HISTONE_H2A; 1.
PE 2: Evidence at transcript level;
KW Chromosome; DNA-binding; Nucleosome core; Nucleus.
FT CHAIN 1..132
FT /note="Histone H2A.1"
FT /id="PRO_0000055246"
SQ SEQUENCE 132 AA; 13892 MW; B53F3EDA20970F43 CRC64;
MATPRSAKKA VRKSGSKSAK CGLIFPVGRV GGMMRRGQYA RRIGASGAVY LAAVLEYLTA
ELLELSVKAA AQSGKKRCRL NPRTVMLAAR HDDDIGTLLK NVTLSHSGVV PNISKAMAKK
KGGKKGKATP SA