ID   H2A1_MEDTR              Reviewed;         148 AA.
AC   Q2HU68;
DT   13-JUN-2006, integrated into UniProtKB/Swiss-Prot.
DT   21-MAR-2006, sequence version 1.
DT   03-AUG-2022, entry version 67.
DE   RecName: Full=Probable histone H2A.1;
GN   ORFNames=MtrDRAFT_AC149210g1v1;
OS   Medicago truncatula (Barrel medic) (Medicago tribuloides).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   rosids; fabids; Fabales; Fabaceae; Papilionoideae; 50 kb inversion clade;
OC   NPAAA clade; Hologalegina; IRL clade; Trifolieae; Medicago.
OX   NCBI_TaxID=3880;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG   The international Medicago genome annotation group;
RL   Submitted (APR-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Core component of nucleosome. Nucleosomes wrap and compact
CC       DNA into chromatin, limiting DNA accessibility to the cellular
CC       machineries which require DNA as a template. Histones thereby play a
CC       central role in transcription regulation, DNA repair, DNA replication
CC       and chromosomal stability. DNA accessibility is regulated via a complex
CC       set of post-translational modifications of histones, also called
CC       histone code, and nucleosome remodeling.
CC   -!- SUBUNIT: The nucleosome is a histone octamer containing two molecules
CC       each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and
CC       two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of
CC       DNA.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}. Chromosome {ECO:0000250}.
CC   -!- DOMAIN: Contains 2 SPKK motifs which may interact with the minor groove
CC       of A/T-rich DNA sites. Phosphorylation of this motif may regulate DNA
CC       binding. This motif is reiterated in both termini of histone H1 and in
CC       the N-terminus of sea urchin histones H2B, but its presence in the C-
CC       terminus seems to be unique to plant H2A.
CC   -!- SIMILARITY: Belongs to the histone H2A family. {ECO:0000305}.
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DR   EMBL; AC149210; ABD32277.1; -; Genomic_DNA.
DR   RefSeq; XP_003597346.1; XM_003597298.2.
DR   AlphaFoldDB; Q2HU68; -.
DR   SMR; Q2HU68; -.
DR   STRING; 3880.AES67597; -.
DR   ProMEX; Q2HU68; -.
DR   EnsemblPlants; AES67597; AES67597; MTR_2g096610.
DR   GeneID; 11418081; -.
DR   Gramene; AES67597; AES67597; MTR_2g096610.
DR   eggNOG; KOG1756; Eukaryota.
DR   HOGENOM; CLU_062828_1_1_1; -.
DR   OMA; KANSGRD; -.
DR   OrthoDB; 1504122at2759; -.
DR   ExpressionAtlas; Q2HU68; differential.
DR   GO; GO:0000786; C:nucleosome; IEA:UniProtKB-KW.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0046982; F:protein heterodimerization activity; IEA:InterPro.
DR   GO; GO:0030527; F:structural constituent of chromatin; IEA:InterPro.
DR   CDD; cd00074; H2A; 1.
DR   Gene3D; 1.10.20.10; -; 1.
DR   InterPro; IPR009072; Histone-fold.
DR   InterPro; IPR002119; Histone_H2A.
DR   InterPro; IPR007125; Histone_H2A/H2B/H3.
DR   InterPro; IPR032454; Histone_H2A_C.
DR   InterPro; IPR032458; Histone_H2A_CS.
DR   PANTHER; PTHR23430; PTHR23430; 1.
DR   Pfam; PF00125; Histone; 1.
DR   Pfam; PF16211; Histone_H2A_C; 1.
DR   PRINTS; PR00620; HISTONEH2A.
DR   SMART; SM00414; H2A; 1.
DR   SUPFAM; SSF47113; SSF47113; 1.
DR   PROSITE; PS00046; HISTONE_H2A; 1.
PE   3: Inferred from homology;
KW   Chromosome; DNA-binding; Nucleosome core; Nucleus.
FT   CHAIN           1..148
FT                   /note="Probable histone H2A.1"
FT                   /id="PRO_0000239992"
FT   REGION          1..28
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          127..148
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOTIF           137..140
FT                   /note="SPKK motif 1"
FT   MOTIF           144..147
FT                   /note="SPKK motif 2"
SQ   SEQUENCE   148 AA;  15746 MW;  EC875867818935A5 CRC64;
     MDASTKTKKG AGGRKGGPRK KSVTRSTRAG LQFPVGRIGR YLKKGRYAQR VGTGAPVYLA
     AVLEYLAAEV LELAGNAARD NKKNRIIPRH VLLAVRNDEE LGKLLAGVTI AHGGVLPNIN
     PILLPKKNEK AATTTKSPSK ATKSPKKA