H2A1_WHEAT
ID H2A1_WHEAT Reviewed; 146 AA.
AC P02275; Q43310; Q9SB25;
DT 21-JUL-1986, integrated into UniProtKB/Swiss-Prot.
DT 23-JAN-2007, sequence version 2.
DT 03-AUG-2022, entry version 118.
DE RecName: Full=Histone H2A.1;
DE AltName: Full=wcH2A-9;
GN Name=H2A-9; Synonyms=TH274;
OS Triticum aestivum (Wheat).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; Liliopsida; Poales; Poaceae; BOP clade;
OC Pooideae; Triticodae; Triticeae; Triticinae; Triticum.
OX NCBI_TaxID=4565;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=7893754; DOI=10.1016/0167-4781(95)00017-b;
RA Huh G.H., Matsuura Y., Meshi T., Iwabuchi M.;
RT "Differential expression of the two types of histone H2A genes in wheat.";
RL Biochim. Biophys. Acta 1261:155-160(1995).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], DEVELOPMENTAL STAGE, AND TISSUE
RP SPECIFICITY.
RX PubMed=9106503; DOI=10.1023/a:1005768104540;
RA Huh G.H., Nakayama T., Meshi T., Iwabuchi M.;
RT "Structural characteristics of two wheat histone H2A genes encoding
RT distinct types of variants and functional differences in their promoter
RT activity.";
RL Plant Mol. Biol. 33:791-802(1997).
RN [3]
RP PROTEIN SEQUENCE OF 2-146.
RC TISSUE=Germ;
RX PubMed=4018096; DOI=10.1111/j.1432-1033.1985.tb09050.x;
RA Rodrigues J.A., Brandt W.F., von Holt C.;
RT "The amino acid sequence of wheat histone H2A(1). A core histone with a C-
RT terminal extension.";
RL Eur. J. Biochem. 150:499-506(1985).
RN [4]
RP PROTEIN SEQUENCE OF 2-55.
RX PubMed=454665; DOI=10.1016/0005-2795(79)90127-2;
RA Rodrigues J.A., Brandt W.F., von Holt C.;
RT "Plant histone 2 from wheat germ, a family of histone H2a variants. Partial
RT amino acid sequences.";
RL Biochim. Biophys. Acta 578:196-206(1979).
RN [5]
RP PHOSPHORYLATION.
RX PubMed=16667585; DOI=10.1104/pp.93.3.1241;
RA Green G.R., Gustavsen L.C., Poccia D.L.;
RT "Phosphorylation of plant H2A histones.";
RL Plant Physiol. 93:1241-1245(1990).
CC -!- FUNCTION: Core component of nucleosome. Nucleosomes wrap and compact
CC DNA into chromatin, limiting DNA accessibility to the cellular
CC machineries which require DNA as a template. Histones thereby play a
CC central role in transcription regulation, DNA repair, DNA replication
CC and chromosomal stability. DNA accessibility is regulated via a complex
CC set of post-translational modifications of histones, also called
CC histone code, and nucleosome remodeling.
CC -!- SUBUNIT: The nucleosome is a histone octamer containing two molecules
CC each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and
CC two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of
CC DNA.
CC -!- SUBCELLULAR LOCATION: Nucleus. Chromosome.
CC -!- TISSUE SPECIFICITY: Expressed preferentially in meristematic tissues of
CC young seedlings, in stigma and ovary but not in pollen.
CC {ECO:0000269|PubMed:9106503}.
CC -!- DEVELOPMENTAL STAGE: S phase-specific expression.
CC {ECO:0000269|PubMed:9106503}.
CC -!- DOMAIN: Contains 2 SPKK motifs which may interact with the minor groove
CC of A/T-rich DNA sites. Phosphorylation of this motif may regulate DNA
CC binding. This motif is reiterated in both termini of histone H1 and in
CC the N-terminus of sea urchin histones H2B, but its presence in the C-
CC terminus seems to be unique to plant H2A.
CC -!- PTM: Phosphorylated within its C-terminal part, probably at the SPKK
CC motifs. {ECO:0000269|PubMed:16667585}.
CC -!- SIMILARITY: Belongs to the histone H2A family. {ECO:0000305}.
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DR EMBL; D38090; BAA07279.1; -; mRNA.
DR EMBL; X94973; CAA64423.1; -; Genomic_DNA.
DR EMBL; L75802; AAB00193.1; -; Genomic_DNA.
DR PIR; A02602; HSWT91.
DR PIR; S53519; S53519.
DR AlphaFoldDB; P02275; -.
DR SMR; P02275; -.
DR STRING; 4565.Traes_6AS_AFBB715C3.3; -.
DR PRIDE; P02275; -.
DR EnsemblPlants; TraesCAD_scaffold_000238_01G000100.1; TraesCAD_scaffold_000238_01G000100.1; TraesCAD_scaffold_000238_01G000100.
DR EnsemblPlants; TraesCAD_scaffold_000310_01G000600.1; TraesCAD_scaffold_000310_01G000600.1; TraesCAD_scaffold_000310_01G000600.
DR EnsemblPlants; TraesCAD_scaffold_062092_01G000200.1; TraesCAD_scaffold_062092_01G000200.1; TraesCAD_scaffold_062092_01G000200.
DR EnsemblPlants; TraesCAD_scaffold_109410_01G000200.1; TraesCAD_scaffold_109410_01G000200.1; TraesCAD_scaffold_109410_01G000200.
DR EnsemblPlants; TraesCAD_scaffold_144309_01G000100.1; TraesCAD_scaffold_144309_01G000100.1; TraesCAD_scaffold_144309_01G000100.
DR EnsemblPlants; TraesCLE_scaffold_016178_01G000200.1; TraesCLE_scaffold_016178_01G000200.1; TraesCLE_scaffold_016178_01G000200.
DR EnsemblPlants; TraesCLE_scaffold_017125_01G000300.1; TraesCLE_scaffold_017125_01G000300.1; TraesCLE_scaffold_017125_01G000300.
DR EnsemblPlants; TraesCLE_scaffold_088409_01G000100.1; TraesCLE_scaffold_088409_01G000100.1; TraesCLE_scaffold_088409_01G000100.
DR EnsemblPlants; TraesCLE_scaffold_090853_01G000200.1; TraesCLE_scaffold_090853_01G000200.1; TraesCLE_scaffold_090853_01G000200.
DR EnsemblPlants; TraesCS6B02G049200.1; TraesCS6B02G049200.1; TraesCS6B02G049200.
DR EnsemblPlants; TraesCS6B02G049400.1; TraesCS6B02G049400.1; TraesCS6B02G049400.
DR EnsemblPlants; TraesCS6D02G040700.1; TraesCS6D02G040700.1; TraesCS6D02G040700.
DR EnsemblPlants; TraesPAR_scaffold_004459_01G000400.1; TraesPAR_scaffold_004459_01G000400.1; TraesPAR_scaffold_004459_01G000400.
DR EnsemblPlants; TraesPAR_scaffold_020585_01G000300.1; TraesPAR_scaffold_020585_01G000300.1; TraesPAR_scaffold_020585_01G000300.
DR EnsemblPlants; TraesPAR_scaffold_064885_01G000200.1; TraesPAR_scaffold_064885_01G000200.1; TraesPAR_scaffold_064885_01G000200.
DR EnsemblPlants; TraesPAR_scaffold_130930_01G000200.1; TraesPAR_scaffold_130930_01G000200.1; TraesPAR_scaffold_130930_01G000200.
DR EnsemblPlants; TraesROB_scaffold_004261_01G000300.1; TraesROB_scaffold_004261_01G000300.1; TraesROB_scaffold_004261_01G000300.
DR EnsemblPlants; TraesROB_scaffold_031739_01G000300.1; TraesROB_scaffold_031739_01G000300.1; TraesROB_scaffold_031739_01G000300.
DR EnsemblPlants; TraesROB_scaffold_041730_01G000500.1; TraesROB_scaffold_041730_01G000500.1; TraesROB_scaffold_041730_01G000500.
DR EnsemblPlants; TraesROB_scaffold_064611_01G000200.1; TraesROB_scaffold_064611_01G000200.1; TraesROB_scaffold_064611_01G000200.
DR EnsemblPlants; TraesWEE_scaffold_008448_01G000500.1; TraesWEE_scaffold_008448_01G000500.1; TraesWEE_scaffold_008448_01G000500.
DR EnsemblPlants; TraesWEE_scaffold_021255_01G000300.1; TraesWEE_scaffold_021255_01G000300.1; TraesWEE_scaffold_021255_01G000300.
DR EnsemblPlants; TraesWEE_scaffold_059022_01G000200.1; TraesWEE_scaffold_059022_01G000200.1; TraesWEE_scaffold_059022_01G000200.
DR EnsemblPlants; TraesWEE_scaffold_149981_01G000200.1; TraesWEE_scaffold_149981_01G000200.1; TraesWEE_scaffold_149981_01G000200.
DR Gramene; TraesCAD_scaffold_000238_01G000100.1; TraesCAD_scaffold_000238_01G000100.1; TraesCAD_scaffold_000238_01G000100.
DR Gramene; TraesCAD_scaffold_000310_01G000600.1; TraesCAD_scaffold_000310_01G000600.1; TraesCAD_scaffold_000310_01G000600.
DR Gramene; TraesCAD_scaffold_062092_01G000200.1; TraesCAD_scaffold_062092_01G000200.1; TraesCAD_scaffold_062092_01G000200.
DR Gramene; TraesCAD_scaffold_109410_01G000200.1; TraesCAD_scaffold_109410_01G000200.1; TraesCAD_scaffold_109410_01G000200.
DR Gramene; TraesCAD_scaffold_144309_01G000100.1; TraesCAD_scaffold_144309_01G000100.1; TraesCAD_scaffold_144309_01G000100.
DR Gramene; TraesCLE_scaffold_016178_01G000200.1; TraesCLE_scaffold_016178_01G000200.1; TraesCLE_scaffold_016178_01G000200.
DR Gramene; TraesCLE_scaffold_017125_01G000300.1; TraesCLE_scaffold_017125_01G000300.1; TraesCLE_scaffold_017125_01G000300.
DR Gramene; TraesCLE_scaffold_088409_01G000100.1; TraesCLE_scaffold_088409_01G000100.1; TraesCLE_scaffold_088409_01G000100.
DR Gramene; TraesCLE_scaffold_090853_01G000200.1; TraesCLE_scaffold_090853_01G000200.1; TraesCLE_scaffold_090853_01G000200.
DR Gramene; TraesCS6B02G049200.1; TraesCS6B02G049200.1; TraesCS6B02G049200.
DR Gramene; TraesCS6B02G049400.1; TraesCS6B02G049400.1; TraesCS6B02G049400.
DR Gramene; TraesCS6D02G040700.1; TraesCS6D02G040700.1; TraesCS6D02G040700.
DR Gramene; TraesPAR_scaffold_004459_01G000400.1; TraesPAR_scaffold_004459_01G000400.1; TraesPAR_scaffold_004459_01G000400.
DR Gramene; TraesPAR_scaffold_020585_01G000300.1; TraesPAR_scaffold_020585_01G000300.1; TraesPAR_scaffold_020585_01G000300.
DR Gramene; TraesPAR_scaffold_064885_01G000200.1; TraesPAR_scaffold_064885_01G000200.1; TraesPAR_scaffold_064885_01G000200.
DR Gramene; TraesPAR_scaffold_130930_01G000200.1; TraesPAR_scaffold_130930_01G000200.1; TraesPAR_scaffold_130930_01G000200.
DR Gramene; TraesROB_scaffold_004261_01G000300.1; TraesROB_scaffold_004261_01G000300.1; TraesROB_scaffold_004261_01G000300.
DR Gramene; TraesROB_scaffold_031739_01G000300.1; TraesROB_scaffold_031739_01G000300.1; TraesROB_scaffold_031739_01G000300.
DR Gramene; TraesROB_scaffold_041730_01G000500.1; TraesROB_scaffold_041730_01G000500.1; TraesROB_scaffold_041730_01G000500.
DR Gramene; TraesROB_scaffold_064611_01G000200.1; TraesROB_scaffold_064611_01G000200.1; TraesROB_scaffold_064611_01G000200.
DR Gramene; TraesWEE_scaffold_008448_01G000500.1; TraesWEE_scaffold_008448_01G000500.1; TraesWEE_scaffold_008448_01G000500.
DR Gramene; TraesWEE_scaffold_021255_01G000300.1; TraesWEE_scaffold_021255_01G000300.1; TraesWEE_scaffold_021255_01G000300.
DR Gramene; TraesWEE_scaffold_059022_01G000200.1; TraesWEE_scaffold_059022_01G000200.1; TraesWEE_scaffold_059022_01G000200.
DR Gramene; TraesWEE_scaffold_149981_01G000200.1; TraesWEE_scaffold_149981_01G000200.1; TraesWEE_scaffold_149981_01G000200.
DR eggNOG; KOG1756; Eukaryota.
DR Proteomes; UP000019116; Unplaced.
DR GO; GO:0000786; C:nucleosome; IEA:UniProtKB-KW.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IBA:GO_Central.
DR GO; GO:0046982; F:protein heterodimerization activity; IEA:InterPro.
DR GO; GO:0030527; F:structural constituent of chromatin; IEA:InterPro.
DR CDD; cd00074; H2A; 1.
DR Gene3D; 1.10.20.10; -; 1.
DR InterPro; IPR009072; Histone-fold.
DR InterPro; IPR002119; Histone_H2A.
DR InterPro; IPR007125; Histone_H2A/H2B/H3.
DR InterPro; IPR032454; Histone_H2A_C.
DR InterPro; IPR032458; Histone_H2A_CS.
DR PANTHER; PTHR23430; PTHR23430; 1.
DR Pfam; PF00125; Histone; 1.
DR Pfam; PF16211; Histone_H2A_C; 1.
DR PRINTS; PR00620; HISTONEH2A.
DR SMART; SM00414; H2A; 1.
DR SUPFAM; SSF47113; SSF47113; 1.
DR PROSITE; PS00046; HISTONE_H2A; 1.
PE 1: Evidence at protein level;
KW Chromosome; Direct protein sequencing; DNA-binding; Nucleosome core;
KW Nucleus; Phosphoprotein; Reference proteome.
FT INIT_MET 1
FT /note="Removed"
FT /evidence="ECO:0000269|PubMed:4018096,
FT ECO:0000269|PubMed:454665"
FT CHAIN 2..146
FT /note="Histone H2A.1"
FT /id="PRO_0000055291"
FT REGION 118..146
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOTIF 128..131
FT /note="SPKK motif 1"
FT MOTIF 137..140
FT /note="SPKK motif 2"
FT CONFLICT 41
FT /note="V -> I (in Ref. 2; CAA64423/AAB00193)"
FT /evidence="ECO:0000305"
FT CONFLICT 108
FT /note="N -> T (in Ref. 2; CAA64423/AAB00193)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 146 AA; 15586 MW; 77ADCD9D8A43A90D CRC64;
MAGRKGGDRK KAVTRSVKAG LQFPVGRIGR YLKKGRYAQR VGSGAPVYLA AVLEYLAAEV
LELAGNAAKD NKKTRIIPRH LLLAVRNDQE LGRLLAGVTI AHGGVIPNIN SVLLPKKSPA
AAEKEAKSPK KKTSTKSPKK KVAAKE
