ID   AMYA_METJA              Reviewed;         467 AA.
AC   Q59006;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   25-MAY-2022, entry version 99.
DE   RecName: Full=Putative alpha-amylase;
DE            EC=3.2.1.1;
GN   OrderedLocusNames=MJ1611;
OS   Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM
OS   10045 / NBRC 100440) (Methanococcus jannaschii).
OC   Archaea; Euryarchaeota; Methanomada group; Methanococci; Methanococcales;
OC   Methanocaldococcaceae; Methanocaldococcus.
OX   NCBI_TaxID=243232;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440;
RX   PubMed=8688087; DOI=10.1126/science.273.5278.1058;
RA   Bult C.J., White O., Olsen G.J., Zhou L., Fleischmann R.D., Sutton G.G.,
RA   Blake J.A., FitzGerald L.M., Clayton R.A., Gocayne J.D., Kerlavage A.R.,
RA   Dougherty B.A., Tomb J.-F., Adams M.D., Reich C.I., Overbeek R.,
RA   Kirkness E.F., Weinstock K.G., Merrick J.M., Glodek A., Scott J.L.,
RA   Geoghagen N.S.M., Weidman J.F., Fuhrmann J.L., Nguyen D., Utterback T.R.,
RA   Kelley J.M., Peterson J.D., Sadow P.W., Hanna M.C., Cotton M.D.,
RA   Roberts K.M., Hurst M.A., Kaine B.P., Borodovsky M., Klenk H.-P.,
RA   Fraser C.M., Smith H.O., Woese C.R., Venter J.C.;
RT   "Complete genome sequence of the methanogenic archaeon, Methanococcus
RT   jannaschii.";
RL   Science 273:1058-1073(1996).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=Endohydrolysis of (1->4)-alpha-D-glucosidic linkages in
CC         polysaccharides containing three or more (1->4)-alpha-linked D-
CC         glucose units.; EC=3.2.1.1;
CC   -!- SIMILARITY: Belongs to the glycosyl hydrolase 57 family. {ECO:0000305}.
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DR   EMBL; L77117; AAB99631.1; -; Genomic_DNA.
DR   PIR; B64501; B64501.
DR   RefSeq; WP_010871136.1; NC_000909.1.
DR   AlphaFoldDB; Q59006; -.
DR   SMR; Q59006; -.
DR   STRING; 243232.MJ_1611; -.
DR   CAZy; GH57; Glycoside Hydrolase Family 57.
DR   EnsemblBacteria; AAB99631; AAB99631; MJ_1611.
DR   GeneID; 1452520; -.
DR   KEGG; mja:MJ_1611; -.
DR   eggNOG; arCOG03278; Archaea.
DR   HOGENOM; CLU_033691_0_0_2; -.
DR   InParanoid; Q59006; -.
DR   OMA; GWRSPNY; -.
DR   OrthoDB; 45403at2157; -.
DR   PhylomeDB; Q59006; -.
DR   Proteomes; UP000000805; Chromosome.
DR   GO; GO:0004556; F:alpha-amylase activity; IEA:UniProtKB-EC.
DR   GO; GO:0005975; P:carbohydrate metabolic process; IEA:UniProtKB-KW.
DR   InterPro; IPR011330; Glyco_hydro/deAcase_b/a-brl.
DR   InterPro; IPR004300; Glyco_hydro_57_N.
DR   Pfam; PF03065; Glyco_hydro_57; 1.
DR   SUPFAM; SSF88713; SSF88713; 1.
PE   3: Inferred from homology;
KW   Carbohydrate metabolism; Glycosidase; Hydrolase; Reference proteome.
FT   CHAIN           1..467
FT                   /note="Putative alpha-amylase"
FT                   /id="PRO_0000184575"
FT   ACT_SITE        145
FT                   /note="Nucleophile"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   467 AA;  55558 MW;  40A6B1CDDD4D967E CRC64;
     MLITFNFEVH QPHRLNKEIN QNGNTLWEKY VDTKLNKEVF NKVANKCYIP TNELILELID
     EYDFKVNYSI TGVFVEQALE FNDYVLDLFK DLVKTGNVEL IAETYHHSLT SLFETEDEFI
     EDIEMHRKMY KEIFGFKAKV FRNTELIYNN RIAKIAKDLG FKAIFTEGIE KILGWRSPNY
     LYQSPDGMKI LLRNYRLSDD IGFRFSARDW DQYPLTADKY AIWLASTPGE VINIYMDYET
     FGEHHWKETG IFEFLRYLPI EIAKHEHLEV VNVSEVVDRL EPRGEIYVHE FATISWADTE
     RDVSAWLGNK MQRISFEKLK DIGKFIKENS NKLKKLNKFD EIYKMYKVLQ TSDNLYYQSI
     KGLSDMSVHN YFSHFDTPFD AYASYLNILY DFEYYIKELL AKSEFDKNNR RKDGQKQYEK
     DDEVKKESLI NTNIIVAKDD KTESIYIEDE EGKKNKRYER DEGFIIA